Antioxidant and anti-inflammatory activity of constituents isolated from Dendrobium nobile (Lindl.)

Abstract

Dendrobium nobile (Lindl.) have long been used as herbal tea and a traditional herbal medicine to treat Alzheimer’s disease (AD). In the current study, nineteen compounds (1–19), including two new vitamin E homologues (1–2), one new sesquiterpene (6), and two new dendrobines (7, 8), were isolated and identified from stems of Dendrobium nobile. Their structures were elucidated on the basis of NMR, 13C NMR calculation, and DP4+ probability analyses. The absolute configurations of new compounds were determined by electronic circular dichroism (ECD) data analysis. Antioxidant, anti-inflammatory, and cytotoxic activities of isolated compounds were evaluated. Among them, compound 2 demonstrated significant antioxidant activity compared with ascorbic acid (VC), while compounds 2 and 4 also exhibited an equal effect to positive control cisplatin. This study on the biological activity of the new vitamin E homologues from Dendrobium nobile may indicate its potential application in the pharmaceutical and food industries.

Effects of the epiphytic patterns on endophytes and metabolites of Dendrobium nobile Lindl

“…Dendrobium nobile Lindl. is a herb that is grown in Southwest China, such as Guizhou, Sichuan, and Guangxi Provinces ( Adhikari et al., 2020 ), and plays a vital role in enhancing health with properties such as neuroprotection ( Li et al., 2022a ; Li et al., 2022b ), anti-inflammation ( Lei et al., 2022 ), antioxidation ( Long et al., 2023 ), and immune modulation ( Fan et al., 2020 ; Long et al., 2023 ). Studies have shown that D. nobile is rich in chemical components such as alkaloids, polysaccharides, phenolic acids, and flavonoids ( Ling et al., 2021 ).…”

Photoprotective Effects of Dendrobium nobile Lindl. Polysaccharides against UVB-Induced Oxidative Stress and Apoptosis in HaCaT Cells

“…It is classified as a superior product in “Shen Nong’s Herbal Classic” because of its excellent tonic properties in alleviating paralysis, lowering Qi, and tonifying the weakness of the internal organs. Previous studies on DNL have mainly focused on its small molecule components, such as phenols, alkaloids, and sesquiterpenes [ 15 , 16 , 17 , 18 ], while only a few studies have investigated its bioactive macromolecules. DNL polysaccharides (DNPs) are among the main active components of DNL, exerting antioxidant [ 19 ], anti-inflammatory [ 17 ], and anti-apoptotic effects [ 20 , 21 ].…”

Transcriptome and metabolome analysis reveals the effect of flavonoids on flower color variation in Dendrobium nobile Lindl.

“…Dendrobium contains several bioactive metabolites including: polysaccharides, alkaloids, flavonoids, amongst others ( He et al., 2020 ; Lu et al., 2022 ). These components offer various health benefits, such as antioxidation, anti-inflammation, and antitumor effects ( Lei et al., 2022 ), improvement of liver damage, and nerve protection ( Li D. et al., 2022 ). Our research group discovered variant strains of D. nobile L. that bloom pure white flowers under the same ecological conditions in which the flowers are typically purple and white.…”