Antioxidant and Anti-Inflammatory Effects of Coenzyme Q10 Supplementation on Infectious Diseases

Sifuentes-Franco, Sonia; Sánchez-Macías, Dellaneira Carolina; Carrillo-Ibarra, Sandra; Rivera-Valdés, Juan José; Zuñiga, Laura Yareni; Sánchez-López, Virginia Aleyda

doi:10.3390/healthcare10030487

Cited by 40 publications

(27 citation statements)

References 47 publications

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“…The health benefit of supplementation with CoQ 10 has been reported for many diseases including cardiovascular, neurodegenerative, neurological, and psychiatric (Gvozdjáková et al, 2014;Hernández-Camacho et al, 2021;Rauchová, 2021;Sue-Ling et al, 2022). The antiinflammatory, antioxidant properties and supporting effect on mitochondrial function helps in curing infectious diseases (Sifuentes-Franco et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Reduced platelet mitochondrial respiration and oxidative phosphorylation in patients with post COVID-19 syndrome are regenerated after spa rehabilitation and targeted ubiquinol therapy

Sumbalová

Kucharská

Rausová

et al. 2022

Front. Mol. Biosci.

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European Association of Spa Rehabilitation recommend spa rehabilitation for patients with post COVID-19 syndrome (post C-19). We studied effects of special mountain spa rehabilitation program and its combination with ubiquinol (reduced form of coenzyme Q10—CoQ10) supplementation on pulmonary function, clinical symptoms, endogenous CoQ10 levels, and platelet mitochondrial bioenergetics of patients with post C-19. 36 patients with post C-19 enrolled for rehabilitation in mountain spa resort and 15 healthy volunteers representing the control group were included in this study. 14 patients with post C-19 (MR group) were on mountain spa rehabilitation lasting 16–18 days, 22 patients (MRQ group) were supplemented with ubiquinol (2 × 100 mg/day) during the rehabilitation and additional 12–14 days at home. Clinical symptoms and functional capacity of the lungs were determined in the patients before and after the spa rehabilitation program. Platelet bioenergetics by high-resolution respirometry, plasma TBARS concentration, and CoQ10 concentration in blood, plasma and platelets were evaluated before and after the spa rehabilitation program, and in 8 patients of MRQ group also after additional 12–14 days of CoQ10 supplementation. Pulmonary function and clinical symptoms improved after the rehabilitation program in both groups, 51.8% of symptoms disappeared in the MR group and 62.8% in the MRQ group. Platelet mitochondrial Complex I (CI)-linked oxidative phosphorylation (OXPHOS) and electron transfer (ET) capacity were markedly reduced in both groups of patients. After the rehabilitation program the improvement of these parameters was significant in the MRQ group and moderate in the MR group. CI-linked OXPHOS and ET capacity increased further after additional 12–14 days of CoQ10 supplementation. CoQ10 concentration in platelets, blood and plasma markedly raised after the spa rehabilitation with ubiquinol supplementation, not in non-supplemented group. In the MRQ group all parameters of platelet mitochondrial respiration correlated with CoQ10 concentration in platelets, and the increase in CI-linked OXPHOS and ET capacity correlated with the increase of CoQ10 concentration in platelets. Our data show a significant role of supplemented ubiquinol in accelerating the recovery of mitochondrial health in patients with post C-19. Mountain spa rehabilitation with coenzyme Q10 supplementation could be recommended to patients with post C-19. This study was registered as a clinical trial: ClinicalTrials.gov ID: NCT05178225.

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Section: Discussionmentioning

confidence: 99%

Reduced platelet mitochondrial respiration and oxidative phosphorylation in patients with post COVID-19 syndrome are regenerated after spa rehabilitation and targeted ubiquinol therapy

Sumbalová

Kucharská

Rausová

et al. 2022

Front. Mol. Biosci.

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“…It reduces viral load and has been suggested as adjuvant therapy in infectious diseases. [39] Six participants (three doctors, one nurse, and two secretaries) stated that they use it.…”

Section: Discussionmentioning

confidence: 99%

Investigation of supplement products preferred by healthcare professionals during COVID-19 pandemic process

KALE>

Keskin

2023

Journal of Contemporary Medicine

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Objective: Various products are used to strengthen immunity in prevention and treatment during the COVID-19 pandemic affecting the whole world, which has no cure yet, and the vaccine has just been used. This study was planned to learn about the supplements used by healthcare professionals. Methods: A questionnaire was applied to the physicians, nurses, technicians, secretaries, and staff working in the operating room, intensive care, ward, and outpatient clinic by e-mail, WhatsApp, or face-to-face interview method. Results: There was no difference between the groups in terms of being COVID-19-positive. The most used products were primarily Mg and vitamin D, and vitamin C, ginger, Zn, turmeric, green tea, vitamin complex, thyme, black elderberry (sambucus nigra), propolis, prebiotic/probiotic, acetylsalicylic acid (ASA), black cumin (niger sativa), N-acetyl cysteine (NAC), selenium (Se), Coenzyme-Q10, cinnamon, glutathione (GSH) and quercetin respectively. No one had used alpha lipoic acid (ALA). The products that showed significant differences between the groups with and without COVID-19 were vitamin C, prebiotic/probiotic, propolis and ASA. Conclusıon: Since it is not asked when the product is used, although it is not possible to evaluate its effectiveness for preventive or therapeutic purposes, known to be natural, inexpensive, and easily accessible antiviral products may be preferred.

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“…Antioxidant defence systems comprise both enzymatic (e.g., the activity of superoxide dismutases (SOD), glutathione peroxidase (GPx), glutathione-reductase (GR), catalase (CAT), and haem oxygenase (HO)) and nonenzymatic mechanisms [ 28 , 33 , 34 ]. The The latest includes the activity of endogenous agents (e.g., glutathione (GSH), the thioredoxin system, melatonin, and coenzyme Q10) and a large group of exogenous antioxidants, which are usually provided by food, such as vitamins, polyphenols, carotenoids, and some minerals [ 19 , 35 , 36 ].…”

Section: Role Of Polyphenols As Antioxidantsmentioning

confidence: 99%

Possible Side Effects of Polyphenols and Their Interactions with Medicines

Duda-Chodak

Tarko

2023

Molecules

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Polyphenols are an important component of plant-derived food with a wide spectrum of beneficial effects on human health. For many years, they have aroused great interest, especially due to their antioxidant properties, which are used in the prevention and treatment of many diseases. Unfortunately, as with any chemical substance, depending on the conditions, dose, and interactions with the environment, it is possible for polyphenols to also exert harmful effects. This review presents a comprehensive current state of the knowledge on the negative impact of polyphenols on human health, describing the possible side effects of polyphenol intake, especially in the form of supplements. The review begins with a brief overview of the physiological role of polyphenols and their potential use in disease prevention, followed by the harmful effects of polyphenols which are exerted in particular situations. The individual chapters discuss the consequences of polyphenols’ ability to block iron uptake, which in some subpopulations can be harmful, as well as the possible inhibition of digestive enzymes, inhibition of intestinal microbiota, interactions of polyphenolic compounds with drugs, and impact on hormonal balance. Finally, the prooxidative activity of polyphenols as well as their mutagenic, carcinogenic, and genotoxic effects are presented. According to the authors, there is a need to raise public awareness about the possible side effects of polyphenols supplementation, especially in the case of vulnerable subpopulations.

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Antioxidant and Anti-Inflammatory Effects of Coenzyme Q10 Supplementation on Infectious Diseases

Cited by 40 publications

References 47 publications

Reduced platelet mitochondrial respiration and oxidative phosphorylation in patients with post COVID-19 syndrome are regenerated after spa rehabilitation and targeted ubiquinol therapy

Reduced platelet mitochondrial respiration and oxidative phosphorylation in patients with post COVID-19 syndrome are regenerated after spa rehabilitation and targeted ubiquinol therapy

Investigation of supplement products preferred by healthcare professionals during COVID-19 pandemic process

Possible Side Effects of Polyphenols and Their Interactions with Medicines

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