Antioxidant and Anti-Inflammatory Effects of Curcumin Contribute Into Attenuation of Acute Gentamicin-Induced Nephrotoxicity in Rats

Al-Kuraishy, Hayder M; Al-Gareeb, Ali I; Rasheed, Huda A

doi:10.22159/ajpcr.2019.v12i3.30875

Cited by 23 publications

(19 citation statements)

References 14 publications

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“…Curcumin could reduce the biomarkers of renal injury and renal tubule necrosis in AKI. 46 Based on the data obtained from this study, the antioxidative effects of CUR play a significant role in its renoprotective properties against PolyE nephrotoxicity. Many clinical trials showed the protective effects of CUR in human diseases.…”

Section: Discussionmentioning

confidence: 79%

<p>Curcumin Supplementation Alleviates Polymyxin E-Induced Nephrotoxicity</p>

Vazin

Heidari

Khodami

2020

JEP

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Background: The last-line agent for gram-negative bacteria that have developed resistance towards commonly used antibiotics is polymyxin E (PolyE). The renal toxicity attributed to this agent limits its use, proper dosing, and eventually its clinical efficacy. Although the exact mechanism of PolyE-induced nephrotoxicity is not obvious, some investigations suggest the role of oxidative stress and its associated events in this complication. Curcumin (CUR) is a potent antioxidant molecule. The aim of the current investigation was the evaluation of the potential nephroprotective properties of CUR in PolyE-treated mice. Materials and Methods: Mice were randomly allocated into five groups (n = 8 per group). PolyE (15 mg/kg/day, i.v, for 7 days) alone or in combination with CUR (10, 100 and 200 mg/kg, i.p) were administered to mice. Renal injury biomarkers, in addition to markers of oxidative stress and kidney histopathological alterations, were evaluated. Results: Plasma creatinine (Cr) and blood urine nitrogen (BUN) significantly raised in PolyE group. Oxidative stress biomarkers consisting of reactive oxygen species (ROS) and lipid peroxidation (LPO) also increased, and concomitantly GSH and antioxidant capacity of renal cells significantly decreased following the use of PolyE. Interstitial nephritis, tissue necrosis, and glomerular atrophy were all induced by the use of PolyE in the mice kidney. CUR (10, 100, and 200 mg/kg, i.p) treatment alleviated PolyE-induced oxidative stress and histopathological alterations in the kidney tissue significantly. Conclusion: According to the results of this study, CUR has a protective role against renal toxicity induced by PolyE. Hence, more research is necessary until this compound could be clinically applicable to alleviate PolyE-induced renal injury.

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Section: Discussionmentioning

confidence: 79%

<p>Curcumin Supplementation Alleviates Polymyxin E-Induced Nephrotoxicity</p>

Vazin

Heidari

Khodami

2020

JEP

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“…SOX genes can regulate a number of developmental processes including lens, hair follicle, gut, B-cell, muscle, and blood vessel development [12].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Sex-Determining Region Y-Box 2 (Sox2) in Prostate Cancer

Mohasen¹,

Ahmed²

2019

Asian J Pharm Clin Res

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Objectives: The objectives of this study were to evaluate the expression of sex-determining region-Y BOX 2 (SOX2) markers and their association with clinicopathological parameters. Methods: A cross-sectional study was carried out to involve 90 specimens from patients diagnosed with prostatic cancer (PC) and benign prostatic hypertrophy (BPH) compared with positive control (human bronchial tissue for SOX2 marker) with each run. Results: The highest proportion of specimens of PC was graded ≤7 by Gleason grading system (53.3%). There were significant associations (p<0.05) between all this cancer stem cell marker results and prevalence of PC. Positive SOX2 marker result was significantly associated with bad prognostic sign (81.3%, p=0.001). This marker was highly sensitive (100%) specificity (82.4%), with high accuracy (90%). Conclusion: There was a significant expression of SOX2 in prostate adenocarcinomas. SOX2 can be considered as a key regulator of tumor progression, aggressive behavior, and metastasis. Furthermore, it is a reliable marker for the early diagnosis and the designed chemotherapy of prostate adenocarcinomas.

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“…Body mass index (BMI) equal to body weight in grams over the square of length in cm, BMI = BW (grams)/length (cm). [214]…”

Section: Methodsmentioning

confidence: 99%

“…Nephrotoxic drugs lead to acute injury of proximal renal tubules through activation of oxidative stress and interference with renal tubular transport processes. [2]…”

Section: Introductionmentioning

confidence: 99%

Synergistic effect of berberine and pentoxifylline in attenuation of acute kidney injury

Al-Kuraishy

Al-Gareeb

Hussien

2019

Int J Crit Illn Inj Sci

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Objective: To evaluate the renoprotective effects of berberine and/or pentoxifylline in reduction of diclofenac-induced acute kidney injury (AKI) in rats. Material and Methods: Fifty male Sprague-Dawley rats were allocated into five groups, Group 1: Rats treated with distilled water plus normal saline for 12 days. Group 2: Rats treated with distilled water plus diclofenac for 12 days. Group 3: Rats treated with berberine plus diclofenac for 12 days. Group 4: Rats treated with pentoxifylline plus diclofenac for 12 days. Group 5: Rats treated with berberine + pentoxifylline plus diclofenac 15 mg/kg for 12 days. Blood urea, creatinine, neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecules (KIM-1), and cystatin-c were used to measure the severity of AKI. Results: Diclofenac led to significant AKI by significant elevation of blood urea, serum creatinine, KIM-1, and NGAL. Treatment with berberine showed no significant effect on all biomarkers level compared to diclofenac group except on serum KIM-1 level which also seen in the pentoxifylline group whereas combination of berberine and pentoxifylline led to more significant effect in the reduction of all renal biomarkers. Conclusion: Combination of berberine with pentoxifylline illustrated a synergistic effect in attenuation of diclofenac-induced AKI.

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Antioxidant and Anti-Inflammatory Effects of Curcumin Contribute Into Attenuation of Acute Gentamicin-Induced Nephrotoxicity in Rats

Cited by 23 publications

References 14 publications

<p>Curcumin Supplementation Alleviates Polymyxin E-Induced Nephrotoxicity</p>

<p>Curcumin Supplementation Alleviates Polymyxin E-Induced Nephrotoxicity</p>

Prognostic Value of Sex-Determining Region Y-Box 2 (Sox2) in Prostate Cancer

Synergistic effect of berberine and pentoxifylline in attenuation of acute kidney injury

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