Antioxidant and anti-inflammatory properties of Chinese ilicifolius vegetable (Acanthopanax trifoliatus (L) Merr) and its reference compounds

Abstract

Stems and leaves of Acanthopanax trifoliatus (L) Merr (AT) are commonly used as an edible vegetable in China. The scientific basis of antioxidant and antiinflammatory activities of AT was investigated. The polyphenol contents and free radical scavenging activities of AT ethanol extracts (EAT) were determined. Chlorogenic acid, isochlorogenic acid A, isochlorogenic acid C, and rutin were identified as major components in EAT. LPS-induced NO production in RAW264.7 cells was decreased significantly (p<0.05) after EAT treatment, compared with controls. In vivo studies indicated that EAT had more activity than chlorogenic acid per mg of dry weight for inhibition of TPA-induced ear edema. TPA-induced increases in cytokine production (TNF-α, IL-6, MMP-9, and TIMP-1) were significantly (p<0.05) reduced by EAT treatment, compared with controls. EAT exerts anti-inflammatory activities probably due, at least in part, to chlorogenic acid.

Predictive study of the Bioconcentration of Organochlorine Compounds by a QSPR Model

“…After analysis of monguba seeds, 21 phenolic compounds were quantified, among other, higher levels in the phenolic acids, such as 2,5-dihydroxybenzoic acid, caffeic acid, ferulic acid gallic acid, homogentisic acid, p-coumaric acid, and especially chlorogenic acid. Chlorogenic acid is compound derived from caffeic acid and it exhibits several beneficial biological properties, including antibacterial, antiphlogistic, antiviral, and inhibitory effects on carcinogenesis in the large intestine and liver [59,60]. The chlorogenic acid values found in our study were higher than those contents reported for Gordon et al [61] in açaí pulp (0.2 to 16.4 μg/g dry basis).…”

Bioactive compounds of 44 traditional and exotic Brazilian fruit pulps: phenolic compounds and antioxidant activity

“…Chlorogenic acid is widely distributed in fruits, having several beneficial biological properties, including antibacterial, antiphlogistic, antiviral, and inhibitory effects on carcinogenesis in the large intestine and liver. [40,41] Studies by Pingret et al [42] and Hao et al [41] have shown that apple contains considerable amounts of hydroxycinnamic acid derivatives which are represented mainly by chlorogenic acid. Hydroxycinnamic acids are generally found primarily esterified with small molecules, as well as bound to cell wall structural components, such as cellulose, lignin and proteins, through ester bonds.…”

Proximate composition, vitamin and mineral composition, antioxidant capacity, and anticancer activity of Acanthopanax trifoliatus

“…It has been used as both traditional plant food and medicinal plant. [ 1 2 3 4 5 6 ] As plant food, people of Thailand consume Phak-pam as a vegetable. As a medicinal plant, Phak-pam has been reported as ginseng-like plant.…”

“…[ 5 ] It also possessed pharmacological effects, for instance, anti-inflammatory, antioxidant, and anticancer properties. [ 1 2 3 4 5 6 ] Plant food provides nutrients that help maintain the body functions. Nowadays, nutritional information is increasingly concern for many reasons, for example, to meet nutritional requirements or to prevent nutritional deficiency disease.…”

“…[ 10 ] Some bioactive compounds in the food plant has a natural antioxidant capacity, especially polyphenols, to scavenge free radicals. [ 3 10 11 ] Oxygen radical absorbance capacity (ORAC) measures the effectiveness of chain-breaking antioxidants, while ferric reducing antioxidant power (FRAP) measures the action of the electron donation from antioxidants (the reducing capacity of antioxidants). [ 10 11 12 13 14 ] Cancer is a disease differentiated by the uncontrolled growth and spread of abnormal cells.…”