Antioxidant and Anti-Inflammatory Properties of Plants Extract

Allegra, Mario

doi:10.3390/antiox8110549

Cited by 28 publications

(24 citation statements)

References 22 publications

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“…In our assessment of antioxidant activity, the extracts eE006 and hE006 displayed significantly lower TPCs than other extracts of the same extraction solvent in the extract library (5.06 and 0.61 mg chlorogenic acid equivalent/g extract), as well as no EC 50 value reached in the DPPH assay. We therefore hypothesize that the mechanism of action for the COX-2 inhibition is not due to free radical scavenging and high phenol content, as often proposed for antiinflammatory medicinal plants [ 79 , 80 , 81 , 82 ]. Extract hE006 exhibited moderate antibacterial activity against multidrug-resistant S. aureus (MIC: 125 µg/mL) and no inhibitory activity against L. innocua (MIC: >500 µg/mL), whereas extract eE006 showed low antibacterial activity against S. aureus and L. innocua (MIC: 500 µg/mL).…”

Section: Discussionmentioning

confidence: 91%

“…Phenolic compounds are often thought to possess antiinflammatory properties. The mechanisms of action of many phenolic compounds are most likely associated with their inhibition of proinflammatory enzymes in the arachidonic acid pathway (e.g., COX-2 and 5-LOX) or with their free radical scavenging activity [ 79 , 80 , 81 , 82 ]. Except for extract etE009 (relatively high TPC), none of the nine extracts that exhibited high COX-2 inhibition activity showed an increased antioxidant activity or calculated TPC compared to the other extracts in the library.…”

Section: Discussionmentioning

confidence: 99%

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Antiinflammatory Medicinal Plants from the Ugandan Greater Mpigi Region Act as Potent Inhibitors in the COX-2/PGH2 Pathway

Schultz

Osuji

Wack

et al. 2021

Plants

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Our study investigates 16 medicinal plants via assessment of inhibition of proinflammatory enzymes such as cyclooxygenases (COX). The plants are used by traditional healers in the Greater Mpigi region in Uganda to treat inflammation and related disorders. We present results of diverse in vitro experiments performed with 76 different plant extracts, namely, (1) selective COX-2 and COX-1 inhibitor screening; (2) 15-LOX inhibition screening; (3) antibacterial resazurin assay against multidrug-resistant Staphylococcus aureus, Listeria innocua, Listeria monocytogenes, and Escherichia coli K12; (4) DPPH assay for antioxidant activity; and (5) determination of the total phenolic content (TPC). Results showed a high correlation between traditional use and pharmacological activity, e.g., extracts of 15 out of the 16 plant species displayed significant selective COX-2 inhibition activity in the PGH2 pathway. The most active COX-2 inhibitors (IC50 < 20 µg/mL) were nine extracts from Leucas calostachys, Solanum aculeastrum, Sesamum calycinum subsp. angustifolium, Plectranthus hadiensis, Morella kandtiana, Zanthoxylum chalybeum, and Warburgia ugandensis. There was no counteractivity between COX-2 and 15-LOX inhibition in these nine extracts. The ethyl acetate extract of Leucas calostachys showed the lowest IC50 value with 0.66 µg/mL (COX-2), as well as the most promising selectivity ratio with 0.1 (COX-2/COX-1). The TPCs and the EC50 values for DPPH radical scavenging activity showed no correlation with COX-2 inhibitory activity. This led to the assumption that the mechanisms of action are most likely not based on scavenging of reactive oxygen species and antioxidant activities. The diethyl ether extract of Harungana madagascariensis stem bark displayed the highest growth inhibition activity against S. aureus (MIC value: 13 µg/mL), L. innocua (MIC value: 40 µg/mL), and L. monocytogenes (MIC value: 150 µg/mL). This study provides further evidence for the therapeutic use of the previously identified plants used medicinally in the Greater Mpigi region.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Antiinflammatory Medicinal Plants from the Ugandan Greater Mpigi Region Act as Potent Inhibitors in the COX-2/PGH2 Pathway

Schultz

Osuji

Wack

et al. 2021

Plants

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“…Historically, all medicinal preparations were derived from plants, whether as plant parts (leaf, rhizome, roots, stem, bark or fruits) or as crude extracts or mixtures. Plant extracts contain a number of bioactive compounds of different classes, including alkaloids, terpenoids, and polyphenols, possess numerous activities, such as antibacterial, antiviral, antifungal, antioxidant, anti-inflammatory, and anti-obesity [9][10][11][12][13][14], and have been used in various disorders, such as cardiovascular diseases, rheumatoid arthritis, osteoporosis, and skin diseases [15][16][17][18][19]. During the last few decades, the use of traditional medicine has expanded globally and has gained popularity as primary health care in developing countries, and in countries where conventional medicine is predominant [20].…”

Section: Introductionmentioning

confidence: 99%

Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

Sitarek

Merecz-Sadowska

Kowalczyk

et al. 2020

IJMS

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The skin is an important organ that acts as a physical barrier to the outer environment. It is rich in immune cells such as keratinocytes, Langerhans cells, mast cells, and T cells, which provide the first line of defense mechanisms against numerous pathogens by activating both the innate and adaptive response. Cutaneous immunological processes may be stimulated or suppressed by numerous plant extracts via their immunomodulatory properties. Several plants are rich in bioactive molecules; many of these exert antimicrobial, antiviral, and antifungal effects. The present study describes the impact of plant extracts on the modulation of skin immunity, and their antimicrobial effects against selected skin invaders. Plant products remain valuable counterparts to modern pharmaceuticals and may be used to alleviate numerous skin disorders, including infected wounds, herpes, and tineas.

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“…7 There are complex and often positive connections between oxidative stress with the inflammatory response given as a result of tissue injury and infection. 8 Guava leaves are used as traditional medicines for the treatment of diabetes; they lowered levels of cholesterol, sugar, triglycerides, malonaldehyde and glycated serum protein in the blood of streptozotocin-induced diabetic mice according to their ABTS, OH and DPPH free radical scavenging capabilities. 9 Reactive oxygen species are one of the main causes of Alzheimer disease, as a result, any agent that blocks their generation, can be useful in treating the disease.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Assisted Synthesis, Antioxidant Activity and Computational Study of 1,3,4-Oxadiazol-2-amines

Beyzaei

Sargazi

Bagherzade

et al. 2021

ACSi

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Development of synthetic procedures for the preparation of 1,3,4-oxadiazole derivatives has always been in the interest of researchers as a result of their widespread biological activities. In this study, an ultrasound-assisted procedure was proposed for the synthesis of 1,3,4-oxadiazol-2-amines form the reaction of hydrazides and cyanogen bromide. They were efficiently produced in 81–93% yields in the presence of ethanol and potassium bicarbonate as the reaction media and the base, respectively. Their antioxidant properties were determined via DPPH free radical scavenging method as one of the most basic steps in identifying other related biological effects. IC50 values were in the range of from 0.237 to 0.863 mM. The synthesized 1,3,4-oxadiazoles are protective agents against oxidative stress, and can be used in the treatment of cancer, candidiasis, diabetes, neurodegenerative and inflammatory diseases. Furthermore, bond dissociation energies (BDEs) and electron densities based NCI (non-covalent interactions) were calculated using density-functional theory (DFT) to understand the observed reactivities. It was found that reversible dipole-dipole forces play a key role in most interactions.

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Antioxidant and Anti-Inflammatory Properties of Plants Extract

Abstract: Inflammation is an adaptive response triggered by noxious stimuli and conditions such as infection and tissue injury [...]

Cited by 28 publications

References 22 publications

Antiinflammatory Medicinal Plants from the Ugandan Greater Mpigi Region Act as Potent Inhibitors in the COX-2/PGH2 Pathway

Antiinflammatory Medicinal Plants from the Ugandan Greater Mpigi Region Act as Potent Inhibitors in the COX-2/PGH2 Pathway

Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

Ultrasound-Assisted Synthesis, Antioxidant Activity and Computational Study of 1,3,4-Oxadiazol-2-amines

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