Antioxidant and anti-melanogenesis activities of extracts from
            <i>Leonurus japonicus</i>
            Houtt

Zhang, Lin; Khoo, Cheang; Xiahou, Zhikai; Reddy, N. Venkata; Li, Yue; Lv, Jingjing; Sun, Meihe; Fan, Heming; Zhang, Xian

doi:10.1080/02648725.2023.2202544

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…A considerable amount of research shows that in in vitro experiments, Leo can inhibit transcription factor AP1 in Hep G2 hepatocellular carcinoma cells through the Mitogen-Activated Protein Kinase (MAPK) signaling pathway, reduce the expression of matrix metalloproteinase-3 (MMP-3), thereby significantly reducing the number of cells passing through the polycarbonate membrane and effectively inhibiting cell invasion and metastasis. This further proves that Leo inhibits the activity of matrix metalloproteinases MMPs, reducing the degradation of extracellular matrix components and inhibiting the invasion and metastasis of liver cancer cells ( Gao et al, 2022 ; Kumar et al, 2019 ; Zhang et al, 2023 ).…”

Section: Main Antitumor Mechanisms Of Leomentioning

confidence: 55%

A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid

Cao,

Wang,

et al. 2023

Front. Pharmacol.

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Leonurine refers to the desiccated aerial portion of a plant in the Labiatae family. The primary bioactive constituent of Leonurine is an alkaloid, Leonurine alkaloid (Leo), renowned for its substantial therapeutic efficacy in the treatment of gynecological disorders, in addition to its broad-spectrum antineoplastic capabilities. Over recent years, the pharmacodynamic mechanisms of Leo have garnered escalating scholarly interest. Leo exhibits its anticancer potential by means of an array of mechanisms, encompassing the inhibition of neoplastic cell proliferation, induction of both apoptosis and autophagy, and the containment of oncogenic cell invasion and migration. The key signal transduction pathways implicated in these processes include the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL), the Phosphoinositide3-Kinase/Serine/Threonine Protein Kinase (PI3K/AKT), the Signal Transducer and Activator of Transcription 3 (STAT3), and the Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase (MAP/ERK). This paper commences with an exploration of the principal oncogenic cellular behaviors influenced by Leo and the associated signal transduction pathways, thereby scrutinizing the mechanisms of Leo in the antineoplastic sequence of events. The intention is to offer theoretical reinforcement for the elucidation of more profound mechanisms underpinning Leo’s anticancer potential and correlating pharmaceutical development.

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Section: Main Antitumor Mechanisms Of Leomentioning

confidence: 55%

A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid

Cao,

Wang,

et al. 2023

Front. Pharmacol.

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“…Polysaccharides obtained from Stichopus japonicus interfered with ERK activation, further suppressing MITF expression in vitro [ 43 ]. In addition, polysaccharide extract from Leonurus japonicus shows anti-tyrosinase activities in an oxidative-stressed model, and modulates MITF via PI3K-Akt and β-catenin pathway [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Tricholoma matsutake polysaccharides suppress excessive melanogenesis via JNK-mediated pathway: Investigation in 8- methoxypsoralen induced B16–F10 melanoma cells and clinical study

Yang,

Lv,

et al. 2024

Heliyon

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“…LJP showed mild anticoagulant activity, low toxicity, and less spontaneous bleeding compared with heparin sodium (Hu et al 2020 ). Therefore, it is of practical significance for optimizing the extraction conditions of LJP to further study LJP activity (Zhang et al 2023).…”

Section: Introductionmentioning

confidence: 99%

Optimization of deep eutectic-like solvent-based ultrasound-assisted extraction of polysaccharides from Leonurus residues

Yuan,

Wei,

Sun

et al. 2024

BioRes

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Effects of the different types of deep eutectic-like solvents (DESs), molar ratio, water content, extraction temperature, extraction time, and ratio of liquid to solid were studied relative to the yield of Leonurus residue crude polysaccharide (LRCP). Extraction amounts of LRCP were determined. The extraction process parameters were optimized by response surface methodology, and an optimal extraction process was achieved. The results showed that DESs comprising choline chloride and ethylene glycol (CCEG) were suitable for the extraction. The optimum extraction process was as follows: water content, 27%; extraction temperature, 62 °C; and extraction time, 48 min. With the abovementioned parameters, the predicted extraction yield of LRCP was 14.1%. It was found that with these optimal extraction conditions, a 52.9% higher extraction yield could be achieved compared with hot water extraction. Therefore, a type of DES was found to be an excellent extraction solvent alternative for the extraction of polysaccharides and has a practical value.

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Antioxidant and anti-melanogenesis activities of extracts from Leonurus japonicus Houtt

Cited by 3 publications

References 45 publications

A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid

A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid

Tricholoma matsutake polysaccharides suppress excessive melanogenesis via JNK-mediated pathway: Investigation in 8- methoxypsoralen induced B16–F10 melanoma cells and clinical study

Optimization of deep eutectic-like solvent-based ultrasound-assisted extraction of polysaccharides from Leonurus residues

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