Antioxidant and Anti-nitric Oxide Components from &lt;i&gt;Quercus glauca&lt;/i&gt;

Shen, Chien‐Chang; Hong, Kun‐Yuan; Chen, Jennifer; Zhang, Lijie; Zhang, Lin; Huang, Hung‐Tse; Cheng, Hui‐Ling; Kuo, Yao‐Haur

doi:10.1248/cpb.c12-00174

Cited by 14 publications

(5 citation statements)

References 27 publications

(26 reference statements)

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“…Compounds 5 , 10 , and 12 showed moderate DPPH radical scavenging activities with IC 50 values of 42.6 ± 1.8, 57.0 ± 2.3, and 59.5 ± 3.5 μM, respectively, whereas the other compounds (IC 50 > 100 μM) did not display significant DPPH radical scavenging activity (Table ). These results are comparable to those of previously isolated neolignan in other studies. , Zhao et al reported that two new neolignan glycosides (IC 50 > 100 μM) from Pittosporum glabratum were inactive in the DPPH radical scavenging assay . A comparison of the structures of 5 , 10 , and 12 with those of 15 , 8 , and 11 indicated that additional methoxy groups at C-5 positions appeared to increase the antioxidant activity of the dihydrobenzofuran neolignans.…”

Section: Resultssupporting

confidence: 86%

“…These results are comparable to those of previously isolated neolignan in other studies. 44,45 Zhao et al reported that two new neolignan glycosides (IC 50 > 100 μM) from Pittosporum glabratum were inactive in the DPPH radical scavenging assay. 46 A comparison of the structures of 5, 10, and 12 with those of 15, 8, and 11 indicated that additional methoxy groups at C-5 positions appeared to increase the antioxidant activity of the dihydrobenzofuran neolignans.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Antioxidant and Anti-inflammatory Active Dihydrobenzofuran Neolignans from the Seeds of Prunus tomentosa

Liu

Huang²,

Bai³

et al. 2014

J. Agric. Food Chem.

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Prunus tomentosa seeds were researched for antioxidant and anti-inflammatory constituents. By activity-guided fractionation of P. tomentosa seed extract, six new dihydrobenzofuran neolignans, prunustosanans AI-IV (1-4) and prunustosanansides AI and AII (5 and 6), together with 10 known compounds (7-16) were isolated from bioactive fraction. The structures were determined by spectroscopic analyses, especially NMR, HRESIMS, and CD spectra. The antioxidant activity was greatest for 5, 10, and 12 against DPPH radical and for 8, 9, and 13 against ABTS radical. Moreover, compounds 7 and 11 exhibited much stronger inhibitory activity on nitric oxide (NO) production in murine microglia BV-2 compared with positive control minocycline (IC50 = 19.7 ± 1.5 μM). The results show that P. tomentosa seeds can be regarded as a potential source of antioxidants and inflammation inhibitors.

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Section: Resultssupporting

confidence: 86%

Section: ■ Materials and Methodsmentioning

confidence: 99%

Antioxidant and Anti-inflammatory Active Dihydrobenzofuran Neolignans from the Seeds of Prunus tomentosa

Liu

Huang²,

Bai³

et al. 2014

J. Agric. Food Chem.

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“…), Fagaceae, or the “ring-cup oak”, is native to subtropical and warmer temperate zones of Asia. It contains a variety of tannins (catechins, procyanidins, gallic acids), triterpenoids, flavonoid glycosides and steroids (cycloartanols, stigmastanes) (Kamano et al, 1976, Shen et al, 2012, Sheu et al, 1992, Suga and Kondo, 1974, Wakamatsu et al, 2020)). Schima superba Gardner & Champ., Theaceae, is a dominant broad-leaved evergreen tree distributed over temperate Asia.…”

Section: Methodsmentioning

confidence: 99%

Plot diversity differentially affects the chemical composition of leaves, roots and root exudates in four subtropical tree species

Weinhold

Döll

Liu

et al. 2020

Preprint

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Plants produce thousands of compounds, collectively called the metabolome, which mediate interactions with other organisms. The metabolome of an individual plant may change according to the number and nature of these interactions. We tested the hypothesis that tree diversity level affects the metabolome of four subtropical tree species in a biodiversity ecosystem-functioning experiment, BEF-China. We postulated that the chemical diversity of leaves, roots and root exudates increases with tree diversity. We expected the strength of this diversity effect to differ among leaf, root and root exudates samples. Considering their role in plant competition, we expected to find the strongest effects in root exudates.In an ecometabolomics approach, roots, root exudates and leaves of four tree species (Cinnamomum camphora, Cyclobalanopsis glauca, Daphniphyllum oldhamii, Schima superba) were sampled from selected plots in BEF-China. Samples were extracted and analysed using Liquid Chromatography-Time of Flight-Mass Spectrometry. The exudate metabolomes were normalized over their non-purgeable organic carbon level. Multivariate analyses were applied to identify the effect of both neighbouring (local) trees and plot diversity on tree metabolomes. The species and sample specific metabolites were assigned to major compound classes using the ClassyFire tool, whereas m/z features related to diversity effects were annotated manually.Individual tree species showed distinct leaf, root and root exudate metabolomes. The main compound class in leaves were the flavonoids, whereas carboxylic acids, prenol lipids and specific alkaloids were most prominent in root exudates and roots. Overall plot diversity had a stronger effect on metabolome profiles than the diversity of local, directly neighbouring trees. Leaf metabolomes responded more often to tree diversity level than exudates, whereas root metabolomes varied the least. We found not overall correlation between metabolite richness or diversity and tree diversity.Synthesis: Classification of metabolites supported initial ecological interpretation of differences among species and organs. Particularly the metabolomes of leaves and root exudates respond to differences in tree diversity. These responses were neither linear nor uniform and individual metabolites showed different dynamics. More controlled interaction experiments are needed to dissect the causes and consequences of the observed shifts in plant metabolomes.

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“…The known isolated compounds were identified as 1,3,6-tri- O -galloyl-β- d -glucopyranoside, 3 , 1,2,6-tri- O -galloyl-β- d -glucopyranoside, 4 , 1,2,3-tri- O -galloyl-β- d -glucopyranoside, 5 , 1,2,3,6-tetra- O -galloyl-β- d -glucopyranoside, 6 , 1,2,3,4,6-penta- O -galloyl-β- d -glucopyranoside, 7 , tellimagrandin II, 8 , (7 R ,8 S )-dihydrodehydrodiconiferyl alcohol, 9 , (7 S ,8 R )-dihydrodehydrodiconiferyl alcohol-9-β- d -glucopyranoside, 10 , (7 S ,8 R )-dihydrodehydrodiconiferyl alcohol-9′-β- d -glucopyranoside, 11 , (7 S ,8 R )-urolignoside, 12 , (+)-isolariciresinol, 13 , naringenin, 15 , naringenin 7- O -β- d -glucopyranoside, 16 , 4-hydroxybenzoic acid, 18 , gallic acid, 19 , methyl gallate, 20 , ethyl gallate, 21 , trans - p -hydroxycinnamic acid, 22 , caffeic acid, 23 , and 4-allyl-2-methoxyphenyl-β- d -glucopyranoside, 24 . These compounds were elucidated by comparing their NMR analysis and physical data with literature data.…”

Section: Resultsmentioning

confidence: 99%

Hypoglycemic Constituents Isolated from Trapa natans L. Pericarps

Huang

Chao

Liaw³

et al. 2016

J. Agric. Food Chem.

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Trapa natans L., called water chestnut or water caltrop, is a floating aquarium plant. Its fruits are widely used as food. Two new tannins, 1 and 2, one new neolignan, 14, one new norlignan, 17, and 20 known compounds, 3-13, 15, 16, and 18-24 were isolated from T. natans pericarps in this study. The 1, 2, 14, and 17 structures were elucidated using a chemical method and extensive spectral evidence. A series of hydrolyzable tannins, 1-8, a lignin, 13, a flavonoid, 16, a norlignan, 17, and phenolic compounds, 18, 20, 21, and 24 resulted in the enhanced glucose uptake activity in C2C12 myotubes. Compounds 4 and 5 significantly increased GLUT4 protein expression in C2C12 myotubes. In addition, 4 and 5 improved the phosphorylation of AMPK, AKT(S473), and AKT(T308). The involvement of AMPK and PI3K in the mechanism of action of compounds 4 and 5 was confirmed by use of AMPK and PI3K inhibitors, which completely suppressed the 4- and 5-mediated activities of glucose uptake in C2C12 myotubes. We also demonstrated that 4 and 5 could increase GLUT4 protein levels in plasma membranes.

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Antioxidant and Anti-nitric Oxide Components from <i>Quercus glauca</i>

Cited by 14 publications

References 27 publications

Antioxidant and Anti-inflammatory Active Dihydrobenzofuran Neolignans from the Seeds of Prunus tomentosa

Antioxidant and Anti-inflammatory Active Dihydrobenzofuran Neolignans from the Seeds of Prunus tomentosa

Plot diversity differentially affects the chemical composition of leaves, roots and root exudates in four subtropical tree species

Hypoglycemic Constituents Isolated from Trapa natans L. Pericarps

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