Antioxidant and Anti‐Pollution Effect of Naturally Occurring Carotenoids Astaxanthin and Crocin for Human Skin Protection

Ácsová, Aneta; Hojerová, Jarmila; Hergesell, Kristýna; Hideg, Éva; Csepregi, Kristóf; Bauerová, Katarína; Pružinská, Katarína; Martiniaková, Silvia

doi:10.1002/slct.202201595

Cited by 3 publications

(2 citation statements)

References 60 publications

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“…These range from the clinical treatment of erythropoetic protoporhyria (EPP) and its use as a sunscreen (inhibitor of sunburn) to possible deleterious effects of skin cancers. The major carotenoid used for skin photoprotection is β-carotene, although several others such as zeaxanthin (zea), lutein (lut), and astaxanthin (ast) [43,44] have been studied. But, the value of such dietary supplementation for protection against sunlight is controversial.…”

Section: Carotenoids In the Skinmentioning

confidence: 99%

“…In recent studies, Ascova et al [44] used four in vitro oxidative stress models to study the antioxidant/antipollution effects of all-trans-astaxanthin and crocin compared to other antioxidants (alpha-tocopherol, butylhydroxytoluene, butylhydroxyanisole, gallic acid and Trolox). In general, there was little difference between the two carotenoids, apart from the skin explant studies which showed ast to be the most efficient anti-oxidant in the skin explant studies.…”

Section: Carotenoids In the Skinmentioning

confidence: 99%

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Photochemical and Photophysical Properties of Carotenoids and Reactive Oxygen Species: Contradictions Relating to Skin and Vision

Boehm¹,

Edge

Truscott

2023

Oxygen

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Molecular mechanisms based on photo-physical processes involving dietary carotenoids, their radicals, and the role of oxygen are discussed and used to suggest explanations of the poorly understood and often contradictory results related to mainly skin and vision. Differing and conflicting efficiencies of singlet oxygen reactions with carotenoids of biological importance are discussed in environments from ‘simple’ organic solvents to single He La cells. A range of free radical reactions with carotenoids, and the corresponding radicals of the carotenoids themselves, are compared and used to explain the switch from beneficial to deleterious processes involving dietary carotenoids and to unravel their differing functions; of particular interest is a possible role for vitamin C.

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Section: Carotenoids In the Skinmentioning

confidence: 99%

Section: Carotenoids In the Skinmentioning

confidence: 99%

Photochemical and Photophysical Properties of Carotenoids and Reactive Oxygen Species: Contradictions Relating to Skin and Vision

Boehm¹,

Edge

Truscott

2023

Oxygen

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Krill oil: nutraceutical potential in skin health and disease

Duo,

Yang,

Wang

et al. 2024

Front. Nutr.

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Krill oil (KO), extracted from the Antarctic marine crustacean Euphausia superba, is a nutrient-dense substance that includes rich profiles of n-3 polyunsaturated fatty acids (n-3 PUFAs), phospholipids (PLs), astaxanthin (ASX), as well as vitamins A and E, minerals, and flavonoids. As a high-quality lipid resource, KO has been widely used as a dietary supplement for its health-protective properties in recent years. KO has various benefits, including antioxidative, anti-inflammatory, metabolic regulatory, neuroprotective, and gut microbiome modulatory effects. Especially, the antioxidant and anti-inflammatory effects make KO have potential in skin care applications. With increasing demands for natural skin anti-aging solutions, KO has emerged as a valuable nutraceutical in dermatology, showing potential for mitigating the effects of skin aging and enhancing overall skin health and vitality. This review provides an overview of existing studies on the beneficial impact of KO on the skin, exploring its functional roles and underlying mechanisms through which it contributes to dermatological health and disease management.

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Astaxanthin, Compared to Other Carotenoids, Increases the Efficacy of Methotrexate in Rat Adjuvant Arthritis

Pružinská,

Chrastina,

Khademnematolahi

et al. 2024

IJMS

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This in vivo study performed in rat adjuvant arthritis aims to advance the understanding of astaxanthin’s therapeutic properties for the possible treatment of rheumatoid arthritis (RA) in monotherapy and along with the standard RA treatment, methotrexate (MTX), in combination therapy. The main goal was to elucidate astaxanthin’s full therapeutic potential, evaluate its dose dependency, and compare its effects in monotherapy with other carotenoids such as β-carotene and β-cryptoxanthin (KXAN). Moreover, potential differences in therapeutic activity caused by using different sources of astaxanthin, synthetic (ASYN) versus isolated from Blakeslea trispora (ASTAP), were evaluated using one-way ANOVA (Tukey-Kramer post hoc test). KXAN was the most effective in reducing plasma MMP-9 levels in monotherapy, significantly better than MTX, and in reducing hind paw swelling. The differences in the action of ASTAP and ASYN have been observed across various biometric, anti-inflammatory, and antioxidative parameters. In combined therapy with MTX, the ASYN + MTX combination proved to be better. These findings, especially the significant anti-arthritic effect of KXAN and ASYN + MTX, could be the basis for further preclinical studies.

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Antioxidant and Anti‐Pollution Effect of Naturally Occurring Carotenoids Astaxanthin and Crocin for Human Skin Protection

Cited by 3 publications

References 60 publications

Photochemical and Photophysical Properties of Carotenoids and Reactive Oxygen Species: Contradictions Relating to Skin and Vision

Photochemical and Photophysical Properties of Carotenoids and Reactive Oxygen Species: Contradictions Relating to Skin and Vision

Krill oil: nutraceutical potential in skin health and disease

Astaxanthin, Compared to Other Carotenoids, Increases the Efficacy of Methotrexate in Rat Adjuvant Arthritis

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