Antioxidant and Anti-Proliferative Activity of Calamintha officinalis Extract on Breast Cancer Cell Line MCF-7

Moattar, Fatemeh Shams; Sariri, Reyhaneh; Giahi, Masoud; Yaghmaee, Prichehr; Ghafoori, Hossein; Jamalzadeh, Leila

doi:10.3923/jbs.2015.194.198

Cited by 7 publications

(7 citation statements)

References 13 publications

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“…Calamintha officinalis is native to the northern part of Iran [ 26 ]. It is widely distributed in Southern and Central Europe, Western Asia, and North Africa [ 27 ].…”

Section: Lamiaceae Species Used For Diabetesmentioning

confidence: 99%

Potential Application of Some Lamiaceae Species in the Management of Diabetes

Etsassala

Hussein

Nchu

2021

Plants

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Diabetes is one of the most dangerous metabolic disorders, with high rates of mortality worldwide. Since ancient times, medicinal plants have been used in traditional medicine to treat many diseases, including diabetes and its related complications. Plants are widely accepted, affordable, and perceived to have minimal adverse side effects. The Lamiaceae family is a potential source of therapeutic agents for the management of metabolic disorders, including diabetes. Hence, this review paper summarizes the antidiabetic use of Lamiaceae species in folk medicine globally. Furthermore, we present the antidiabetic activities and phytochemical constituents of twenty-three (23) Lamiaceae species and the antidiabetic activity of some notable chemical constituents isolated from some of these Lamiaceae species.

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“…Calamintha officinalis is native to the northern part of Iran [ 26 ]. It is widely distributed in Southern and Central Europe, Western Asia, and North Africa [ 27 ].…”

Section: Lamiaceae Species Used For Diabetesmentioning

confidence: 99%

Potential Application of Some Lamiaceae Species in the Management of Diabetes

Etsassala

Hussein

Nchu

2021

Plants

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“…In addition, a zymogram assay of peroxidase (POX) was performed to observe its activity. POX activity was observed as a brown color band and two separate bands were also observed, indicating at least two isoenzymes for POX [ 172 ].…”

Section: Antioxidant Properties Of Eocnmentioning

confidence: 99%

“…Antiproliferative activity of the plant extract from Iranian material was examined on human breast cancer cell line (MCF-7) using the 3-(4,5-dimethylthiazolyl)-2,5-diphenyl-tetrazolium bromide (MTT) method. The results showed a reasonable antiproliferative role played by the extract, indicating that this plant can be regarded as a suitable candidate for designing anticancer pharmaceutical preparations [ 172 ].…”

Section: Additional Bioactivities Of Cnmentioning

confidence: 99%

Calamintha nepeta (L.) Savi and its Main Essential Oil Constituent Pulegone: Biological Activities and Chemistry

Božović

Ragno

2017

Molecules

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Medicinal plants play an important role in the treatment of a wide range of diseases, even if their chemical constituents are not always completely recognized. Observations on their use and efficacy significantly contribute to the disclosure of their therapeutic properties. Calamintha nepeta (L.) Savi is an aromatic herb with a mint-oregano flavor, used in the Mediterranean areas as a traditional medicine. It has an extensive range of biological activities, including antimicrobial, antioxidant and anti-inflammatory, as well as anti-ulcer and insecticidal properties. This study aims to review the scientific findings and research reported to date on Calamintha nepeta (L.) Savi that prove many of the remarkable various biological actions, effects and some uses of this species as a source of bioactive natural compounds. On the other hand, pulegone, the major chemical constituent of Calamintha nepeta (L.) Savi essential oil, has been reported to exhibit numerous bioactivities in cells and animals. Thus, this integrated overview also surveys and interprets the present knowledge of chemistry and analysis of this oxygenated monoterpene, as well as its beneficial bioactivities. Areas for future research are suggested.

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“…Antioxidant enzymes activities namely, CAT, POD, and SOD were not tested earlier in selected wild medicinal taxa while few records reported earlier in other wild taxa like Rumex obtusifolius a wild medicinal plant and found to have a good antioxidant capacity [ 57 ]. Similarly, Calamintha officinalis also has potent antioxidants [ 58 ]. Alpha-amylase and esterase activities were higher in Z .…”

Section: Resultsmentioning

confidence: 99%

Biochemical profile and bioactive potential of thirteen wild folk medicinal plants from Balochistan, Pakistan

2020

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The recent focus is on the analysis of biological activities of extracts from thirteen folk medicinal plants from arid and semi-arid zones of Balochistan, Pakistan. Only a small proportion of them have been scientifically analyzed. Therefore the present investigation explores the biochemical and bioactive potential of different plant parts. Superoxide dismutase was detected maximum in Fagonia indica, (184.7±5.17 units/g), ascorbate peroxidase in Tribulus pentandrus (947.5±12.5 units/g), catalase and peroxidase were higher in Peganum harmala (555.0±5.0 and 2597.8±0.4 units/g, respectively). Maximum esterase and α-amylase activity was found in Zygophyllum fabago (14.3±0.44 and 140±18.8 mg/g, respectively). Flavonoid content was high in T. pentandrus (666.1±49 μg/ml). The highest total phenolic content and tannin was revealed in F. olivieri (72125±425 and 37050±1900 μM/g, respectively). The highest value of ascorbic acid was depicted in F. bruguieri (F.b.N) (448±1.5 μg/g). Total soluble proteins and reducing sugars were detected higher in P. harmala (372.3±54 and 5.9 ±0.1 mg/g, respectively). The maximum total antioxidant capacity was depicted in Tetraena simplex (16.9±0.01 μM/g). The highest value of lycopene and total carotenoids exhibited in T. terrestris (7.44±0.2 and 35.5±0.0 mg/g, respectively). Chlorophyll contents were found maximum in T. pentandrus var. pterophorus (549.1±9.9, 154.3±10, and 703.4±20.2 ug/g, respectively). All taxa exhibited anti-inflammatory activity and anti-diabetic potential. Z. eurypterum seeds exhibited the highest anti-inflammatory potential (96%), along with other taxa indicated (96-76%) activity when compared with the standard drug diclofenac sodium (79%). Seeds of T. pentandrus (85%) exhibited the highest anti-diabetic activity. The other taxa also exhibited inhibitory activity of α-amylase ranging from (85-69%) compared with Metformin (67%) standard drug. Phytochemical screening revealed that selected taxa proved to be the potential source of natural antioxidants and could further be explored for invivo studies and utilized in pharmaceutical industries as potent therapeutic agents validating their ethno-pharmacological uses.

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Antioxidant and Anti-Proliferative Activity of Calamintha officinalis Extract on Breast Cancer Cell Line MCF-7

Cited by 7 publications

References 13 publications

Potential Application of Some Lamiaceae Species in the Management of Diabetes

Potential Application of Some Lamiaceae Species in the Management of Diabetes

Calamintha nepeta (L.) Savi and its Main Essential Oil Constituent Pulegone: Biological Activities and Chemistry

Biochemical profile and bioactive potential of thirteen wild folk medicinal plants from Balochistan, Pakistan

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