Antioxidant and antibacterial properties of selected Thai weed extracts

Rattanata, Narintorn; Daduang, Sakda; Phaetchanla, Suthep; Bunyatratchata, Wandee; Promraksa, Bundit; Tavichakorntrakool, Ratree; Uthaiwat, Phangthip; Boonsiri, Patcharee; Daduang, Jureerut

doi:10.12980/apjtb.4.2014apjtb-2014-0422

Cited by 18 publications

(12 citation statements)

References 17 publications

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“…Further plant extract fractions were explored for their antimicrobial potential to confirm the traditional use of plant as an anti-infective agent (Rattanata et al, 2014;Silva et al, 2015). Previous report shows that A. vaginalis could have antibacterial properties (Narintorn et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical characterization, anti-cancer and antimicrobial activity of isolated fractions of Alysicarpus vaginalis

Tapadiya¹,

Kale

Saboo

2017

Bangladesh J Pharmacol

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The methanolic extract of Alysicarpus vaginalis was selected for fractionation due to its known reported biological activity. The four fractions were separated and subjected for in vitro antimitotic and anti-proliferative assays along with anti-cancer activity on two human cancers cell lines (SK-MEL-2 and Hep-G2). The antimicrobial potential of fractions had been evaluated against bacteria and fungi. From all fractions, acetone and n-butanol fractions were effective against the cell lines. They show strong inhibitory action with mitotic index 6.2 and 8.4 mg/mL and IC50 values of anti-proliferative assay in between 19.7 to 14.2 mg/mL respectively, which was found to be comparable to the standard methothrexate 5.9 mg/mL and 13.2 mg/mL respectively. In antimicrobial activity, the zone of inhibition had been observed in the range of 12-27 mm and MIC value was found in the range of 0.2-0.1 mg/mL. The acetone fraction was found to be most active against fungi, and E. coli whereas chloroform and n-butanol fractions were more effective against S. aureus and B. subtilis. The phytochemical characterization by HPLC analysis indicated the presence of important polyphenolic and steroidal compounds.

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Section: Discussionmentioning

confidence: 99%

Phytochemical characterization, anti-cancer and antimicrobial activity of isolated fractions of Alysicarpus vaginalis

Tapadiya¹,

Kale

Saboo

2017

Bangladesh J Pharmacol

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“…Preliminary phytochemical screening of ethanolic extract of A. vaginalis reported the presence of polyphenol [5]. The total phenolic content, total flavonoid content and antioxidant activity of the ethanolic extracts of the plant was evaluated [21]. The free radical scavenging activity and reducing power showed that the plant has significant antioxidant status.…”

Section: Discussionmentioning

confidence: 99%

“…The free radical scavenging activity and reducing power showed that the plant has significant antioxidant status. The presence of these phytochemicals reveals that the plant will possess various pharmacological activities like anti-inflammatory, anticancer, estrogenic gonadotropic, hepatoprotective functions [21].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening, Antimicrobial Activity and Brine Shrimp Lethality Bioassay of Different Extracts of Alysicarpus Vaginalis Var. Nummularifolius (Dc.) Miq. (Family: Fabaceae)

Kurian¹,

Josekumar²

2016

Int J Pharm Pharm Sci

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Objective: To evaluate the antimicrobial activity and cytotoxicity of hexane, ethyl acetate and methanol extracts of Alysicarpus vaginalis var. nummularifolius (DC) along with phytochemical analysis. Methods:The crude extract of hexane (AVH), ethyl acetate (AVE) and methanol (AVM) of Alysicarpus vaginalis var. nummularifolius (DC) were prepared and analysed for phytochemical constituents using standard methods. The cytotoxicity activity of the plant extracts was predicted using brine shrimp lethality assay (BSLA). The antimicrobial activity and the minimal inhibitory concentration (MIC) of the plant extracts were examined against 5 bacterial and 2 fungal strains using agar well diffusion method, and two fold serial dilution method, respectively. Results:The phytochemical screening studies showed a higher concentration of saponins, alkaloids, flavonoids, phenols, quinones and terpenoids in AVM than the other two extracts. The LC50 value of AVH and AVE were found to be 900.05 µg/ml and 754.35 µg/ml respectively using BSLA while that of AVM was>1000 ug/ml. All the extracts of the plant showed antimicrobial activity against most of the test organisms. The MIC values of AVM were lower than AVE for all the microbial strains except for Pseudomonas aeroginosa where AVE (107.87µg/ml) exhibited higher value than AVM (51µg/ml). Conclusion:The present study concluded AVM with a high presence of phytochemicals. The AVE and AVM were found to possess promising antimicrobial activity when compared with the standards. The AVM exhibited lesser toxicity when compared with AVH and AVE.

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“…The literature revealed that the presence of secondary metabolites including alkaloids, terpenoids, flavonoids in plants are responsible for its potential antibacterial activity [31]. On correlating the results an inference can be drawn that presence of majority of phytochemicals and good quality of phenolic compounds in ethyl acetate extract may be responsible for its prominent activity against all the bacterial strain.…”

Section: Discussionmentioning

confidence: 97%

“…Different plants extract exhibit efficient antioxidant properties due to their phytoconstituents, including phenolic compound [31]. Hydrogen donating abilities of phenolic compounds for DPPH radical were found in same ratio to the number of hydroxyl group and the amount of inactivated DPPH radical directly related to the antioxidant capability of the plant extracts [32].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Screening and Pharmacological Evaluation of Different Extracts of Plant Casearia Tomentosa Leaves

Tyagi

Shukla

2017

Int J Pharm Pharm Sci

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Objective: In present study different extracts of the leaves of plant Casearia tomentosa was investigated for the phytochemical screening, total phenolic content and various pharmacological activities like antioxidant, antidiabetic, antibacterial.Methods: Leaves of C. tomentosa were successively extracted by soxhlet extraction method using petroleum ether, chloroform, ethyl acetate and ethanol. The preliminary phytochemical investigation of different extracts was carried out according to standard methods. Antioxidant activity evaluated by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay and ferric reducing antioxidant potential (FRAP) method. Total phenolic content was evaluated by Folin-ciocalteau method. Antidiabetic activity estimated by α-amylase and α-glucosidase inhibitory assay while antibacterial activity was performed by disk diffusion method. Conclusion:The present study suggests that Casearia tomentosa leaves can be used as a potential source of natural antioxidant and natural antidiabetic, antibacterial agents.

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Antioxidant and antibacterial properties of selected Thai weed extracts

Cited by 18 publications

References 17 publications

Phytochemical characterization, anti-cancer and antimicrobial activity of isolated fractions of <i>Alysicarpus vaginalis</i>

Phytochemical characterization, anti-cancer and antimicrobial activity of isolated fractions of <i>Alysicarpus vaginalis</i>

Phytochemical Screening, Antimicrobial Activity and Brine Shrimp Lethality Bioassay of Different Extracts of Alysicarpus Vaginalis Var. Nummularifolius (Dc.) Miq. (Family: Fabaceae)

Phytochemical Screening and Pharmacological Evaluation of Different Extracts of Plant Casearia Tomentosa Leaves

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