Antioxidant and anticancer properties of berries

Abstract

The enduring relationship between dietary patterns and human health has led us to investigate the bioactive components present in fruits and vegetables for a very long time. Berries, notably the popular ones such as strawberry, raspberry, blueberry, blackberry, and the Indian gooseberry, are among the best known dietary sources due to the presence of a wide range of bioactive nutritive components. Bioactive components in berries include phenolic compounds, flavonoids, and tannins apart from vitamins, minerals, sugars, and fibers. Individually or synergistically, these have been shown to provide protection against several disorders. Mounting evidence suggests that consumption of berries confer antioxidant and anticancer protection to humans and animals. Free radical scavenging, protection from DNA damage, induction of apoptosis, and inhibition of growth and proliferation of cancer cells are just to name a few. This review comprehensively summarizes the key phytochemicals present in berries and their biological action in preventing oxidative stress and carcinogenesis.

Antioxidant and Antiproliferative Activities of Cyanidin‐3‐O‐Glucoside (C3G) Liposome in Caco‐2 Cells Cultivated in 2D and 3D Cell Culture Models

“…C3G is a potent antioxidant that displays anticancer properties in vitro and in vivo (Baby, Antony, & Vijayan, ; Liang et al., ; Zhou, Wang, Zhang, & Zhao, ), the health benefits, such as antioxidant properties, cardioprotective capacity, http://anti-inflammatory attract researchers’ eyes in many reports (Jiang et al., ; Li et al., ; Meng et al., ). The results of this study revealed that C3G and C3G liposomes can enhance the activity of GSH, SOD, and T‐AOC and decrease the MDA content after the H 2 O 2 treatment in Caco‐2 cells in certain concentrations in 2D and 3D cell culture models.…”

Berry Supplementation and Their Beneficial Effects on Some Central Nervous System Disorders

“…Even though the composition and the content of these compounds are dependent on the plant species, production status, agricultural processing, and storage, berries are an excellent source of polyphenols, flavonoids, and anthocyanins [20,21], which have been related to their potential beneficial effects on health.…”

“…Polyphenols or phenolic compounds are phytochemicals that result from the secondary metabolism of plants coming from the metabolic pathway of shikimic acid and acetate-malonate. They are composed of various chemical structures characterized by an aromatic nucleus of benzene substituted by a hydroxyl group called phenol [21]. Differences between subclasses are given by the number of phenolic rings and the elements attached to them, thus creating several families of compounds, such as flavonoids, anthocyanins, flavones, tannins, and coumarins, among others [21,[27][28][29].…”

“…In addition, they display antioxidant capabilities, such as decreasing free radicals and stress signals controlling calcium homeostasis in the brain [80,81], as well as the presence of hydrogen peroxide (H 2 O 2 ) and radicals peroxide (ROO) and superoxide (O2) [82,83]. They also exert protective effects against oxidative stress in cellular models of PD [84] and promote optimal neurotransmission, primarily in advanced age [21].…”

Myricetin and Hesperidin Inhibit Cerebral Thrombogenesis and Atherogenesis in <i>Apoe<sup>-/-</sup></i> and <i>Ldlr<sup>-/-</sup></i> Mice

“…They exert multiple biological effects, including antioxidant activity [1] [2], anti-inflammatory [3] [4], anti-cancer [5] [6] and neuroprotective properties [7]. Lipid oxidation has been recognized as the major source of deteriorative changes in the nutritional properties of fats and oils, and the anti-oxidative effects of flavonoids improve the stability of lipid containing foods.…”