Antioxidant and anticholinesterase activities of eleven edible plants

Boğa, Mehmet; Hacıbekiroğlu, Işıl; Kolak, Ufuk

doi:10.3109/13880209.2010.517539

Cited by 46 publications

(19 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The acetylcholinesterase and butyrylcholinesterase inhibitory activities of the ethanol and water extracts of A. macrocheatum bulb and aerial parts were tested using slightly modified Ellman method (Boğa, Hacibekiroğlu, & Kolak, 2011).…”

Section: Anticholinesterase Activitymentioning

confidence: 99%

Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.

et al. 2019

View full text Add to dashboard Cite

The study was aimed to investigate the phenolic compounds of Allium macrochaetum by LC‐MS/MS, as well as the antioxidant, antialzheimer, and antimicrobial activities of the extracts, and determination of the essential oil and fatty acid compositions by GC‐MS. The results indicate that malic acid and t‐caffeic acid are the major compounds in the bulbs. The main components of fatty acids were found to be linolenic (40.72%), oleic (19.79%), and palmitic (18.45%) acids. The allyl disulfide (66.97%) was found as major compound in the essential oil. The ethanol extract of the bulbs exhibited stronger ABTS cation (IC50: 55.90 ± 1.08 µg/ml) and DPPH free (IC50: 204.43 ± 2.17 µg/ml) radical scavenging activities than the other extracts. The extract also showed moderate cupric reducing activity with 1.52 absorbance at 100 µg/ml concentration. Only the ethanol extract of the bulbs showed weak inhibition (23.34 ± 0.11%) against butrylcholinesterase enzyme at 200 µg/ml. Practical applications Allium macrochaetum is a wild and edible garlic species which grown in Turkey, Iran, Iraqi, and Syria. A. macrochaetum has been used by local people in Turkish folk medicine as an antibiotic, and for the treatment of alopecia. The health benefits and nutritional values of A. macrochaetum were clarified in the first time. Phenolic compounds of A. macrochaetum were detected by LC‐MS/MS. The essential oil and fatty acid compositions of A. macrochaetum were identified by GC‐MS. Antioxidant, antialzheimer, and antimicrobial activities potential of A. macrochaetum were determined.

show abstract

Section: Anticholinesterase Activitymentioning

confidence: 99%

Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Hence they strongly recommended the huperzine-A promising compound for the pharmacological use in dementia [2]. The ethanol extract of cinnamon exhibited 63.02% AChE inhibition [4]. The petroleum ether extract of Iris suaveolens indicated moderate anticholinesterase activity [5].…”

Section: Discussionmentioning

confidence: 99%

“…Recently many medicinal plants have been screened to know for their anti-cholinesterse property [3]. The extracts prepared from cinnamon [Cinnamomum cassia Presl (Lauraceae) [4], Iris suaveolens [5], Ficus carica [6], Tutin, (Umbelliferae), [7] and Datura stramonium [8] have shown anticholoinestrase potential. Alzheimer's disease is associated with impairment in cholinergic transmission.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Potential of Acephate and Ethanol Extract of Bacopa Monnieri on AChE in Rat Cortex and Hippocampus

Tembhre¹,

Ahirwar²,

Gour³

et al. 2015

IJBBB

View full text Add to dashboard Cite

Abstract:The objective of present study was to evaluate the in vivo effect of Bacopa monnieri leaf extract (100 mg/kg) and acephate (37.8 mg/kg) on Acetylcholinesterase (AChE) activity, kinetics and histology of cerebral cortex and hippocampus of brain of male albino rat. AChE activity was measured spectrophotometrically according to the method of Ellman et al.. The acephate inhibited AChE activity strongly in cerebral cortex (72.5%; P < 0.02) than in hippocampus (55.6%; P < 0.02). Bacopa monnieri similarly elicited higher AChE inhibition in cerebral cortex (51.6%; P < 0.05) than in hippocampus (38%; P < 0.01). However, synergistic inhibitory effect was recorded in rats pretreated with Bacopa monnieri followed by acephate exposure. Kinetic study of treated groups demonstrated competitive AChE inhibition in the brain regions, which was evident by increased Km and unchanged Vmax values against the control group. The histopathological examinations showed degeneration of pyramidal cells, deformity of neurocytes and vacuole formation in cytoplasm. These changes were pronounced with acephate. Our result shows that Bacopa monnieri has anti-cholinesterase potential hence it could provide novel pharmacological leads of potential benefit to the treatment of Alzheimer's disease and therefore warrant further investigation.

show abstract

“…Boga et al . [63] found the high amount of anticholinesterase activities from the dichloromethane, ethanol, and water extracts of spinach.…”

Section: Phytochemical Substancesmentioning

confidence: 99%

Review of neuro-nutrition used as anti-alzheimer plant, spinach Spinacia oleracea

Jiraungkoorskul¹

2016

Phcog Rev

View full text Add to dashboard Cite

Neuro-nutrition is the nutrition needed to achieve health brain and neurocognitive function. Diets rich in antioxidants, vitamins, flavonoids, and polyphenolic compounds will help suppress the onset of Alzheimer's disease. Spinacia oleracea (Family: Amaranthaceae) commonly known as spinach or Buai Leng (in Thai), one of the traditional medicinal plants with high in those mention nutrients. The micronutrients in spinach include a range of vitamins and minerals, which can prevent deficiency diseases and are essential for normal physiological function. Its phytochemicals are carotenoids, flavonoids, and phenolic compounds, which can prevent chronic health problems, as well as other diseases associated with aging. The objective of this article was to conduct a review on various ethnomedicinal uses of the spinach and its influences on the pathophysiology of Alzheimer's disease based on a literature review.

show abstract

Antioxidant and anticholinesterase activities of eleven edible plants

Abstract: This study indicated that the ethanol extract of cinnamon may be a new potential resource of natural antioxidant and anticholinesterase compounds.

Cited by 46 publications

References 21 publications

Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.

Comprehensive analysis of an uninvestigated wild edible medicinal garlic species from Turkey: Allium macrochaetum Boiss. & Hausskn.

Inhibitory Potential of Acephate and Ethanol Extract of Bacopa Monnieri on AChE in Rat Cortex and Hippocampus

Review of neuro-nutrition used as anti-alzheimer plant, spinach Spinacia oleracea

Contact Info

Product

Resources

About