Antioxidant and anticholinesterase effects of the ethanol extract, ethanol extract fractions and total alkaloids from the cultivated Ruta chalepensis

Gali, Lynda; Bedjou, Fatiha

doi:10.1016/j.sajb.2018.04.011

Cited by 59 publications

(50 citation statements)

References 44 publications

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“…However, in the water extracts, they were lower than three Centaurea species and Ganoderma adspersum [32,33]. In the ethanol extracts, they are comparable with pyrola leaves from some locations in Northeast China, but lower than Ruta chalepensis and olive leaves [26,34,35].…”

Section: Effects Of Solvent and Geographical Origin On Bioactive Metamentioning

confidence: 74%

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

Zhou

Chen

Lin

et al. 2019

Forests

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Cyclocarya paliurus (Batal.) Iljinskaja is an indigenous and multifunction tree species in China, but it is mainly used in pharmaceutical and nutraceutical ingredients. To make a comprehensive evaluation on its bioactive metabolites, antioxidant and antitumor potentials of C. paliurus leaves, the leaf samples were collected from 15 geographic locations (natural populations) throughout its distribution areas. High-performance liquid chromatography (HPLC) and colorimetric methods were used to detect the contents of bioactive metabolites. The antioxidant activity was evaluated by 2,2′-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and reducing power assays. The antiproliferative activity on different cancer cell types was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Contents of bioactive metabolites, and antioxidant and antiproliferative activities in the extracts were significantly affected by solvent and population. In most cases, the contents of flavonoids and triterpenoids, and the antioxidant and antiproliferative activities in the ethanol extracts were higher than the water extracts. The best scavenging capacity of DPPH (IC50 = 0.34 mg/mL) and ABTS (IC50 = 0.50 mg/mL) radical occurred in the ethanol extracts of S15 and S7 population respectively, while the strongest reducing power (EC50 = 0.71 mg/mL) was achieved in the ethanol extracts of S14 population. The antiproliferation effects of C. paliurus extracts on cancer cells varied with different cell types. The HeLa cell was the most sensitive to C. paliurus extracts, and their IC50 values of the ethanol extracts varied from 0.13 to 0.42 mg/mL among C. paliurus populations. Redundancy analysis showed that total polyphenol had the greatest contribution to the antioxidant activity, but total flavonoid was mostly responsible for the antiproliferation effects. These results would provide important scientific evidences not only for developing C. paliurus as a potent antioxidant and antitumor reagent, but also for obtaining the higher yield of bioactive compounds in the C. paliurus plantation.

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Section: Effects Of Solvent and Geographical Origin On Bioactive Metamentioning

confidence: 74%

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

Zhou

Chen

Lin

et al. 2019

Forests

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“…The reducing power of tested samples was performed according to Gali and Bedjou (2019), with minor modifications. 10 µL of sample was mixed with 40 μL of phosphate buffer 0.2 M (pH 6.6), 50 μL of 1 % K3Fe(CN)6 and then the plate was incubated at 50 °C for 20 min.…”

Section: Reducing Power Assaymentioning

confidence: 99%

Chemical profile, antioxidant and photoprotective activities of essential oil and crude extracts of Algerian Thymus serpyllum

Madouni

Meddah

Aicha

et al. 2021

Nova Biotechnol. Chim.

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Thymus serpyllum is an aromatic and medicinal plant widely used in Algerian folk medicine. It was collected from Mascara region North West of Algeria and studied in the aim to provide more knowledge about chemical composition, antioxidant and photo-protective activities of essential oil, ethanolic and infusion extracts. The chemical analysis of investigated T. serpyllum EO was performed for the first time in this research work. It was carried out by GC/MS for identifying 25 components where the dominated compounds were Carvacrol (66%) and γ–Terpinene (11.5%). The phenolic profile of ethanolic and aqueous infusion extracts was performed using HPLC chromatography and the data showed the Benzoic acid and Rosmarinc acid were found as major compounds. Extracts showed an excellent source of total phenols and flavonoids. Antioxidant activity was evaluated using DPPH, Galvinoxyl radical (GOR), CUPRAC, reducing power and O-phenanthroline approaches. All extracts showed a significant antioxidant capacity with different mechanisms. However, ethanol and infusion extracts showed stronger capacity than EO. Moreover, the photoprotective activity of T. serpyllum extracts was explored for the first time in our study. Extracts exhibited high values of sun protective factors (SFP) with 38.34±2.29 and 38.82±2.23 for ethanol and infusion extract respectively. Results of our study may encourage the pharmacologic, food and cosmetic sectors to use the wild thyme as natural and healthy source of active compounds.

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“…The n-hexane fraction has a higher percentage of antioxidant activity than ethyl acetate fraction because n-hexane fraction has lipophilic compounds. Based on the research by Gali and Bedjou (2019), BCB assay has high specificity toward lipophilic compounds as these compounds can participate to stabilize the free radical. In Table 2, the percentage value of antioxidant activity statistically showed methanol extract, ethyl acetate fraction, n-hexane fraction and dichloromethane fraction did not have significant difference.…”

Section: Bcbmentioning

confidence: 99%

Baccaurea racemosa (Reinw. ex Blume) Müll. Arg. pulp: a potential natural antioxidant

Permatasari¹,

Riyanto²,

Rohman³

2019

Food Res.

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Baccaurea racemosa (Reinw. ex Blume) Müll. Arg. is a fruit widely grown in Indonesia locally known as ‘kepundung’. Some of genus Baccaurea has potential to be developed as a natural antioxidant. However, the antioxidant activity of B. racemosa pulp has not been published. This study is aimed to (i) explore the antioxidant activity, (ii) measure the total phenolic and flavonoid contents, and (iii) investigate the correlation of antioxidant activity of extract and fractions of B. racemosa pulp with their total phenolic and flavonoid contents. Fresh B. racemosa pulp was macerated with methanol to obtained methanolic extract. The methanolic extract was partitioned using n-hexane followed dichloromethane and ethyl acetate. This study revealed that ethyl acetate fraction has the highest antioxidant activity with the scavenging activity of free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-Azinobis(3-etylbenzthiazoline)-6-sulfonic acid (ABTS) with values IC50 127.155±4.311ug/mL and 108.155±6.455 mM trolox equivalent/100 mg dry extract respectively. However, the highest antioxidant activity using β-carotene bleaching (BCB) assay is the methanolic extract with value 36.898±13.240%. Furthermore, the ethyl acetate fraction has the highest total phenolic content (TPC) and total flavonoid content (TFC) with values 42.975±1.978 mg gallic acid equivalent/g dry extract (mg GAE g-1 dry extract) and 122.813±1.604 mg rutin equivalent/g dry extract (mg RE g-1 dry extract) respectively. TPC and TFC of B. racemosa pulp have a significant correlation with ABTS free radical scavenging activity. In this current study, it was discovered that ethyl acetate fraction of B. racemosa pulp can be developed to be a natural antioxidant.

show abstract

Antioxidant and anticholinesterase effects of the ethanol extract, ethanol extract fractions and total alkaloids from the cultivated Ruta chalepensis

Cited by 59 publications

References 44 publications

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

A Comprehensive Assessment of Bioactive Metabolites, Antioxidant and Antiproliferative Activities of Cyclocarya paliurus (Batal.) Iljinskaja Leaves

Chemical profile, antioxidant and photoprotective activities of essential oil and crude extracts of Algerian Thymus serpyllum

Baccaurea racemosa (Reinw. ex Blume) Müll. Arg. pulp: a potential natural antioxidant

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