Antioxidant and antihyperglycemic activities of Scorzonera cinerea radical leaves in streptozocin-induced diabetic rats

Abstract

Scorzonera species are used for treating various diseases. They are consumed raw, especially in the spring, and have nutritious and dietetic values. This study evaluated the antidiabetic and antioxidant effects of ethanolic extracts of Scorzonera cinerea (Sc) radical leaves in diabetes mellitus. Five random groups of Wistar rats (n = 8) were created – control, diabetic, acarbose, Sc-Dried, and Sc-Frozen. Phenolic profiles of extracts were determined by HPLC. Free radical scavenging capacity was measured using DPPH and ABTS tests. The inhibitory effects of Sc extracts on α-glucosidase and α-amylase activities were also evaluated. Moreover, superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities, glutathione (GSH) concentration, malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS) were analyzed in the liver tissues. While dried Scorzonera extract was more effective in α-amylase inhibitory activity, frozen Scorzonera extract was more effective in α-glucosidase inhibitory activity. Sc-Dried and Sc-Frozen extracts lowered blood glucose and HbA1c levels, they also increased insulin. Although liver MDA and TOS were significantly increased in the diabetic group, their values were significantly lower in the Sc-Dried- and Sc-Frozen-treated groups. GSH, TAS, and anti-oxidant enzyme activities decreased in the diabetic group, but Sc-Dried and Sc-Frozen supplements significantly enhanced liver antioxidant values. In conclusion, S. cinerea treatment exerts potential hypoglycemic and antioxidant effects in diabetes. Thus, it can be considered as a candidate dietary supplement for health benefits in diabetes.

Investigation of Phenolic Composition, Antioxidant Capacity, and Antidiabetic Effect of Ornithogalum lanceolatum L.: An in vitro Study

“…These mechanisms may be through inhibition of digestive enzymes and/or by acting like insulin-mimetic to reduce postprandial blood glucose (Temiz & Temur, 2019). Besides they might have antidiabetic effects such as reducing glucose absorption in the small intestine, stimulation of insulin secretion from islets, improving insulin sensibility, and increasing the uptake and bioavailability of glucose to the cells (Temiz and Temur, 2019;Temiz, 2021;Yang et al, 2015;Zhang et al, 2020). Backgrounds of these mechanisms have complex pathways in the cells.…”

“…Recently, medicinal and wild edible plants have gained attention as they offer both an important source of food and natural remedies for various ailments (Milella et al, 2014). They also have nutritive and dietetic value, largely owing to the presence of complex carbohydrates, mineral salts, vitamins, and polyphenolic compounds (Sekeroglu et al, 2006;Temiz, 2021). Turkey is one of the countries that have rich flora in terms of medicinal, aromatic, and wild edible plants.…”

Glinus lotoides linn. Seed extract as antidiabetic agent: In vitro and in vivo anti-glucolipotoxicity efficacy in Type-II diabetes mellitus

“…Furthermore, it is equipped with hepatoprotective [ 21 ], gastroprotective [ 66 ], wound healing (epithelization or cell regeneration) [ 15 ], free radical scavenging, and antioxidative [ 21 ] features. Oxidative stress has been tied to the genesis of DM and its consequences [ 67 ]. Ultimately, the probable way by which G. lotoides brings about its antidiabetic effect may be by ameliorating insulin resistance and insufficiency through increasing pancreatic β-cell regeneration and attenuating β-cell slaying caused by chronic hyperglycaemia induced oxidant burden.…”

Evaluation of Antidiabetic Activities of Scorzonera Species on Alloxan Induced Diabetic Mice

“…It is a well-known fact that Scorzonera species are beneficial in many medical indications such as, common cold (such as mucolytic, diuretic and antipyretic), wound healing and against acute hepatotoxicity, arteriosclerosis, kidney diseases, hypertension, diabetes mellitus, rheumatism, pain (7,12,22,23). Studies related to Turkish folk medicine have mentioned that many of the Scorzonera species have antidiabetic properties (7,13) and a single recent study has been reported S. cinerea radical leaves have an antidiabetic effect by inhibiting α-amylase and α-glucosidase and increasing the insulin level in diabetic rats (24). Although all that background a study that examines the antidiabetic properties, with an up-to-date method, of many Scorzonera species was not found.…”

“…From the chemical point of view, the Scorzonera species have been subjected to intensive studies which have led to the isolation of several types of compounds. Previously, a number of compounds such as dihydroisocoumarines, bibenzyl derivatives, flavonoids, lignans, stilbene derivatives, quinic and caffeic acid derivatives, sesquiterpene, sesquiterpene lactones and triterpenes have been isolated from the Scorzonera species and many of the isolated compounds have been identified as new structures(8)(9)(10)12,(22)(23)(24)32,33). In current study none of the investigated Scorzonera species aerial parts except S. cana var.…”