Antioxidant and Antimelanogenic Behaviors of Paeonia suffruticosa

Abstract

Antioxidant properties of eight Paeonia suffruticosa (Ps) extracts (Ps-1 to Ps-8) were evaluated. The respective half maximally effective concentration (EC(50)) values of Ps-1 ~ 8 were 10.0, 9.8, 63.6, >100, 3.8, 85.1, 6.9, and 0.7 μg/ml for 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·) radical scavenging efficiency and 22.9, 11.4, 53.1, >100, 7.5, 97.6, 43.7, 4.2 μg/ml for 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS·(+)) radical scavenging capacity. The Ps-8 exhibited high free radical scavenging capacity, ion-chelating ability, reducing power, and inhibition of lipid peroxidation, which may have been attributable to its abundant phenolic and flavonoid content. In Hs68 and B16 cells treated with 100 μg/ml Ps-1, Ps-3, Ps-4 and Ps-6, expressions of toxic activities were lower than those in cells treated with arbutin and ascorbic acid. The antimelanogenesis properties were also tested in B16 cells. Extract Ps-1, and particularly extract Ps-6, considerably inhibited cellular tyrosinase and 3,4-dihydroxyphenylalanine (DOPA) oxidase activity and also reduced melanin content in B16 cells by down-expression of melanocortin-1 receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related proteins-1 (TRP-1). The results suggest that P. suffruticosa extracts have antioxidant and antimelanogenesis activities with potential applications in cosmetic materials or food additives.

Anti-inflammatory and Anti-oxidative Activities of Paeonol and Its Metabolites Through Blocking MAPK/ERK/p38 Signaling Pathway

“…It has several uses such as analgesic, anti-pyretic, anti-allergic, and antiinflammatory applications and also has a beneficial effect in the prevention and treatment of thromboembolic diseases [1][2][3][4]. Paeonol (2'-hydroxy-4'-methoxyacetophenone), the main active component of Cortex Moutan, has been reported to inhibit platelet aggregation, thromboxane A2 [5], and free radical formation [6]. Paeonol is used as a food additive and in traditional oriental medicines in treating various diseases including inflammatory diseases and atherosclerosis [7].…”

Supercritical fluid extract of Lycium chinense Miller root inhibition of melanin production and its potential mechanisms of action

“…In addition, the root extract also shows antioxidant capacities, which fits the trend of skin anti-hyperpigmentation agents that show dual functions in anitimelanogenesis and antioxidation. Recently, several plants such as Paeonia suffruticosa [41] and chestnut flower extract [42] have also been reported to show antioxidant and antimelanogenic properties similar to those of Lycium chinense Miller root SFE. The results suggest that Lycium chinense Miller root SFE decreased melanin production due to its depletion of cellular ROS.…”

Favorable Control Effects of Palmijihwang-Whan on the Propylthiouracil Induced Hypothyroidism Related Rat Male Reproductive Organ Damages

“…, 茯苓 19) , 澤瀉 20) , 牧丹皮 21) , 肉桂 22) 및 附子 306.00 g) as intact vehicle control, PTU control, LT4, PMJHW 500, 250 and 125 mg/kg treated groups. PMJHW were administered, once day for 42 days from 2 weeks before start of PTU treatment as an oral dose of 500, 250 and 125 mg/kg (body weight), and hypothyroidism was induced by daily subcutaneous treatment of PTU 10 mg/kg for 28 days.…”