Antioxidant and Antiproliferative Activities of the Essential Oils from<i>Thymbra capitata</i>and<i>Thymus</i>Species Grown in Portugal

Miguel, Maria Graça; Gago, Custódia; Antunes, Maria Dulce; Megı́as, Cristina; Cortés-Giraldo, Isabel; Vioque, Javier; Lima, A. Sofia; Figueiredo, A. Cristina

doi:10.1155/2015/851721

Cited by 30 publications

(28 citation statements)

References 20 publications

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“…caespititius and Th. mastichina EOs in the present work (assay performed in the presence of cyclodextrins), the values for which are almost tenfold higher than those reported [9], in which cyclodextrins were not introduced in the method. For the first time, the antioxidant activity of Th.…”

Section: Ricontrasting

confidence: 71%

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Antioxidant, Anti-inflammatory and Anti-hyperglycaemic Activities of Essential Oils from Thymbra capitata, Thymus albicans, Thymus caespititius, Thymus carnosus, Thymus lotocephalus and Thymus mastichina from Portugal

Aazza

El-Guendouz

Miguel

et al. 2016

Natural Product Communications

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The in vitro antioxidant, anti-inflammatory, anti-hyperglycaemic, and anti-acetylcholinesterase activities of the essential oils (EOs) isolated from six Lamiaceae species (Thymbra capitata, Thymus albicans, Th. caespititius, Th. carnosus, Th. lotocephalus and Th. mastichina) grown in Portugal, were evaluated. Th. caespititius and T. capitata carvacrol/thymol-rich EOs showed the best capacity for preventing lipid peroxidation, and scavenging the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and peroxyl free radicals, as well as for inhibiting lipoxygenase and α-amylase. However, Th. caespititius and Th. lotocephalus 1,8-cineole and linalool rich EOs were the best inhibitors of α-glucosidase. T. capitata, Th. lotocephalus and Th. albicans EOs were the most active for inhibiting acetylcholinesterase. Th. caespititius and Th. mastichina EOs were the main scavengers of nitric oxide (NO) radicals. The comparison between the present data with a survey of the existing literature on the in vitro biological activities of the essential oils isolated from the same species from Portuguese origin, using other methodologies, showed some differences. For instance the use of two oxidizable substrates (egg yolk and lecithin liposomes) led to distinct results mainly for those samples with relatively low activity. In addition, the EOs capacity for scavenging peroxyl radicals was also influenced by the presence of cyclodextrins, as a synergism seemed to occur between EOs and those carbohydrates.

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Section: Ricontrasting

confidence: 71%

“…Such a difference cannot only be attributed to carvacrol or thymol, since when separately assayed, they showed similar activities [11]. Miguel et al [9] found that different percentages of carvacrol in diverse Th. caespititius EOs or T. capitata EO could present similar antioxidant activity.…”

Section: Rimentioning

confidence: 99%

Antioxidant, Anti-inflammatory and Anti-hyperglycaemic Activities of Essential Oils from Thymbra capitata, Thymus albicans, Thymus caespititius, Thymus carnosus, Thymus lotocephalus and Thymus mastichina from Portugal

Aazza

El-Guendouz

Miguel

et al. 2016

Natural Product Communications

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“…The standard curve was obtained by plotting Trolox concentrations against the average net AUC of the measurements for each concentration. Final ORAC values were calculated using the regression equation between Trolox concentration and the net AUC and were expressed as µmol TE/g EO [ 24 ]. Tests were carried out in triplicate.…”

Section: Methodsmentioning

confidence: 99%

Antibacterial, Antioxidant, and Antiproliferative Activities of Corymbia citriodora and the Essential Oils of Eight Eucalyptus Species

et al. 2018

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Background: Essential oils (EOs) have shown antimicrobial, antioxidant, and antiproliferative activity, which may, alone or in combination with other substances, potentially be used for the development of new drugs. However, their chemical variability, depending on the species, varieties, or geographical origin (among other factors) determines different bioactivities that need to be evaluated. Methods: The antioxidant activity of Corymbia citriodora and eight Eucalyptus species EOs was determined using two different methods: the scavenging ability of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS+•) and peroxyl free radicals or oxygen radical absorbance capacity (ORAC). Antibacterial activity was evaluated using the microorganisms Streptococcus pneumoniae (strains D39 and TIGR4), and Haemophilus influenza (strain DSM 9999). The essential oils’ minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) was assessed using a microdilution method. The antiproliferative activity was determined using the THP-1 cell line (human acute monocytic leukaemia) with methylthiazolyldiphenyl-tetrazolium bromide assay (MTT). Results: Corymbia citriodora and Eucalyptus viminalis EOs showed the highest ABTS and peroxyl free radical scavenging capacity. Eucalyptus globulus EO showed a high potential to treat Streptococcus pneumoniae infections. Haemophilus influenzae was the respiratory pathogen that showed the highest resistance to all EOs, including tea tree EO. After 96 h of incubation, at 25 μg/mL, Eucalyptus radiata and Eucalyptus viminalis EOs showed highest cytotoxic activity against the THP-1 cell line. Conclusions: Despite their specific bioactivities, no single EO showed simultaneously good antioxidant, antimicrobial, and antiproliferative activity.

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“…It has been observed that the EO of T. capitata shows a potent antioxidant activity due to its high content of phenols (thymol or carvacrol) [37]. This statement is supported by Aazza et al [38], when compared with the antioxidant activity of several thyme species.…”

Section: Bioactivity Of T Capitata Eo 41 Antioxidant Activitymentioning

confidence: 78%

“…In addition, this toxicity can be used as antiproliferative activity in in vitro experiments, since the EO extracted from fruits of T. capitata inhibited the growth of cells isolated from cervical cancer (HeLa). Likewise, the EO extracted from flowers and fruits of this species inhibited the growth of histiocytosis cells (U937) [30] and tumor cells responsible for acute monocytic leukemia (THP-1) [37].…”

Section: Bioactivity Of T Capitata Eo 41 Antioxidant Activitymentioning

confidence: 97%

Essential Oils of Thymbra capitata and Thymus hyemalis and Their Uses Based on Their Bioactivity

Sabater-Jara¹,

Funes²,

Pedreño³

et al. 2020

Thymus

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Essential oils (EO) are volatile compounds produced by the secondary metabolism of aromatic plants. They are complex mixtures whose main compo nents are synthesized by the mevalonic acid and the methyl erythritol phosphate pathways, which lead to the biosynthesis of terpenes, and the shikimic acid pathway, responsible for the biosynthesis of phen ylpropanoid compounds. In nature, EOs are stored in the aerial parts of the plant, being of vital importance for their survival due to their antimicrobial properties. In addition, EOs provide protection against herbivores to the aromatic plants and allow them to repel or attract insects because of their strong fragrance, as well as compete with other plants of the same environment. Humans have exploited the properties of their EOs since ancient times, being used as medicinal remedies, among other uses. Currently, aromatic plants are used in pharmaceutical and food industries. One of the most commonly used aromatic plants is thyme. Thyme is a perennial aromatic plant, taxonomically belonging to the genera Thymus and Thymbra, belonging to the family Lamiaceae. These plants are very abundant in the Mediterranean Region. In this review, we focus on the study of the properties and use of EOs of Thymbra capitata (L) Cav. and Thymus hyemalis Lange., whose EOs are rich in phenolic monoterpenes. These compounds are responsible for their antioxidant, anti-inflammatory, anticarcinogenic, antibacterial, antifungal, and antiparasitic properties.

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Antioxidant and Antiproliferative Activities of the Essential Oils fromThymbra capitataandThymusSpecies Grown in Portugal

Cited by 30 publications

References 20 publications

Antioxidant, Anti-inflammatory and Anti-hyperglycaemic Activities of Essential Oils from Thymbra capitata, Thymus albicans, Thymus caespititius, Thymus carnosus, Thymus lotocephalus and Thymus mastichina from Portugal

Antioxidant, Anti-inflammatory and Anti-hyperglycaemic Activities of Essential Oils from Thymbra capitata, Thymus albicans, Thymus caespititius, Thymus carnosus, Thymus lotocephalus and Thymus mastichina from Portugal

Antibacterial, Antioxidant, and Antiproliferative Activities of Corymbia citriodora and the Essential Oils of Eight Eucalyptus Species

Essential Oils of Thymbra capitata and Thymus hyemalis and Their Uses Based on Their Bioactivity

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