Antioxidant and Antiproliferative Activity of Diospyros lotus L. Extract and Isolated Compounds

Loizzo, Monica Rosa; Said, Ataa; Tundis, Rosa; Hawas, Usama W.; Rashed, Khaled; Frega, Natale G.; Menichini, Francesco

doi:10.1007/s11130-009-0133-0

Cited by 108 publications

(73 citation statements)

References 29 publications

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“…As A549 line has been widely used as a model system to study human alveolar carcinoma, cytotoxic profile of flavonoids in these cells was previously characterized with the results very similar to those measured in our work. Indeed, the IC 50 value of 72.2 µM for quercetin is close to the inhibitory constants published by Loizzo et al (26), Tan et al (27)(28)(29), Robaszkiewicz et al (30), and Chan et al (31); and IC 50 values more than 100 µM were previously reported for fisetin (32), hesperetin (33-35), luteolin (32,36), chrysin (35), baicalein (34), daidzein (37), and genistein (38). Based on our results presented in this article, cytotoxic activity profiles of flavonoids were rather similar for both A549 and HCC-44 lung cancer lines, despite the gender difference of initial origin of these cells.…”

Section: Discussionsupporting

confidence: 88%

Cytotoxic action of methylquercetins in human lung adenocarcinoma cells

et al. 2017

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Abstract. Lung cancer is the malignant disorder associated with a high number of fatalities in women and men worldwide. Despite continuous improvements in diagnostic strategies and therapeutic modalities over the past decades, the prognosis and survival rate of patients suffering from lung cancer are still unsatisfactory and suggest the requirement for further molecular studies with different lung cancer models. In the present study, the anticancer action of two methylated metabolites of quercetin, isorhamnetin and tamarixetin, was assessed by studying their antiproliferative and apoptosis-inducing potential in human lung adenocarcinoma cell lines, A549 and HCC-44. Both methylquercetins decreased the viability of lung cancer cells at doses significantly lower than those effective for parent quercetin. The IC 50 values measured for isorhamnetin were 26.6 and 15.9 µM in A549 and HCC-44 cells, respectively. For tamarixetin, the IC 50 values were 19.6 and 20.3 µM in A549 and HCC-44 cells, respectively. These results were many-fold lower than the respective values for quercetin (72.2 and 107.6 µM for A549 and HCC-44 cells, respectively). Based on the activation of caspase family members, both metabolites induced apoptotic cell death in the tested cell lines, predominantly via the extrinsic pathway in A549 cells and in both intrinsic and extrinsic pathways in HCC-44 cells. As A549 and HCC-44 lines were originally established from a male and female patient, current data may suggst some gender differences in the action of quercetin derivatives. Addition of a methyl group in the 3'-or 4'-position of the B-ring of quercetin significantly increased the anticancer activity of this flavonol towards lung adenocarcinoma cells, which demonstrated that these compounds may be considered as potential novel candidates for the development of future chemotherapeutics in the fight against lung cancer.

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Section: Discussionsupporting

confidence: 88%

Cytotoxic action of methylquercetins in human lung adenocarcinoma cells

et al. 2017

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“…The data obtained demonstrate a considerable impact of polyphenols on the anticancer activity of the extracts (particularly ethanolic ones). Numerous studies have reported on the antiproliferative activity of flavonoids and tannins [30]. A high cytotoxic activity of According to the data presented in Tables 2 and 4, the antibacterial properties of rose galenic preparations against most of the bacterial strains studied were strongly influenced by flavonoids, except for tinctures where the presence of o-dihydroxyphenols was correlated with antipseudomonal potential.…”

Section: Correlation Between Antiradical Anticancer and Antibacteriamentioning

confidence: 96%

“…Many studies were undertaken to show the influence of phenolic and carotenoid components on the biological activity of plant extracts [24,30]. Likewise, our study was to define the relationship between the biological activity and chemical composition of the extracts.…”

Section: Correlation Between Antiradical Anticancer and Antibacteriamentioning

confidence: 99%

“…caffeic acid) and hydrolysable tannins in various R. rugosa parts [1,8,12,32]. These compounds possess proven cytotoxic, antimicrobial and antioxidant activity [8,12,30]. Taking into consideration the types of extraction used in our study, these compounds should also be present in the tested samples.…”

Section: Correlation Between Antiradical Anticancer and Antibacteriamentioning

confidence: 99%

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Biological activity and composition of teas and tinctures prepared from Rosa rugosa Thunb.

et al. 2011

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Biological activity and composition of teas and tinctures prepared from Rosa rugosa Thunb. IntroductionRugosa rose (Rosa rugosa Thunb.) is an Asian indigenous plant with a long record of traditional medicinal use. Since its introduction to Europe, the hips and flowers of rugosa rose and its hybrids have been widely available and used for production of teas, wines, juices and jams [1,2]. Rose hips are rich in many vitamins, which have prompted their use in medicine, particularly for conditions accompanied by immune deficiency, e.g. common cold [3]. Despite the great commercial potential of the R. rugosa, only a few reports have been published about the phytochemical content and biological activity of this plant; in particular, the knowledge of its roots and leaves remains limited, which is surprising considering that rose roots have been utilized by Asian folk medicine to treat conditions such as diabetes mellitus, pain and chronic inflammatory diseases [4].Previous research has revealed the presence of many biologically active compounds in all parts of R. rugosa [1,[4][5][6][7]. Many of them act as potential natural antioxidants [8][9][10]. Although some R. rugosa extracts were reported to possess antioxidant properties [5,11], there are no detailed studies on their antiradical potential. Similarly, there are only a few data on antibacterial and antitumor properties of the plant. Petals have been shown to have selective antibacterial activity against intestinal and pathogenic bacteria [12]. In terms of antitumor activity, Lee et al. [13] demonstrated that methanolic extracts from rose stem acted as anti-prostate cancer agents. The antiproliferative activity of juice from R. rugosa fruit on several cancer cell lines was indicated as well [14]. However, there are no precise data about phenolic content in different parts of this plant. Research on the composition and activity of other rose species may suggest that in this respect rugosa rose is also of great importance and potential [3].

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“…3,4,7]. 최근의 고욤나무 열매 추출물에서 진정작용, 항당뇨, 항암, 항균효능, 항산화효능, 용혈작용, 신경보호 능이 세포 및 동물실험을 통해 확인되었다 [5,12,18,20,28]. 고욤 잎 추출 물에서는 항알러지 및 항가렴움증 및 항산화, 항염증, 간보호 능에 대한 효능이 보고되었다 [17,22,24].…”

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Anti-oxidant and α-Glucosidase Inhibition Activity of Extracts or Fractions from Diospyros lotus L. Leaves and Quantitative Analysis of Their Flavonoid Compounds

Kim¹,

Kim²,

Kim³

et al. 2014

Journal of Life Science

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Persimmon leaves were commonly consumed as beverages, but were also used as popular folk medicine in Asia. The purpose of this work was to assess the biological activities of Diospyros Lotus L. extracts (DLLE). Various solvent extracts, including n-Hexnae, CHCl3, EtOAc, and n-BuOH fractions, were obtained from the methanol extract of Diospyros Lotus L. leaves. The increasing interest in the powerful biological activity of plant phenolics and flavonoids outlined the necessity for determining their content in medicinal herbs. In this study, the total polyphenol and flavonoid contents (TPC and TFC) in the EA fraction were higher than those of other fractions. The biological activities of DLLE were tested using the 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging activity assay, as well as superoxide dismutase (SOD) activity as an anti-oxidant effect and α-glucosidase inhibitory activity as an anti-diabetic effect. The EA fraction with high TPC and TFC values showed the highest anti-oxidant effect and high α-glucosidase inhibition. The EA fractions were further purified into eight fractions using open column chromatography. Higher anti-oxidant and anti-α-glucosidase activity were observed in polar fractions. The content of the flavonoids, including quercein-3-O-rutinoside, kaempferol-3-O-glucoside, myricetin, luteolin, and kaempferol, were analyzed in effective fractions using high-performance liquid chromatography (HPLC). The results suggest that DLLE have anti-oxidative and anti-diabetic effects and thus, have the potential as anti-diabetic materials and as a source for natural health products. 3,4,7]. 최근의 고욤나무 열매 추출물에서 진정작용, 항당뇨, 항암, 항균효능, 항산화효능, 용혈작용, 신경보호 능이 세포 및 동물실험을 통해 확인되었다 [5,12,18,20,28]. 고욤 잎 추출 물에서는 항알러지 및 항가렴움증 및 항산화, 항염증, 간보호 능에 대한 효능이 보고되었다 [17,22,24]. 하지만 고욤잎 추출 (DLLE) 및 분획물에 대한 항산화 및 항당뇨 효능에 대한 보고 는 없다. 또한, 산화스트레스(oxidative stress)는 안정적인 상

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Antioxidant and Antiproliferative Activity of Diospyros lotus L. Extract and Isolated Compounds

Cited by 108 publications

References 29 publications

Cytotoxic action of methylquercetins in human lung adenocarcinoma cells

Cytotoxic action of methylquercetins in human lung adenocarcinoma cells

Biological activity and composition of teas and tinctures prepared from Rosa rugosa Thunb.

Anti-oxidant and α-Glucosidase Inhibition Activity of Extracts or Fractions from Diospyros lotus L. Leaves and Quantitative Analysis of Their Flavonoid Compounds

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