Antioxidant and antiproliferative activity of curcumin semicarbazone

Dutta, Sabari; Padhyé, Subhash; Priyadarsini, K. Indira; Newton, C. J.

doi:10.1016/j.bmcl.2005.04.001

Cited by 107 publications

(44 citation statements)

References 31 publications

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“…Curcumin is a natural compound that has been reported to have antioxidant, anti-inflammatory, and antiproliferative properties (1,7,22). In this study, we found that curcumin was a potent inhibitor of CVB3 replication.…”

Section: Curcumin Inhibits Replication Of Cvb3mentioning

confidence: 57%

“…The UPS is a major intracellular pathway for extralysosomal protein degradation (1,7,22,35). There are two coupled steps involved in protein degradation: (i) covalent attachment of ubiquitin to the target protein substrate and (ii) degradation of the polyubiquitinated protein by the proteasome with the release of recyclable ubiquitin.…”

mentioning

confidence: 99%

“…Recent studies have shown a promising potential for curcumin in the treatment of various forms of cancer and cardiovascular diseases (1,7,22,35). Curcumin has been reported to have profound anti-inflammatory, antioxidant, and antiproliferative properties, acting through modulation of multiple cellular machineries.…”

mentioning

confidence: 99%

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Dysregulation of the Ubiquitin-Proteasome System by Curcumin Suppresses Coxsackievirus B3 Replication

Wang

Wong

et al. 2007

J Virol

120

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Curcumin (diferuloylmethane), a natural polyphenolic compound extracted from the spice turmeric, has been reported to have anti-inflammatory, antioxidant, and antiproliferative properties by modulating multiple cellular machineries. It inhibits several intracellular signaling pathways, including the mitogen-activated protein kinases (MAPKs), casein kinase II (CKII), and the COP9 signalosome (CSN), in various cell types. It has also been recently demonstrated that exposure to curcumin leads to the dysregulation of the ubiquitinproteasome system (UPS). Coxsackievirus infection is associated with various diseases, including myocarditis and dilated cardiomyopathy. In searching for new antiviral agents against coxsackievirus, we found that treatment with curcumin significantly reduced viral RNA expression, protein synthesis, and virus titer and protected cells from virus-induced cytopathic effect and apoptosis. We further demonstrated that reduction of viral infection by curcumin was unlikely due to inhibition of CVB3 binding to its receptors or CVB3-induced activation of MAPKs. Moreover, gene silencing of CKII and Jab1, a component of CSN, by small interfering RNAs did not inhibit the replication of coxsackievirus, suggesting that the antiviral action of curcumin is independent of these pathways. Finally, we showed that curcumin treatment reduced both the 20S proteasome proteolytic activities and the cellular deubiquitinating activities, leading to increased accumulation of ubiquitinated proteins and decreased protein levels of free ubiquitin. We have recently demonstrated that the UPS-mediated protein degradation and/or modification plays a critical role in the regulation of coxsackievirus replication. Thus, our results suggest an important antiviral effect of curcumin wherein it potently inhibits coxsackievirus replication through dysregulation of the UPS.

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Section: Curcumin Inhibits Replication Of Cvb3mentioning

confidence: 57%

mentioning

confidence: 99%

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Dysregulation of the Ubiquitin-Proteasome System by Curcumin Suppresses Coxsackievirus B3 Replication

Wang

Wong

et al. 2007

J Virol

120

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“…Curcumin, a constitutent of a type of spice, has been demonstrated to have antioxidative (84,85), anti-inflammatory (84) and iron-chelating effects (86). These beneficial effects may provide vast benefits to iron overload TM patients.…”

Section: Possible Future Therapeutic Modalitiesmentioning

confidence: 99%

Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity

Lekawanvijit

Chattipakorn

2009

Canadian Journal of Cardiology

106

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“…The semicarbazone derivative of curcumin (CRSC, 66), has been described by our group which was evaluated for antioxidant, anti-proliferative, and radical scavenging activities [68]. CRSC was found to inhibit radiation induced lipid peroxidation in the rat liver microsomes at 10 M concentration.…”

Section: Modifications Of Diketo Functionality-das and Coworkersmentioning

confidence: 99%

Perspectives on New Synthetic Curcumin Analogs and their Potential Anticancer Properties

Vyas¹,

Dandawate²,

Padhyé³

et al. 2013

Current Pharmaceutical Design

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Curcumin is the active component of dried rhizome of Curcuma longa, a perennial herb belonging to ginger family, cultivated extensively in south and southeastern tropical Asia. It is widely consumed in the Indian subcontinent, south Asia and Japan in traditional food recipes. Extensive research over last few decades has shown that curcumin is a potent anti-inflammatory agent with powerful therapeutic potential against a variety of cancers. It suppresses proliferation and metastasis of human tumors through regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases and other enzymes. It induces apoptotic cell death and also inhibits proliferation of cancer cells by cell cycle arrest. Pharmacokinetic data has shown that curcumin undergoes rapid metabolism leading to glucuronidation and sulfation in the liver and excretion in the feces, which accounts for its poor systemic bioavailability. The compound has, therefore, been formulated and administered using different drug delivery systems such as liposomes, micelles, polysaccharides, phospholipid complexes and nanoparticles that can overcome the limitation of bioavailability to some extent. Attempts to avoid rapid metabolism of curcumin until now have been met with limited success. This has prompted researchers to look for new synthetic curcumin analogs in order to overcome the drawbacks of limited bioavailability and rapid metabolism, and gain efficacy with reduced toxicity. In this review we provide a summarized account of novel synthetic curcumin formulations and analogs, and the recent progress in the field of cancer prevention and treatment.

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Antioxidant and antiproliferative activity of curcumin semicarbazone

Cited by 107 publications

References 31 publications

Dysregulation of the Ubiquitin-Proteasome System by Curcumin Suppresses Coxsackievirus B3 Replication

Dysregulation of the Ubiquitin-Proteasome System by Curcumin Suppresses Coxsackievirus B3 Replication

Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity

Perspectives on New Synthetic Curcumin Analogs and their Potential Anticancer Properties

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