Antioxidant and antithrombotic properties of Dendropanax morbifera Léveille (Araliaceae) and its ferments produced by fermentation processing

Abstract

The present study investigates and evaluates the antioxidant and antithrombotic effects of Dendropanax morbifera Léveille (Araliaceae) extracts (DME) and its ferment (FDME). Antioxidant activities were improved by FDME treatment, especially 66.74% of hydroxyl radical scavenging activity was observed at 100 μg of FDME treatment.In vitro antithrombotic activity was also improved by accelerated fibrinolysis and blood clot degradation as well as prolonged prothrombin time. Similar to those results, in vivo experiment also showed that the formation of thrombus was alleviated and paralysis or death due to thromboembolism was also prevented to some extent. Practical applicationsA bioprocessing technology, fermentation is known to enhance nutritional qualities which has beneficial effects on health by improving antioxidant activity, lipid levels, and antithrombotic activities. DME, healthy food source has been known to have a potential for improving blood circulation improvement. The present study provides beneficial information on the potential and excellence of the antithrombotic efficacy of DME and FDME. The present results elucidate the antithrombotic activities of DME and FDME, which is useful in the development of new food materials for cardiovascular health and new antithrombotic agents for clinical application. K E Y W O R D Santioxidant, antithrombotic, Dendropanax morbifera Léveille (Araliaceae), fermentation

Cytotoxicity, metabolic enzyme inhibitory, and anti‐inflammatory effect of Lentinula edodes fermented using probiotic lactobacteria

“…The increase in biological activity yielded by the fermentation of these LAB is affected by various factors. Some studies have suggested an increase in the content of phenolic compounds or the degradability of the food material used after fermentation as a major factor in raising the physiological activity of LAB (Choi & Kim, 2019; Eom et al., 2010; Hur et al., 2014; Lee et al., 2016; Mun et al., 2015). Other studies have reported that the unique bioconversion process of each strain of LAB can be a crucial factor that may change the constituents of food materials used for fermentation and their biological activities (Kerry et al., 2018; Quinto et al., 2014).…”

Dihydroconiferyl Ferulate Isolated from Dendropanax morbiferus H.Lév. Suppresses Stemness of Breast Cancer Cells via Nuclear EGFR/c-Myc Signaling

“…Previous studies have shown that Dendropanax morbiferus H.Lév. exerts various biological activities, including antifungal [34], antibacterial [34], cytotoxic [35,36], antidiabetic [37], antioxidant [38,39], anti-inflammatory [40,41], hepatoprotective [42], neuroprotective [43,44], and anticancer [45] activities. The bioactive compounds contained in Dendropanax morbiferus H.Lév.…”

Microwave-Assisted Dendropanax morbifera Extract for Cosmetic Applications

“…[11,12]. Furthermore, previous studies reported that D. morbifera exhibits antioxidant [13,14], anti-inflammatory [15,16], neuroprotective [6,17], osteosarcoma [18], antidiabetic [19,20], hepatoprotective [21,22], immunomodulatory [16,23], antibacterial and antifungal [24], antiplasmodial [25], cytotoxic [26], and larvicidal [27] functions. Recently, interest in D. morbifera as a functional material in cosmetics has increased thanks to its well-rounded health benefits for humans.…”