Antioxidant and Antitumor Activities of Methanolic Extracts Obtained from Red Delicious and Granny Smith Apples' Seeds

Mustafa, Yasser Fakri; Mohammed, Eman Tareq; Khalil, Raghad Riyadh

doi:10.31838/srp.2020.4.84

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…Exploiting its content of bioactive compounds, Silybum marianum dried seeds extracts were used anciently in the treatment of many diseases especially diseases associated with liver and bile, in addition to its antimicrobial and anti-inflammatory activity. Extract's yield depends on many factors such as the type of solvent used, harvesting time, storage conditions, and geographic climate [17][18][19][20].…”

Section: Resultsmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Silybum marianum is a primitive compound mixture that has pharmaceutical and pharmacological activities. Studies have highlighted the role of Silybum marianum in treating candidiasis. The aim of the study was to evaluate the in vivo anticandidal and ulcer healing capacity of Silybum marianum-extract. Silybum marianum was prepared in aqueous extract which showed a positive result for the presence of four phytochemical compounds. In vitro anticandidal effect was reported for the extract against Candida albicans ATCC 7012. Animals were partitioned into three; group I treated with distilled water (negative control), group II treated with oral Silybum marianum-extract and group III treated with oral fluconazole (positive control). Treatment protocol was carried out for 7 days, then rats of three groups were sacrificed for histology and microbiology assessment. Silybum marianum-extract demonstrated a beneficial eradicating activity on C. albicans comparable to that of fluconazole and in enhancing ulcer healing rate (ulcer length: 810 µm vs 381.77 µm of negative control group and extract-treated group, respectively). Silybum marianum may be suggested as an alternative or an adjuvant therapy to standard existing drugs used for treatment of oral candidiasis.

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Section: Resultsmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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“…Coumarins are a class of naturally occurring O -heterocyclic compounds with 2 H -1-benzopyran-2-one as a core framework ( Figure 1 ) [ 6 , 7 ] Coumarins are widely recognized for their pharmacological effects in both natural and synthetic forms. They possess antifungal, antibacterial, anti-inflammatory, antioxidant, anti-cholinesterase, antidiabetic, antineoplastic, anti-HIV, anticoagulant, and anticancer bioactivities ( Figure 2 ) [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. For instance, the naturally occurring coumarin Calanolide A ( Figure 1 ), which was extracted from the species Calophyllum , showed interesting anti-HIV activity [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Trends in the Synthesis and Bioactivity of Coumarin, Coumarin–Chalcone, and Coumarin–Triazole Molecular Hybrids

Rohman,

Ardiansah,

Wukirsari

et al. 2024

Molecules

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Molecular hybridization represents a new approach in drug discovery in which specific chromophores are strategically combined to create novel drugs with enhanced therapeutic effects. This innovative strategy leverages the strengths of individual chromophores to address complex biological challenges, synergize beneficial properties, optimize pharmacokinetics, and overcome limitations associated with single-agent therapies. Coumarins are documented to possess several bioactivities and have therefore been targeted for combination with other active moieties to create molecular hybrids. This review summarizes recent (2013–2023) trends in the synthesis of coumarins, as well as coumarin–chalcone and coumarin–triazole molecular hybrids. To cover the wide aspects of this area, we have included differently substituted coumarins, chalcones, 1,2,3– and 1,2,4–triazoles in this review and considered the point of fusion/attachment with coumarin to show the diversity of these hybrids. The reported syntheses mainly relied on well-established chemistry without the need for strict reaction conditions and usually produced high yields. Additionally, we discussed the bioactivities of the reported compounds, including antioxidative, antimicrobial, anticancer, antidiabetic, and anti-cholinesterase activities and commented on their IC50 where possible. Promising bioactivity results have been obtained so far. It is noted that mechanistic studies are infrequently found in the published work, which was also mentioned in this review to give the reader a better understanding. This review aims to provide valuable information to enable further developments in this field.

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