Antioxidant and antiulcer activity of <i>Ziziphus rugosa</i> Lam. bark

Manjunatha, E; Murugan, Vedigounder.; Geetha, K; Nandeesh, R.; Ahmed, Syed Mansoor

doi:10.5958/0974-360x.2020.00831.8

Cited by 4 publications

(3 citation statements)

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“…Moreover, the ethanolic extract has antiulcer effectiveness against stomach lesions. Reduced gastrointestinal volume, gastric ulcer index, and percentage protection are signs of the antiulcer action, as are decreased acid secretory parameters (such as total and free acid) (Manjunatha et al 2020).In conclusion, the bioactive components and parts of the Ziziphus plant have shown substantial antioxidant efficacy both in vitro and in animal tests, suggesting their potential use in antioxidant therapy for chronic illnesses caused by ROS (reactive oxygen species).…”

Section: Antifungalmentioning

confidence: 89%

“…It is a 3-6 m tall small tree or large straggly thorny evergreen shrub. The tree's relatively firm, reddish-colored wood has five obovoid-globose or sub-globose fruits ranging from orange to black and is 9 to 12 mm long and 8 to 10 mm wide (Manjunatha et al 2020). Ashraf et al 2015, Prakash et al 2020, Uddin et al2021…”

Section: Plant Habit Distribution and Morphological Descriptionmentioning

confidence: 99%

“…Fruit is edible and nutrient-rich (Hassan et al 2021). However, Flowers and bark are used as an astringent, antidiarrheal, menorrhagia, hemorrhage, antifungal, antidiabetic, and anti-inflammatory (Manjunatha et al 2020).…”

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confidence: 99%

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A panoramic review on ethnomedicinal, therapeutic, phytochemical, and advance attributes, of the genus Ziziphus Mill., native to Pakistan

Imran,

Bibi,

Munawar

et al. 2023

Ethnobot. Res. App.

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Background: Medicinal plants have gained prime importance in treating several fatal diseases, such as cancer, diabetes, and eczema, because they are a rich source of bioactive phytochemicals and a safer alternative to synthesized chemical compounds. Genus Ziziphus Mill. belongs to the family Rhamnaceae, which comprises 100 accepted plant species and is well known for multipurpose applications such as food, fodder, fuels, medicine, timber, alcohol, cosmetics, poison, etc. Six species of the genus Ziziphus are indigenous to Pakistan, famous as Ziziphus nummularia (Burm.f.) Wight & Arn., Ziziphus mauritiana Lam., Ziziphus jujuba Mill., Ziziphus spina-christi (L.) Desf., Ziziphus rugosa Lam., Ziziphus oxyphylla Edgew.Method: Several search engines and online databases, including Sci-hub, PubMed, Google Scholar, Flora of Pakistan, research gate, and Science Direct, were used to perform an exhaustive literature survey for this review. Both original research studies and relevant review articles done till 2022 were included.Result: These species have been used in traditional and Ayurveda medicine to treat diseases like fever, skin infections, urinary problems, diabetes, etc. Numerous components of Ziziphus species have been found, alkaloids, flavonoids, phenols, terpenoids, and organic acids, to exhibit a variety of biological properties, including anticancer, antimicrobial, anti-hair fall, antinociceptive, antipyretic, larvicidal, and anti-diabetic actions.Conclusion: This review demonstrates the phytochemical composition, traditional uses, pharmacological properties, and nanoparticle-based activity of the genus Ziziphus and lays down a scientific foundation for further investigation on the usage of Ziziphus. Moreover, this review indicates that jujube has a hair growth effect because of its high nutritional value and pharmacological activities.

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Section: Antifungalmentioning

confidence: 89%

Section: Plant Habit Distribution and Morphological Descriptionmentioning

confidence: 99%

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A panoramic review on ethnomedicinal, therapeutic, phytochemical, and advance attributes, of the genus Ziziphus Mill., native to Pakistan

Imran,

Bibi,

Munawar

et al. 2023

Ethnobot. Res. App.

View full text Add to dashboard Cite

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Promising Pharmacological Activities of Ziziphus Herbal Extract and its Formulations

Pal,

Halder,

Das

et al. 2023

RJPT

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The aim of the present research is to study the potential pharmacological activities of herbal extract of Ziziphus and its formulations. It is observed that the plant extracts of different species of Ziziphus have a variety of pharmacological activities. Due to antibiotic resistance, it is necessary to discover new sources of antibiotics. New technologies are used for the development of antimicrobial and antioxidant drugs with enhanced pharmacological activities. Also, scientists are concentrating on herbal medicines because of their numerous advantages over synthetic drugs. Now-a-days many of these herbal formulations, sold over the counter, are not properly standardized for quality and toxicity. In this research work the sub-chronic dermal toxicity study of Ziziphus oenoplia leaf extract containing Carbopol hydrogel formulation is evaluated on adult male Albino Wister rats. Here, the extract containing hydrogel in 3 doses, and 0.9% NaCl solution (negative control) has been applied on the shaved area of dorsolateral trunk of different groups of rats once a day for 28 days for the study. After conduction of the experiment, it has been observed that the control as well as the test groups of animals did not possess any mortality/ morbidity, clinical signs of toxicity or skin reactions such as edema or erythema. There has been no significant change in food consumption or any notable elevation in body weight in the animal groups throughout the experimental period. Thus, in this study the Ziziphus extract incorporated Carbopol hydrogel has been successfully evaluated for dermal toxicity which reveals that the formulation can be safely applied dermally for wound healing purpose.

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Isolation, Characterization and In-silico screening of compounds from Ziziphus rugosa bark for their Antiulcer effect

Vedigounder,

K M

et al. 2024

RJPT

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To explore the interaction of compounds isolated from Ziziphus rugosa (Rahmnaceae) with human Histamine H2 and H/K+ ATPase receptor proteins for In-silico antiulcer activity the present study was performed. Because of the exceptional availability of phytoconstituents as pure chemicals in natural products or standardised extracts, the possibilities for innovative drug development are nearly limitless. Ziziphus rugosa (Rahmnaceae) is one of the traditional medicinal plant used in treatment of various ailments and the ethanolic extract of its bark is reported to have antiulcer activity. Four compounds were isolated form the ethanolic extract of bark to explore the interaction of isolated compounds with human Histamine H2 and H/K+ ATPase receptor proteins. We performed molecular docking studies using AutoDock4.2, non-targeted and local docking approaches were employed for the binding mode and interaction study of antiulcer compounds. From the results, Ligand [(4-[(E)-2-(5-ethyl-7-hydroxyquinazolin-2-yl) ethenyl]-2-methyl cyclohexane-1-carboxylic acid] showed binding affinity score -8.26 kcal/mol with Histamine-H2 receptor and The ligand Beutilinc acid showed binding affinity score of -6.68 kcal/mol for (H+ /K+ -ATPase) receptor. From these studies, it is demonstrated that Ziziphus rugosa bark consists of potential leads for ulcer healing activity as revealed by in silico studies.

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Antioxidant and antiulcer activity of Ziziphus rugosa Lam. bark

Cited by 4 publications

References 0 publications

A panoramic review on ethnomedicinal, therapeutic, phytochemical, and advance attributes, of the genus Ziziphus Mill., native to Pakistan

A panoramic review on ethnomedicinal, therapeutic, phytochemical, and advance attributes, of the genus Ziziphus Mill., native to Pakistan

Promising Pharmacological Activities of Ziziphus Herbal Extract and its Formulations

Isolation, Characterization and In-silico screening of compounds from Ziziphus rugosa bark for their Antiulcer effect

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