Antioxidant and cholesterol regulatory effect of flavonoid-rich silk sericin

Lee, Ji Hae; Kim, Yeon-Ji; Kim, Kyungho; Kweon, HaeYong; Kim, Hyun-bok; Kim, Seong Ryul; Kim, Seong-Wan; Park, Jong Woo; Kang, Sang Kuk

doi:10.1007/s10068-024-01527-x

Food Sci Biotechnol

2024

DOI: 10.1007/s10068-024-01527-x

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Antioxidant and cholesterol regulatory effect of flavonoid-rich silk sericin

Ji Hae Lee,

Yeon-Ji Kim,

Kyungho Kim

et al.

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Oral Toxicity and Hypotensive Influence of Sericin-Derived Oligopeptides (SDOs) from Yellow Silk Cocoons of Bombyx mori in Rodent Studies

Tocharus,

Prum,

Sutheerawattananonda

2024

Foods

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Sericin-derived oligopeptides (SDOs) from yellow silk cocoons exhibit antihypertensive and hypoglycemic properties in both in vitro and in vivo studies. This study investigated the acute toxicity of SDOs as a novel food for human consumption using female ICR mice and Wistar rats, as well as the chronic toxicity test on both sexes of Wistar rats. Clinical chemistry, hematology, and histopathological studies revealed that SDOs were safe for a single dose of 2000 mg kg−1 body weight (BW) and daily oral administration of 50, 100, and 200 mg kg−1 BW for six months. The chronic toxicity study additionally measured the rats’ systolic blood pressure (SBP) and blood sugar monthly as they slowly aged. In the 2nd month for male rats and the 4th month for both sexes, SDOs had a significant hypotensive effect on Wistar rats’ blood pressure, lowering it from 130 mmHg to a plateau at 110–115 mmHg. In contrast, the blood pressure of the control rats exceeded 140 mmHg after five months. Nonetheless, the hypoglycemic effect was not observed. Measurements of SBP and blood glucose in aged rats during chronic toxicity tests yielded insights beyond ordinary toxicity, including the health and fitness of the lab rats, perhaps resulting in novel discoveries or areas of study that justify the sacrifice of the animals’ lives.

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Oral Toxicity and Hypotensive Influence of Sericin-Derived Oligopeptides (SDOs) from Yellow Silk Cocoons of Bombyx mori in Rodent Studies

Tocharus,

Prum,

Sutheerawattananonda

2024

Foods

View full text Add to dashboard Cite

show abstract

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Antioxidant and cholesterol regulatory effect of flavonoid-rich silk sericin

Cited by 1 publication

References 18 publications

Oral Toxicity and Hypotensive Influence of Sericin-Derived Oligopeptides (SDOs) from Yellow Silk Cocoons of Bombyx mori in Rodent Studies

Oral Toxicity and Hypotensive Influence of Sericin-Derived Oligopeptides (SDOs) from Yellow Silk Cocoons of Bombyx mori in Rodent Studies

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