Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease

Shih, Ping‐Hsiao; Chan, Yin-Ching; Liao, Jiunn‐Wang; Wang, Mingfu; Yen, Gow‐Chin

doi:10.1016/j.jnutbio.2009.03.008

Cited by 179 publications

(102 citation statements)

References 51 publications

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“…AD and Aβ accumulation are inextricably linked with oxidative damage (Smith et al 1995). Diet supplements with mulberry (a resveratrol-rich fruit) improved not only memory impairment and decreased Aβ accumulation in SAMP8 but also increased antioxidant capacity via the antioxidant response element (ARE)-Nrf2 pathway in the liver and brain (Shih et al 2010). Furthermore, resveratrol has been reported to improve memory alterations as it preserved cognitive function in aging mice (Oomen et al 2009) and in transgenic AD mice (Kim et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

Porquet

Casadesús

Bayod

et al. 2012

AGE

232

162

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Resveratrol is a polyphenol that is mainly found in grapes and red wine and has been reported to be a caloric restriction (CR) mimetic driven by Sirtuin 1 (SIRT1) activation. Resveratrol increases metabolic rate, insulin sensitivity, mitochondrial biogenesis and physical endurance, and reduces fat accumulation in mice. In addition, resveratrol may be a powerful agent to prevent age-associated neurodegeneration and to improve cognitive deficits in Alzheimer's disease (AD). Moreover, different findings support the view that longevity in mice could be promoted by CR. In this study, we examined the role of dietary resveratrol in SAMP8 mice, a model of age-related AD. We found that resveratrol supplements increased mean life expectancy and maximal life span in SAMP8 and in their control, the related strain SAMR1. In addition, we examined the resveratrol-mediated neuroprotective effects on several specific hallmarks of AD. We found that longterm dietary resveratrol activates AMPK pathways and pro-survival routes such as SIRT1 in vivo. It also reduces cognitive impairment and has a neuroprotective role, decreasing the amyloid burden and reducing tau hyperphosphorylation.

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Section: Discussionmentioning

confidence: 99%

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

Porquet

Casadesús

Bayod

et al. 2012

AGE

232

162

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“…Total phenolic constituents of LOE were determined with the Folin-Ciocalteu reagent, using gallic acid as a standard (Slinkard and Singleton 1977). Total flavonoid contents were measured with an aluminum chloride colorimetric assay, with rutin used as a standard (Shih et al 2010). …”

Section: Gas Chromatography-mass Spectrometry (Gc-ms)mentioning

confidence: 99%

The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice

Lin

Chen

Wang

et al. 2013

AGE

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We investigated the anti-aging effects of Ludwigia octovalvis (Jacq.) P. H. Raven (Onagraceae), an extract of which is widely consumed as a healthful drink in a number of countries. Using the fruit fly, Drosophila melanogaster, as a model organism, we demonstrated that L. octovalvis extract (LOE) significantly extended fly lifespan on a high, but not a low, calorie diet, indicating that LOE may regulate lifespan through a dietary restriction (DR)-related pathway. LOE also attenuated age-related cognitive decline in both flies and in the senescence-accelerated-prone 8 (SAMP8) mouse, without causing any discernable negative trade-offs, including water intake, food intake, fecundity, or spontaneous motor activity. LOE contained high levels of polyphenols and flavonoids, which possess strong DPPH radical scavenging activity, and was shown to attenuate paraquat-induced oxidative damage and lethality in flies. Gas chromatography-mass spectrometry (GC-MS) analyses identified 17 known molecules, of which β-sitosterol and squalene were the two most abundant. We further demonstrated that β-sitosterol was capable of extending lifespan, likely through activating AMP-activated protein kinase (AMPK) in the fat body of adult flies. Taken together, our data suggest that LOE is a potent anti-aging intervention with potential for treating age-related disorders.

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“…Black mulberry contains bioflavonoids that are important natural antioxidants and also contains nonanthocyanin phenolics that are known to have many bioactive functions, including neuroprotective effects, which may be responsible for their medicinal properties (Ercisli and Orhan 2007;Shih et al 2010). To the best of our knowledge, the effect of M. nigra on cognitive impairment has not been investigated yet.…”

Section: Introductionmentioning

confidence: 99%

Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice

Turgut

Mert

Kara

et al. 2015

Pharmaceutical Biology

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Context: Morus nigra L. (Moraceae) has various uses in traditional medicine. However, the effect of M. nigra on cognitive impairment has not been investigated yet. Objective: The objective of this study is to determine the phenolic acid content and DNA damage protection potential of M. nigra leaf extract and to investigate the extract effect on cognitive impairment and oxidative stress in aging mice. Materials and methods: Phenolic acid content was determined by quantitative chromatographic analysis. DNA damage protection potential was evaluated on pBR322 plasmid DNA. Thirty-two Balb-C mice were randomly divided into four groups (control, D-galactose, D-galactose + M. nigra 50, and D-galactose + M. nigra 100). Mice were administered D-galactose (100 mg/kg, subcutaneous) and M. nigra (50 or 100 mg/kg, orally) daily for 8 weeks. Behavioral responses were evaluated with Morris water maze. Activities of antioxidant enzymes and levels of malondialdehyde (MDA) were assayed in serum, brain, and liver. Results: In extract, vanillic (632.093 mg/g) and chlorogenic acids (555.0 mg/g) were determined. The extract between 0.02 and 0.05 mg/mL effectively protected all DNA bands against the hazardous effect of UV and H 2 O 2 . Morus nigra significantly improved learning dysfunctions (p 50.01), increased memory retention (p50.01), reduced MDA levels (p50.05), and elevated SOD, GPx, and CAT activities (p50.05) compared with the D-galactose group. Discussion and conclusion: These results show that M. nigra has the potential in improving cognitive deficits in mice and that M. nigra may be useful to suppress aging, partially due to its scavenging activity of free radicals and high antioxidant capacity. ARTICLE HISTORY

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Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry (Morus atropurpurea L.) on senescence-accelerated mice and prevention of Alzheimer's disease

Cited by 179 publications

References 51 publications

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

The anti-aging effects of Ludwigia octovalvis on Drosophila melanogaster and SAMP8 mice

Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice

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