Antioxidant and Cyclooxygenase Activities of Fatty Acids Found in Food

Abstract

Several commercially available C-8 to C-24 saturated and unsaturated fatty acids (1-29) were assayed for cyclooxygenase-I (COX-I) and cyclooxygenase-II (COX-II) inhibitory and antioxidant activities. Among the saturated fatty acids tested at 60 microg mL(-1), there was an increase in antioxidant activity with increasing chain length from octanoic acid to myristic acid (C-8-C-14) and a decrease thereafter. All unsaturated fatty acids tested at 60 microg mL(-1) showed good antioxidant activity except for undecylenic acid (12), cis-5-dodecenoic acid (13), and nervonic acid (29). The highest inhibitory activities among the saturated fatty acids tested on cyclooxygenase enzymes COX-I and COX-II were observed for decanoic acid to lauric acid (3-5) at 100 microg mL(-1). Similarly, among the unsaturated fatty acids tested, the highest activities were observed for cis-8,11,14-eicosatrienoic acid (25) and cis-13,16-docosadienoic acid (27) at 100 microg mL(-1).

In Vitro effect of D‐004, a lipid extract of the ground fruits of the cuban royal palm (Roystonea regia), on rat microsomal lipid peroxidation

“…that saturated and unsaturated FA, such as myristic, stearic, palmitic, oleic and several oil extracts containing FA, inhibit in vitro both COX and LOX (PaubertBanquet et al, 1997;Yehoshua et al, 1999;Mogul et al, 2000;Henry et al, 2002;Zhang et al, 2002;Gonzalez et al, 2003), which reinforces the validity of the results found here with D-004. Therefore, the inhibition of both LOX and COX activity may explain why the antioxidant activity of D-004 is higher in native than in heatinactivated microsomes, since in this latter condition the LP cellular damage is entirely attributed to non enzymatic mechanisms, and the inhibitory effects of D-004 on both LOX and COX cannot be present to produce a greater overall antioxidant effect.…”

“…In line with these facts, it was found that the oral administration of D-003, a mixture of very long chain FA isolated from sugarcane wax, inhibited tissue and lipoprotein LP in experimental models and humans (Castaño et al, 2003). Also, medium and long chain saturated and unsaturated FAs have inhibited in vitro LP (Henry et al, 2002, Zhang et al, 2002 showing oxygen free radical scavenger activity (Chan et al, 1996). Therefore, this study was undertaken to assess whether D-004 displayed in vitro antioxidant effects.…”

Anti-ulcerogenic activity of virgin coconut oil contribute to the stomach health of humankind

“…linoleic acid, oleic acid, lauric acid) activities (Henry et al, 2002). Interestingly, the fatty acid compositions of VCOs and CO were comparable to the Codex standards and previous studies (Henry et al, 2002). On the other hand, the difference in antiulcer intensity between the oils could be associated with the way they were processed.…”

“…palmitic acid, myristic acid) and anti-inflammatory (i.e. linoleic acid, oleic acid, lauric acid) activities (Henry et al, 2002). Interestingly, the fatty acid compositions of VCOs and CO were comparable to the Codex standards and previous studies (Henry et al, 2002).…”

Cosmeceuticals Derived from Bioactive Substances Found in Marine Algae

“…Most of the PUFAs have good antioxidant activities [95]. 16 species of seaweeds collected along the Qingdao coastline were screened and evaluated for their antioxidant activities using the β-carotenelinoleate assay system [96].…”