Antioxidant and Cytotoxic Activities of Distillates Purified by Means of Molecular Distillation from Ginger Extract Obtained with Supercritical CO<sub>2</sub> Fluid

Wang, Lixia; Zhao, Wenhua; Lü, Yifei; Wang, Chenxu

doi:10.1002/cbdv.201900357

Cited by 8 publications

(2 citation statements)

References 60 publications

(113 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The anti-inflammatory activity of 6-GN has been attributed to the inhibition of pro-inflammatory cytokines and antigen presentation by LPS-activated macrophages. In vitro, 6-GN has shown to inhibit LPS-induced NOS and COX-2 in murine RAW 264.7 cells [ 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Effectiveness of a Supplement Combining Harpagophytum procumbens, Zingiber officinale and Bixa orellana in Healthy Recreational Runners with Self-Reported Knee Pain: A Pilot, Randomized, Triple-Blind, Placebo-Controlled Trial

González‐Gross

Quesada-González

Rueda

et al. 2021

IJERPH

View full text Add to dashboard Cite

Recreational running (RR) is becoming a popular way to increase physical activity for improving health, together with a higher incidence of knee injuries. The aim was to analyze the effect of a four-week supplementation with a mixture of Harpagophytum procumbens, Zingiber officinale and Bixa orellana on males, middle-aged, RR with an undiagnosed knee discomfort. A randomized triple-blind placebo-control trial was conducted among male RR aged 40–60 years suffering from self-declared knee discomfort after training. Participants were assigned to supplementation (2 g/day in 6 doses; n = 13; intervention group (IG)) or matched placebo (n = 15; control group (CG)) for 4 weeks. At pre- and post-intervention, assessment of routine blood biomarkers, body composition, running biomechanics and body temperature was performed using standardized procedures. Machine learning (ML) techniques were used to classify whether subjects belonged to IG or CG. ML model was able to correctly classify individuals as IG or CG with a median accuracy of 0.857. Leg fat mass decreased significantly (p = 0.037) and a deeper reduction in knee thermograms was observed in IG (p < 0.05). Safety evaluation revealed no significant differences in the rest of parameters studied. Subjects belonging to IG or CG are clearly differentiated, pointing into an effect of the supplement of ameliorating inflammation.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of Effectiveness of a Supplement Combining Harpagophytum procumbens, Zingiber officinale and Bixa orellana in Healthy Recreational Runners with Self-Reported Knee Pain: A Pilot, Randomized, Triple-Blind, Placebo-Controlled Trial

González‐Gross

Quesada-González

Rueda

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Ginger is not only a condiment vegetable but also a spice and medicinal herb, which is desirable in daily life (Wang, Zhao, Lu, & Wang, 2019). Meanwhile, gingers are widely cultivated in China, India, Nepal and other Asian countries and play an important role in international trade, which make fresh ginger so valuable (Wang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Composite coatings based on konjac glucomannan and sodium alginate modified with allicin and in situ SiOx for ginger rhizomes preservation

Wang

et al. 2020

Journal of Food Safety

View full text Add to dashboard Cite

Ginger is a condiment vegetable and widely cultivated in many countries for its important role as spice and medicinal herb in international trade. However, the quality of fresh ginger will reduce after harvest and during storage. In the present study, edible coatings were developed based on konjac glucomannan (KGM) and sodium alginate (SA), incorporating with allicin and in situ SiOx. The coatings were characterized, and the effects of the coatings on the quality of ginger were evaluated. The results demonstrate that the addition of allicin improve the compatibility of KGM and SA in film, and the addition of allicin and in situ SiOx promote more hydrogen bond formation in the film. The physicochemical properties of KGM/SA film are improved due to modification, and allicin coating is optimal for mechanical properties, while allicin‐SiOx film is optimal both for mechanical properties and gas barrier. The KGM/SA coatings especially KGM/SA‐allicin‐SiOx significantly inhibited the total phenol, flavonoid, total soluble sugars content, enzyme activities such as peroxidase (POD), polyphenol oxidase (PPO), and cellulase of gingers during storage. In addition, KGM/SA coatings effectively preserved the ascorbic acid (AsA), and titratable acidity (TA). Over all, KGA/SA coatings, especially with allicin and in situ SiOx, exhibited more significant and positive effects on quality of gingers during storage. Therefore, the KGM/SA coatings are promising in gingers preservation.

show abstract

Identification of Five Flavonoid Compounds from the Remaining Ginger Powder Purified by Using High-Speed Counter-Current Chromatography and Their Bioactivity

Wang

Zhang

et al. 2021

Food Anal. Methods

View full text Add to dashboard Cite

HSCCC was widely used as a reliable and efficient tool for isolation of natural production. Multiple active compounds were separated and purified from ginger essential oil. But the remaining ginger powder (RGP), which was obtained from ginger without volatile oil, was discarded commonly. The crude flavonoids were extracted from RGP using ethanol at 80°C. The purification of flavonoids was performed by rotary evaporator and X-5 macroporous adsorption resin. The high-speed counter-current chromatography (HSCCC) was implemented by employing a two-phase solvent system which consist of n-hexane-ethyl acetate-methanol-water (4:5:4:5, v/v/v/v) and n-hexane-ethyl acetate-methanol-water (1:5:1:5, v/v/v/v) to separate flavonoid into five fractions. The purity of individual flavonoid in each of the fraction was analyzed by highperformance liquid chromatography (HPLC). The chemical structures of the isolated compounds were identified by liquid chromatograph mass spectrometry-ion trap-time of flight (LCMS-IT-TOF). Rutin (16.6%), tangeretin (13.1%), vitexin (18.37%), myricetin-3-O-glucopyranoside (3.3%), and isoquercitrin (15.2%) were identified in RGP at the purity of all over 90%. The HSCCC appeared to be an efficient and reliable method for the isolation of flavonoids in RGP. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to determine the anti-tumor abilities of five flavonoid compounds. The results showed that rutin and myricetin-3-O-glucopyranoside had better anti-tumor activities than other three flavonoid compounds from RGP. The research revealed that RGP was a bioactive product and contributed to development of ginger. KeywordsRemaining ginger powder • High-speed counter-current chromatography • High-performance liquid chromatography • Liquid chromatograph mass spectrometry-ion trap-time of flight • Anti-tumor activity * Li-xia Wang

show abstract

Antioxidant and Cytotoxic Activities of Distillates Purified by Means of Molecular Distillation from Ginger Extract Obtained with Supercritical CO₂ Fluid

Cited by 8 publications

References 60 publications

Analysis of Effectiveness of a Supplement Combining Harpagophytum procumbens, Zingiber officinale and Bixa orellana in Healthy Recreational Runners with Self-Reported Knee Pain: A Pilot, Randomized, Triple-Blind, Placebo-Controlled Trial

Analysis of Effectiveness of a Supplement Combining Harpagophytum procumbens, Zingiber officinale and Bixa orellana in Healthy Recreational Runners with Self-Reported Knee Pain: A Pilot, Randomized, Triple-Blind, Placebo-Controlled Trial

Composite coatings based on konjac glucomannan and sodium alginate modified with allicin and in situ SiOx for ginger rhizomes preservation

Identification of Five Flavonoid Compounds from the Remaining Ginger Powder Purified by Using High-Speed Counter-Current Chromatography and Their Bioactivity

Contact Info

Product

Resources

About

Antioxidant and Cytotoxic Activities of Distillates Purified by Means of Molecular Distillation from Ginger Extract Obtained with Supercritical CO2 Fluid

Cited by 8 publications

References 60 publications

Analysis of Effectiveness of a Supplement Combining Harpagophytum procumbens, Zingiber officinale and Bixa orellana in Healthy Recreational Runners with Self-Reported Knee Pain: A Pilot, Randomized, Triple-Blind, Placebo-Controlled Trial

Analysis of Effectiveness of a Supplement Combining Harpagophytum procumbens, Zingiber officinale and Bixa orellana in Healthy Recreational Runners with Self-Reported Knee Pain: A Pilot, Randomized, Triple-Blind, Placebo-Controlled Trial

Composite coatings based on konjac glucomannan and sodium alginate modified with allicin and in situ SiOx for ginger rhizomes preservation

Identification of Five Flavonoid Compounds from the Remaining Ginger Powder Purified by Using High-Speed Counter-Current Chromatography and Their Bioactivity

Contact Info

Product

Resources

About

Antioxidant and Cytotoxic Activities of Distillates Purified by Means of Molecular Distillation from Ginger Extract Obtained with Supercritical CO₂ Fluid