Antioxidant and cytotoxic activity of polyphenolic compounds isolated from the leaves of<i>Leucenia leucocephala</i>

Haggag, Eman; Kamal, Ahmed A. M.; Abdelhady, Mohamed; El-Sayed, Mortada; El-Wakil, Eman Ahmed; Abd-El-Hamed, Sayed S

doi:10.3109/13880209.2011.568623

Cited by 26 publications

(17 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the point of controlling the side effects of chemical drugs used in the treatment of cancer, seeking drugs of natural origin becomes mandatory. Hepatocellular carcinoma (HepG2) cells represent one of the most widely used experimental models for in vitro studies on liver cancer (Haggag et al, 2011). Our results are in accordance with previous results on cytotoxic activity of entomopathogenic fungi; Zhang et al (2004) demonstrated that the cytotoxic activity of ethyl acetate extracts of Cordyceps sinensis on human leukemia cell line was high.…”

Section: Discussionsupporting

confidence: 91%

Snailicidal, antimicrobial, antioxidant and anticancer activities of Beauveria bassiana, Metarhizium anisopliae and Paecilomyces lilacinus fungal extracts

Abdel–Wareth¹,

Ghareeb²,

Abdel‐Aziz³

et al. 2019

Egypt. J. of Aquatic Biolo. and Fish.

View full text Add to dashboard Cite

Fungi are capable of producing a wide variety of secondary metabolites. Entomopathogenic fungi along with species which parasitize nematodes represent excellent candidates for bioactive compounds production. This study aimed at exploring the snailicidal, antimicrobial and antioxidant activities of ethyl acetate and acetone extracts of Beauveria bassiana, Metarhizium anisopliae and Paecilomyces lilacinus. Ethyl acetate and acetone extracts were prepared and tested against Biomphalaria alexandrina snails, their antioxidant and antimicrobial activities were also investigated. The anticancer activity of P. lilacinus acetone extract was tested on hepatocellular carcinoma (HepG2) cells. Acetone extract of P. lilacinus (LC 50 =120 ppm) was more toxic to B. alexandrina snails than that of B. bassiana (LC 50 = 231 ppm). Sublethal concentrations of both extracts adversely affected survival rate, histological pattern of digestive and hermaphrodite glands of the tested snails, besides their genotoxicity to DNA of snails. P. lilacinus acetone extract showed the highest antioxidant activity. Also, its antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans was high. Moreover, it was cytotoxic to HepG2 cells (IC 50 =2.81 µg/ml). GC/MS analysis indicated the presence of 37 compounds in B. bassiana acetone extract with 2-methylhept-2,6-dien-4-ol and 1,3-dimethoxy-2-(hydroxymethyl)-9h-xanthene as major compounds. While 48 compounds were identified in P. lilacinus acetone extract where hexadecanoic acid, methyl ester and 10, 13 octadecadienoic acid, methyl ester were the major compounds. In conclusion, B. bassiana and P. lilacinus are excellent sources of bioactive compounds which have multiple biological effects. Pomacea canaliculata (Maketon et al., 2009). Generally, diverse toxic metabolites have been described in several fungal biological control agents including Beauveria, Metarhizium and Pacilomyces (Vey et al., 2001), some of these metabolites have been found to possess antibiotic, fungicidal or insecticidal properties (

show abstract

Section: Discussionsupporting

confidence: 91%

Snailicidal, antimicrobial, antioxidant and anticancer activities of Beauveria bassiana, Metarhizium anisopliae and Paecilomyces lilacinus fungal extracts

Abdel–Wareth¹,

Ghareeb²,

Abdel‐Aziz³

et al. 2019

Egypt. J. of Aquatic Biolo. and Fish.

View full text Add to dashboard Cite

show abstract

“…The results were in coordination with antimicrobial effect of WMRE as indicated by zone of inhibition in the present study. Haggag et al (2011) and Mushtaq et al (2015) also attributed antibacterial activity of WMRE to high phenolic compounds (110.85 ± 8.85 mg GAE/g of freshWRM extracts).…”

Section: Microbial Qualitymentioning

confidence: 97%

Antioxidant and antimicrobial efficacy of watermelon rind extract (WMRE) in aerobically packaged pork patties stored under refrigeration temperature (4±1°C)

Kumar

Mehta

Malav

et al. 2018

J Food Process Preserv

View full text Add to dashboard Cite

The present study was undertaken to evaluate antioxidant and antimicrobial efficacy of ethanolic extract of watermelon rind (WMRE) incorporated at 0.10% level in pork patties. The selected patties along with positive control (with 0.02% butylated hydroxyl anisole) and control samples were packaged in aerobic packaging and evaluated for various oxidative and microbiological stability parameters for 28 days under refrigeration (4 ± 1°C). The indicators of lipid peroxidation viz. thiobarbituric acid reactive substances (TBARS), free fatty acids (FFA) and peroxide value (PV) showed an increasing trend for control as well as treated products; however, treated product showed a significantly (P < 0.05) lower value than control. Microbiological and sensory qualities were maintained better for treatment throughout storage period. Thus, WMRE has potential to enhance storage stability of aerobically packaged pork patties stored at refrigeration temperature (4 ± 1°C) owing to its antioxidant and antimicrobial potency. Practical applications A huge quantity of watermelon rind is generated each year from watermelon fruit industry and their proper disposal remains a major environmental concern. The rind is very rich source of valuable bioactive compounds exerting antioxidant and antimicrobial effect. By harvesting through suitable extraction protocols and innovative processing technologies, these compounds could be utilized in developing functional meat products with higher antioxidant and antimicrobial properties, resulting in their improved oxidative stability and extension of storage life. This would also ensure profitable returns to farmers and proper disposal of watermelon rind thus ushering overall integrated development of agro‐meat industry.

show abstract

“…Awareness regarding the cumulative biological characteristics of phenolics, including anti-inflammatory, antibacterial, vasodilatory actions, anticarcinogenic, antiviral, antithrombotic, antiallergic, and hepatoprotective effects (Del Bano et al 2006;Jayaram and Dharmesh 2011;Turner et al 2005), have led to the extensive study of the bioactivities of these plant materials (Haggag et al 2011). During the present study, plant cell walls were enzymatically treated by cellulasic, pectinase, and hydrolytic enzymes (acid cellulase), which ultimately improved the liberation of glycosidically entrapped phenolic compounds.…”

Section: Phenolic Compounds In Clpmentioning

confidence: 99%

Optimization of Enzyme-assisted Revalorization of Sweet Lime (Citrus limetta Risso) Peel into Phenolic Antioxidants

Mushtaq¹,

Sultana²,

Bhatti³

et al. 2014

BioResources

View full text Add to dashboard Cite

Enzymatic treatment was used to induce liberation of antioxidant phenolics from under-utilized sweet lime peel (CLP). Small rotatable central composite design (SRCCD) was selected to optimize the conditions of enzymatic processing, i.e., enzyme concentration (2 to 5%), pH (5 to 8), temperature (30 to 75 °C), and incubation time (30 to 120 min). The morphological characterization of enzymatically hydrolyzed CLP was performed using field emission scanning electron microscopy (FESEM). Extracts obtained under suitable conditions were characterized for their phenolic profile by use of reverse-phase high-performance liquid chromatography coupled with a diode array detector (RP-HPLC-DAD) and evaluated for in vitro antioxidant activities. The observed results revealed that optimum enzymatic pre-treatment doubled the recovery of phenolic antioxidants with maximum Trolox equivalent antioxidant capacity (TEAC) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging potential (IC50). The observed results indicate that enzyme-assisted extraction might be a green choice to revalorize agro-processing residues.

show abstract

Antioxidant and cytotoxic activity of polyphenolic compounds isolated from the leaves ofLeucenia leucocephala

Abstract: These findings demonstrate that the leaves of L. leucocephala contain a considerable amount of polyphenolic compounds with high antioxidant properties, thus it has great potential as a source for natural health products.

Cited by 26 publications

References 35 publications

Snailicidal, antimicrobial, antioxidant and anticancer activities of Beauveria bassiana, Metarhizium anisopliae and Paecilomyces lilacinus fungal extracts

Snailicidal, antimicrobial, antioxidant and anticancer activities of Beauveria bassiana, Metarhizium anisopliae and Paecilomyces lilacinus fungal extracts

Antioxidant and antimicrobial efficacy of watermelon rind extract (WMRE) in aerobically packaged pork patties stored under refrigeration temperature (4±1°C)

Optimization of Enzyme-assisted Revalorization of Sweet Lime (Citrus limetta Risso) Peel into Phenolic Antioxidants

Contact Info

Product

Resources

About