Antioxidant and Cytotoxicity Potential of Six Synthesized Chalcones

Abstract

Background: Chalcones are open-chain flavonoids which display a large number of pharmacological activities such as cytotoxic, anti-inflammatory including antioxidant. The objective of this study was to assess antioxidant and cytotoxic activity of six synthesized chalcones. Methodology: For the current experiments, 1,3-diphenylpropenone (compound R) was used as molecular model to synthetize six compounds, namely three benzyl-benzimidazolyl-chalcones (U1, U2, WAC1) and three imidazopyridinyl-chalcones (V1, V2, V3). All the compounds were evaluated for their ability to scavenge the stable free ABTS •+ radical cation, according to the method develop by Choong et al. In addition, the cytotoxicity test described by Price et al., was performed using healthy human cell line, then in human malignant cell lines (HEP-2, A549). Results: All synthesized chalcones reduced the ABTS •+ radical cation. Indeed, benzyl benzimidazolyl compounds WAC1, U1, U2, by developing respectively 39.61%, 66.09%, and 84.20% percentages of reduction, showed an antioxidant effect 6, 11 and 14 times greater than the compound R (6.14%). As a result, imidazopyridinyl-chalcones compounds, namely V1, V2 and V3 reduced the ABTS •+ radical cation at 91.62%, 99.84% and 97.45% respectively, being 15 and 16 times more active than the compound R.

Uterotrophic activities of the aqueous extract of Moringa oleifera (Moringaceae) Lam. 1785 on young ovariectomized rats

“…This Moringaceae from the Ivorian pharmacopoeia appears to be one of the most promising species, given its nutrient content and its phytochemical compounds (Yang et al, 2006). These assets have allowed researchers to study its immunomodulatory (Shaila et al, 2010) and hepatoprotective (Panda et al, 2013), anti-tumor (Purwal et al, 2010) and estrogenic properties (Kouakou et al, 2018) and in the treatment of many other pathologies. However, these utero-trophic properties are less elucidated.…”