Antioxidant and detoxifying enzymes in the liver and kidney of pheasants after intoxication by herbicides MCPA and ANITEN

Holovská, K.; Lenártová, V.; Rosíval, I; Kicinková, M; Majerciaková, A; Legáth, Jaroslav

doi:10.1002/(sici)1099-0461(1998)12:4<235::aid-jbt6>3.0.co;2-m

Cited by 10 publications

(3 citation statements)

References 45 publications

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“…Generally, results for the kidney showed fewer changes in antioxidant enzyme activity when compared to the liver. This is in accordance with other authors© findings (28), (29). A possible explanation can be the differences in regulation of expression of these enzymes in the liver and the kidney as many tissues show separate responses to factors that regulate antioxidant enzymes (30).…”

Section: Discussionsupporting

confidence: 93%

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Effect of Sesquiterpene Lactones on Antioxidant Enzymes and Some Drug-Metabolizing Enzymes in Rat Liver and Kidney

Jodynis‐Liebert¹,

Murias²,

Bloszyk³

2000

Planta Med

100

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Previously we have reported that several sesquiterpene lactones isolated from Helenium aromaticum and Telekia speciosa showed pro-oxidative properties and caused glutathione level depletion in rat liver in vivo. In the present study we examined the in vivo effect of these lactones on antioxidant enzyme systems and some drug metabolizing enzymes in the liver and the kidney of rats. We found that the majority of the compounds increased the hepatic activity of glutathione peroxidase (GPx), glutathione reductase (GR), and catalase (CAT), but superoxide dismutase (SOD) activity was distinctly lowered by five lactones. A few of the compounds tested caused a decrease in the hepatic cytochrome P450 content and reduced the activity of NADPH-cytochrome P450 reductase, aminopyrine demethylase, aniline hydroxylase and glutathione-S-transferase. Results for the kidney showed fewer changes in activities of both classes of enzymes when compared to the liver. Not all lactones affected the enzymes under test, the most active were: linifolin, helenalin, mexicanin 1 and telekin. 6 alpha-Hydroxy-2,3-dihydroaromaticin behaved differently towards monooxygenases since it induced the activity of aminopyrine demethylase and aniline hydroxylase.

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Section: Discussionsupporting

confidence: 93%

“…Very few investigations have been concerned with drug-metabolizing assays in the kidneys (29), (31). The authors usually confirm our findings that the response of this enzyme system to any xenobiotic is much weaker in the kidney in comparison with the liver.…”

Section: Discussionsupporting

confidence: 83%

Effect of Sesquiterpene Lactones on Antioxidant Enzymes and Some Drug-Metabolizing Enzymes in Rat Liver and Kidney

Jodynis‐Liebert¹,

Murias²,

Bloszyk³

2000

Planta Med

100

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“…While exposed to the high concentration of toluene (10, 50 and 100 mg kg -1 , respectively), the activity of both CAT and POD exhibited a slight induction, indicating the generation of H 2 O 2 was still within the CAT and POD elimination capacity. It has been reported that the sensitivity of antioxidant enzymes (SOD, CAT and POD) to various oxidative stress varies greatly, indicating that they might respond to oxidative attack in different ways (Holocská et al 1998). The results in our study indicate that the activity of the three antioxidant enzymes had different responses to the toxicities of toluene within the tested concentration of toluene.…”

Section: Discussionmentioning

confidence: 48%

Oxidative stress and DNA damage in the earthworm Eisenia fetida induced by toluene, ethylbenzene and xylene

et al. 2010

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Superoxide dismutase (SOD), guaiacol peroxidase (POD), catalase (CAT), and the comet assay (SCGE) were used as biomarkers to evaluate the oxidative stress and genotoxicity of toluene, ethylbenzene and xylene in earthworms (Eisenia fetida). The results indicated that the exposure of the three pollutants caused a stress response of the three enzymes, an approximate bell-shaped change (a tendency of inducement firstly and then inhibition with increasing concentrations of the pollutants) was mostly found. The three enzymes tested differed in their sensitivity to different pollutants. While the activity of POD was not significantly changed within the concentration range, the concentration thresholds for significant (P < 0.05) responses to toluene based on SOD and CAT were 5 mg kg(-1), respectively. Similarly, the concentration thresholds for significant (P < 0.05) responses to ethylbenzene based on CAT and POD were 10 and 5 mg kg(-1), respectively, while the activity of SOD was not significantly changed within the concentration range. Significant responses to xylene based on CAT and POD were 5 mg kg(-1), respectively, while the activity of SOD was significantly (P < 0.05) induced at 10 mg kg(-1). The SCGE assay results showed that these three pollutants could significantly (P < 0.01) induce DNA damage in earthworms and the clear dose-dependent relationships were displayed, indicating potential genotoxic effects of toluene, ethylbenzene, and xylene on E. fetida. The inducement of DNA damage may be attributed to the oxidative attack of toluene, ethylbenzene, and xylene. Toluene seemed to be more genotoxic as it could induce the higher extent of DNA damage than ethylbenzene and xylene. The results suggest that the SCGE assay of earthworms is simple and efficient for diagnosing the genotoxicity of pollutants in terrestrial environment.

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Oxidants, Antioxidants and Oxidative Stress

Ďuračková

Gvozdjáková²

2008

Mitochondrial Medicine

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Antioxidant and detoxifying enzymes in the liver and kidney of pheasants after intoxication by herbicides MCPA and ANITEN

Cited by 10 publications

References 45 publications

Effect of Sesquiterpene Lactones on Antioxidant Enzymes and Some Drug-Metabolizing Enzymes in Rat Liver and Kidney

Effect of Sesquiterpene Lactones on Antioxidant Enzymes and Some Drug-Metabolizing Enzymes in Rat Liver and Kidney

Oxidative stress and DNA damage in the earthworm Eisenia fetida induced by toluene, ethylbenzene and xylene

Oxidants, Antioxidants and Oxidative Stress

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