Antioxidant and Hepatoprotective Activities of Cirsium setidens NAKAI against CCl₄-Induced Liver Damage

Abstract

The antioxidant activity and hepatoprotective potential of Cirsium setidens Nakai, a widely used medicinal plant, were investigated. The n-butanol (n-BuOH) fraction of leaves and roots of C. setidens had a higher 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity than the other soluble fractions. The n-BuOH fraction of roots of C. setidens had a significant hepatoprotective activity at a dose of 500 mg/kg compared to that of a standard agent. The biochemical results were confirmed by histological observations indicating that C. setidens extract decreased ballooning degeneration in response to CCl(4) treatment. The n-BuOH fraction reduced CCl(4)-induced liver injury in rats, and transcript levels of genes encoding antioxidant enzymes such as glutathione peroxidase 1 (GPO1), glutathione peroxidase 3 (GPO3) and superoxide dismutase (SOD1) were elevated in the livers of rats treated with this fraction (500 mg/kg). Based on these results, we suggest that the C. setidens extract has hepatoprotective effect related to its antioxidant activity.

Hepatoprotective effect of Coreopsis tinctoria flowers against carbon tetrachloride-induced liver damage in mice

“…Liver detoxification occurs in two phases, namely phase I (involving oxidation, reduction, and hydrolysis) and phase II (involving synthetic conjugations with sulfates, glucuronic acid, glutathione, acetate, and glycine), and these phases convert toxic materials into harmless metabolites and then excrete them from the body [7]. Liver diseases are considered serious problems which can be caused by toxic chemicals, drugs, and virus infiltration through ingestion or infection [8]. These toxins induce the production of reactive oxygen species (ROS), which can attack hepatic tissue and cause serious injury [9, 10].…”

Hepatoprotective Effect of Cuscuta campestris Yunck. Whole Plant on Carbon Tetrachloride Induced Chronic Liver Injury in Mice

“…Liver tissue injury can be caused by the ingestion of chemicals or drugs or by infection through virus infiltration [6]. Among them, carbon tetrachloride (CCl 4 ) is commonly used to study hepatotoxicity in animal models [7,8].…”

Chemical Composition of the Essential Oil fromCirsium setidens, a Korean Medicinal Plant

“…The young leaves and stems of C. setidens are edible and rich in nutrients including calcium and vitamin A 5 . It has been reported that Cirsium species including C. setidens contains bioactive phytochemicals with various medicinal activities such as anti-oxidant, anti-cancer, anti-tumor, and anti-inflammatory activities 3,[6][7][8][9][10][11][12][13] . Pectolinarian (C 29 H 34 O 15 ) belong to a group of flavones is reported to be common in the genus Cirsium, and the aglycone of pectolinarian prevents galactosamine-induced hepatic inflammatory activity by inhibiting eicosanoid formation in inflammatory lesions 7,12 .…”