“…Similarly, these herbs are also protective in animal models of radiation injury [128] and chemical toxemia [129], although it is not yet known whether the protective mechanism is dependent on the HMGB1 suppression. In addition, an increasing number of herbal components (e.g., nicotine, EGCG, tanshinone, glycyrrhizin, chlorogenic acid, Emodin-6-O-β-D-glucoside, Rosmarinic acid, isorhamnetin-3-O-galactoside, Persicarin, Forsythoside B, chloroquine, acteroside) [103,130-140] have been proven effective in inhibiting endotoxin-induced HMGB1 release ( Figure 3, Table 2 ).…”