Antioxidant and hepatoprotective effects ofAsparagus albusleaves in carbon tetrachloride-induced liver injury rats

Abstract

The antioxidant and hepatoprotective activities of hot aqueous extract from Asparagus albus (A. albus) leaf against CCl 4 -induced liver damage in rats were investigated. The total phenolic, flavonoid, and condensed tannin contents of hot aqueous extract from A. albus leaf were determined. The antioxidant activity of hot aqueous extract from A. albus leaf was evaluated using the antioxidant capacity, DPPH free radical-scavenging ability and reducing power assays. Different polyphenolic compounds, namely gallic acid, vanillic acid, 3,4 dimethoxybenzoic acid, catechin, rutin, and quercetin were identified. Oral administration of hot aqueous extract from A. albus leaf to male Wistar, intoxicated with CCl 4 , demonstrated a significant protective effect by lowering the levels of hepatic marker enzymes (aspartate and lactate transaminases) and by improving the histological architecture of the rat liver. The hot aqueous extract from A. albus leaf attenuated oxidative stress by restoring the activities of superoxide dismutase, catalase, and glutathione peroxidase.This study demonstrated that the hot aqueous extract from A. albus leaf protects rat liver from CCl 4 -induced injury and suggests a potential therapeutic use for A. albus plant. Practical applicationsThe hepatoprotective effects of plant extracts are mainly related to their richness in phenolic compounds. Phenolic compounds are secondary metabolites widely found in plants, mostly represented by phenolic acids and flavonoids. The growing interest in these bioactive antioxidant components is principally due to their antioxidant potential and the association between their consumption and the prevention of some diseases. In this study, a remarkable hepatoprotective effect of the hot aqueous leaf extract obtained from Asparagus albus was detected against CCl 4 -induced liver injury in rat and its mechanism was related, at least in part, to its free radical scavenging and antioxidant activity on account of the presence of polyphenols.

Phytoconstituents of an ethanolic pod extract of Prosopis cineraria triggers the inhibition of HMG-CoA reductase and the regression of atherosclerotic plaque in hypercholesterolemic rabbits

“…Our results also indicated that LPO (lipid peroxidation) was reduced in rabbits treated with the extract; which again confirms its role in scavenging reactive oxygen species (ROS). It is possible that these effects may be directly due to the free radical scavenging potential of the phytoconstituents in the ethanolic extract [47]. Collectively, results of the present study demonstrate that the phytoconstituents contained in an ethanolic extract of Prosopis cineraria pods inhibits HMG -CoA reductase activity and reduces the level of atherosclerotic plaque in hypercholesterolemic rabbits.…”

The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice

“…Overdose APAP overwhelms the hepatic detoxification process and depletes GSH, which leads to oxidative stress and further contributes to liver injury [28]. Therefore, antioxidants and antioxidant-rich plant may be used as therapeutic agents for liver damage [27, 29, 30]. An increasing body of evidences have proved that alleviating oxidative stress and inflammation would be a potential way to attenuate acute liver injury induced by APAP [31–33].…”

Effect of Curcuma longa Aqueous Extract on Male Fertility in Aluminum Exposed Wistar Rats

“…The filtrate is combined, centrifuged at 4000 rpm for 20 min, the supernatant is concentrated to dryness using a rotary evaporator and the residue is stored at 4 ° C until use. This procedure was repeated weekly throughout the study 22 .…”