Antioxidant and hepatoprotective potentials of ethanol stem bark extract of Daniela oliveri (Rolfe) Hutch and Dalz (Caesalpinaceae)

Sulaimon, Lateef Adegboyega; Obuotor, Efere Martins; Rabiu, Lukman Abubakar; Shehu, Amina Abubakar; Aliyu, Mansur; Shiro, Maryam Qaseem

doi:10.1016/j.synres.2020.100067

Cited by 6 publications

(5 citation statements)

References 38 publications

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“…Ethanolic extract of D. oliveri stem bark has a potent hepatoprotective effect that may be associated to its antioxidant potential and confirm its usage in the traditional management of liver disorders. (Sulaimon et al, 2020).…”

Section: Daniella Oliverimentioning

confidence: 99%

Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds

Thilagavathi

Begum

Varatharaj

et al. 2023

Phytotherapy Research

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Liver problems are a worldwide concern, and conventional medicinal therapies are ineffective. Hence, safeguarding the healthy liver is vital for good health and well‐being. Infections due to virus, immune problems, cancer, alcohol abuse, and an overdose of drugs are some of the causes of liver diseases. Antioxidants derived from medicinal plants and conventional dietary sources can protect the liver from damages caused by oxidative stress system and various chemicals. Plants and plant‐derived phytochemicals are appealing hepatoprotective agents since they have less side effects and still there is a lot of interest shown in using herbal tonics for treating liver disorders. This review therefore primarily focuses on newly discovered medicinal plants and compounds produced from plants that fall under the classifications of flavonoids, alkaloids, terpenoids, polyphenolics, sterols, anthocyanins, and saponin glycosides, all of which have the potential to be hepatoprotective. Hosta plantaginea, Ligusticum chuanxiong, Daniella oliveri, Garcinia mangostana, Solanum melongena, Vaccinium myrtillus, Picrorhiza kurroa, and Citrus medica are some potential plants having hepatoprotective effects. We conclude that these phytochemicals and the plant extracts listed above are used in the future to treat a variety of liver diseases, additional research is still needed to develop safer and more potent phytochemical drugs.

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Section: Daniella Oliverimentioning

confidence: 99%

Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds

Thilagavathi

Begum

Varatharaj

et al. 2023

Phytotherapy Research

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“…and silymarin (100 mg/kg b.w.) reversed the elevated activities of antioxidant enzymes, lipid profiles and other parameters Mali Nigeria Nigeria Nigeria [ 41 ] [ 62 ] [ 63 ] [ 81 ] Stem bark Leaves Stem bark Exudates (Oleiresin) Aqueous Ethanol and fractions (n-hexane, diethyl ether and petroleum ether) Crude (aqueous, aqueous-ethanol, ethanol) and fractions (ethylacetate, ethylether, butanol) Methanol In vitro (DPPH) In vitro (DPPH) In vitro (DPPH) In vitro (DPPH) 20, 40 and 80 μg/ml 1, 3, 5, 10, 20, 30, 50, 100 μg/ml NS 200, 250 μg/ml Showed a good inhibitory (IC 50 14.57 μg/ml) potential though inferior to ascorbic acid (7.39 μg/ml) suggesting a considerable antioxidant activity. Diethyl ether (94.60%) and ethyl acetate (93.06%) fractions showed the highest inhibitions of the DPPH radical indicating good antioxidant effect.…”

Section: Results (Pharmacological and Safety Properties)mentioning

confidence: 99%

“…The emergence of pathological conditions or diseases such as diabetes mellitus, high blood pressure, cardiovascular diseases have been linked to compromised antioxidant defense mechanism [ 81 , 82 ]. Hence, an elevated or boosted defense status through the use of (synthetic) antixodants (such as vitamin C) protect the body from the onset of these illnesses [ 83 ].…”

Section: Results (Pharmacological and Safety Properties)mentioning

confidence: 99%

“…Hence, an elevated or boosted defense status through the use of (synthetic) antixodants (such as vitamin C) protect the body from the onset of these illnesses [ 83 ]. Numerous epidemiological findings have indicated MPs including D. oliveri with antioxidant potential to exhibit (better) protection in the maintenance of health and prevention of diseases [ 41 , 62 , 81 ].…”

Section: Results (Pharmacological and Safety Properties)mentioning

confidence: 99%

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A review of indigenous knowledge and ethnopharmacological significance of African Copaiba Balsam Tree, Daniellia oliveri (Fabaceae)

Balogun,

Ajao,

Sabiu

2023

Heliyon

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“…The result herein is also in correlation with the findings of Kning, et al [28], on the effect of ethanolic extract of roots and seeds of Daniellia oliveri on thiol and lipid peroxidation in rats treated with cadmium. [29] reported the DPPH radical scavenging activity as well as the ability of stem bark ethanolic extract of Daniellia oliveri to increase the level of antioxidant enzymes in the body. Noteworthy is the fact that the antioxidant activity of flavonoids and phenolic compounds depends largely on the presence of free OH groups [30].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study on GC-MS Profiles and Effect of Ethanolic Extracts of Stem-Bark and Leaves of Daniellia oliveri on Cerebral Sodium Pump and Thiols Status in Fenton Reaction Treated Rat Organs In-vitro

Ale

Asuelimen

Ayo

et al. 2023

AJRB

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Daniellia oliveri is one of the most extensively utilized medicinal plants in Nigeria and some West African countries for the treatment of various ailments. In the present study, the GC-MS profiles and effect of ethanolic extracts of stem bark and leaves of Daniellia oliveri on lipid peroxidation, Na+/K+-ATPase activity and thiols status in H2O2 and Fe2+ (fenton reaction) assaulted cerebral and hepatic tissue homogenates was investigated. The stem bark and leaves were extracted with absolute ethanol for 72hrs and concentrated in a rotary evaporator. Wistar rats were euthanized and the brains and livers were removed, homogenized, centrifuged and the supernatants were used for lipid peroxidation, Na+/K+-ATPase activity, and thiol assays in the presence of prooxidants (1mM H2O2 or 10μM Fe2+ or H2O2 and Fe2+).The results revealed that ethanol extract of both the leaf and stem-bark inhibited lipid peroxidation induced by H2O2, Fe2+ and combination of H2O2 and Fe2+ and this was evident in the reduction of lipid peroxidation adducts formation in rat liver and brain homogenates with the stem-bark possessing more efficacy. Furthermore, the results of Na+/K+-ATPase and thiol assays revealed that H2O2 and Fe2+ inhibited the activity of cerebral Na+/K+-ATPase, while H2O2/Fe2+ caused a marked reduction in the levels of both protein and non-protein thiols in the tissues homogenates. However, the ethanolic extract of Daniellia oliveri extirpated this anomaly by increasing the activity of cerebral Na+/K+-ATPase as well as the thiol level in the rat hepatic and cerebral tissues. Finally, GC-MS analysis was carried out on the ethanolic extracts of the stem bark and leaves of Daniellia oliveri and results revealed the presence of 21 compounds including 1,2-Benzisothiazol-3-amine, 1H-Indole-2-carboxylic acid, 2-Ethylacridine, Ethyl 2-(2-chloroacetamido)-3,3,3-trifluoro-2-(3-fluoroanilino) propionate and trans-1-Butyl-2-methylcyclopropane in the stem bark and 10 compounds including Methylthio-acetonitrile, 2-Methyl-Z,Z-3,13-octadecadienol, Desulphosinigrin and 4H-1,2,4-triazole-3,5-diamine in the leaves, justifying the observed biological activities of Daniellia oliveri and the higher potency of the stem bark may be attributed to the presence of more bioactive constituents found in it. This study therefore justifies the medicinal usage of leaves and stem-bark of Daniellia oliveri and suggests its consideration in the treatment and management of degeneration diseases with etiology associated with oxidative stress.

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Antioxidant and hepatoprotective potentials of ethanol stem bark extract of Daniela oliveri (Rolfe) Hutch and Dalz (Caesalpinaceae)

Cited by 6 publications

References 38 publications

Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds

Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds

A review of indigenous knowledge and ethnopharmacological significance of African Copaiba Balsam Tree, Daniellia oliveri (Fabaceae)

A Comparative Study on GC-MS Profiles and Effect of Ethanolic Extracts of Stem-Bark and Leaves of Daniellia oliveri on Cerebral Sodium Pump and Thiols Status in Fenton Reaction Treated Rat Organs In-vitro

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