Antioxidant and hepatoprotective role of selenium against silver nanoparticles

Ansar, Sabah; Alshehri, Saad M.; Abudawood, Manal; Hamed, Sherifa S.; Ahamad, Tansir

doi:10.2147/ijn.s136748

Cited by 54 publications

(34 citation statements)

References 67 publications

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“…These results indicated that the administration of 0.5 or 1.0 mg AgNPs/kg BW did not induce the oxidative stress in rabbits under heat stress conditions. However, administration of higher doses of AgNPs (5 mg/kg/day) induced hepatic damage and oxidative stress illustrated by a significant decrease in total antioxidant capacity level and the activities of GSH-Px and superoxide dismutase in rats [35]. The decreased levels of GSH-Px due to the injection of AgNPs might be attributed to the high affinity of nanoparticles for thiol groups leading to a decrease in glutathione content due to the free radical scavenging [36].…”

Section: Discussionmentioning

confidence: 99%

Effect of Silver Nanoparticle Administration on Productive Performance, Blood Parameters, Antioxidative Status, and Silver Residues in Growing Rabbits under Hot Climate

Abdelsalam

Al-Homidan

Ebeid

et al. 2019

Animals

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Simple SummarySilver nanoparticles (AgNPs) were used for their antibacterial effects, which increase productive performance and immune response in poultry and rabbits. On the other hand, residues of silver in meat and the internal organs of treated animals may be toxic for human beings. The current results of using two doses of injecting AgNPs revealed that body weight significantly improved in rabbits given a low dose of AgNPs compared with control animals. For consumers’ health concerns, it is of interest to note that the amount of accumulated silver in blood plasma and meat increased dramatically with an increasing dose.AbstractThe influence of subcutaneous injections of silver nanoparticles (AgNPs) on rabbit performance, hematological and biochemical parameters of blood, antioxidant status, and the residues of silver in meat and blood in two breeds (New Zealand White (NZW) and Jabali) of rabbits growing under high ambient temperature was evaluated. A total of 90 six-week-old rabbits (45 NZW and 45 Jabali) were randomly distributed into three equal treatment groups (control, 0.5 mg, and 1.0 mg AgNPs/kg body weight). The treated rabbits were injected twice a week for four consecutive weeks. The results revealed that AgNPs administration had no significant effect on average daily gain (ADG), feed intake, and feed conversion ratio (FCR). The NZW breed surpassed the Jabali breed in growth performance traits, carcass weight, dressing percentage, and cuts of mid parts and hind cuts. Administration of AgNPs had a significant effect on hematocrit (HCT) and platelet (PLT) values. Rabbits injected with AgNPs at a dose of 0.5 mg showed a lower plasma concentration of total cholesterol and triglycerides than that of control rabbits. The NZW breed had significantly low platelet, total cholesterol, and triglyceride values. Rabbits injected with 0.5 mg/kg BW had the lowest total antioxidant capacity and highest malondialdehyde (MDA) and glutathione peroxidase. The Ag residues were higher in blood than those in meat in treated rabbits. The local breed (Jabali) had significantly lower residues than the imported one (NZW) either in meat or in blood. However, the amount of accumulated silver in blood plasma and meat increased with increasing dose.

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Section: Discussionmentioning

confidence: 99%

Effect of Silver Nanoparticle Administration on Productive Performance, Blood Parameters, Antioxidative Status, and Silver Residues in Growing Rabbits under Hot Climate

Abdelsalam

Al-Homidan

Ebeid

et al. 2019

Animals

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“…Conversely, rats co-treated with Sel demonstrably ameliorate DCF-induced hepatic injury dose-dependently, evaluated by transaminases levels in serum. 48,49 Renal function marker enzymes such as urea and creatinine are metabolic waste products primarily excreted in the urine. They are important in the diagnosis of kidney injury.…”

Section: Discussionmentioning

confidence: 99%

“…22 However, increased (p < 0.05) SOD, CAT, GST GPx activities in Sel and DCF co-treated rats showed the protective augmentation of Sel against DCF-induced oxidative stress via enhancement of antioxidant enzymes activities in line with previous findings. 48,[52][53][54] GSH acts as a cofactor of several detoxifying enzymes (e.g. GPx, GST), scavenging intracellular free radicals.…”

Section: Discussionmentioning

confidence: 99%

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Biochemical alterations in diclofenac-treated rats: Effect of selenium on oxidative stress, inflammation, and hematological changes

Owumi

Dim

2019

Toxicology Research and Application

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We investigated the effect of selenium (Sel), a trace element in diclofenac sodium (DCF), nonsteroidal anti-inflammatory drugs-induced hepatic and renal toxicities in adult rats. Five experimental groups namely control, DCF (10 mg/kg), Sel (0.125 mg/kg), DCF + Sel (0.125 mg/kg), and DCF + Sel (0.25 mg/kg) consisting of 10 rats each were orally treated for 7 consecutive days. Following killing, biomarkers of hepatic and renal toxicities, antioxidant enzyme levels, myeloperoxidase activity, nitric oxide levels, reactive oxygen and nitrogen species (RONS), and lipid peroxidation (LPO) were analyzed spectrophotometrically. Further, the concentration of tumor necrosis factor alpha (TNF-α) was assessed using enzyme-linked immunosorbent assay, and hematological indices: white blood cells (WBC), lymphocytes, and neutrophils and eosinophil counts. Results indicated that DCF-induced increases in biomarkers of hepatic and renal toxicity were significantly ( p < 0.05) lessened in serum of rats co-exposed to DCF and Sel in a dose-dependent manner. DCF mediated decrease in antioxidant status, and increases in RONS, LPO, and TNF-α levels were reduced ( p < 0.05) in the liver and kidney of rats co-exposed to DCF and Sel. Additionally, Sel reduced hematological abnormalities associated with DCF treatment. Light microscopic examination showed that the severity of histopathological lesions induced by DCF was lessened in rats co-exposed to DCF and Sel. Taken together, Sel supplementation mitigated DCF-induced oxidative stress, inflammation, and hematological abnormalities in the liver and kidney of treated rats.

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“…These structural impairments may explain why cardiac hemodynamic parameters were affected and cardiac functions were reduced in AgNPs-exposed animals. Although there have been studies reported that selenium alleviates heavy metal and silver induced toxicity in cells and tissues, 23 , 38 – 40 there has been no study examining the detoxifying effect of sodium selenite on AgNPs-induced toxicity in cardiac tissue. The results from this study clearly demonstrated that treatment with selenite reduced the disarray of sarcomere and fragmentation of myofibrils, and improved capillary patency in AgNPs-exposed rats, suggesting that selenium supplementation is capable of correcting AgNPs toxicity in the heart.…”

Section: Discussionmentioning

confidence: 99%

<p>Ameliorative Effect of Sodium Selenite on Silver Nanoparticles-Induced Myocardiocyte Structural Alterations in Rats</p>

Ma¹,

He²,

Xu³

et al. 2020

IJN

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Background The application of silver nanoparticles (AgNPs) is growing exponentially, and its potential damage to the cardiac remains to be elucidated. The purpose of this study was to investigate the ameliorative effect of sodium selenite on silver nanoparticles-induced myocardiocyte structural alterations in rats. Materials and Methods Forty male Sprague-Dawley (SD) rats were randomly divided into four groups: control group, AgNPs group, Se control group, and AgNPs + Se group. SD rats were administered AgNPs through a single intratracheal instillation, and sodium selenite was given by intraperitoneal injection for seven days. Cardiac function was determined by echocardiography and hemodynamic, ultrastructural changes by transmission electron microscopy examination. Mitochondrial fission and autophagy markers were measured by Western blotting. Results AgNPs caused a significant decrease in cardiac contraction, diastolic dysfunction, fragmentation, and lysis of the myofibrils, the formation of stenosis in the capillary, damaging the mitochondria membrane and cristae. AgNPs significantly increased mitochondrial fission markers dynamin-related protein 1 (Drp1), phospho-Drp1 (p-Drp1), and mitochondrial fission protein 1 (Fis1), as well as autophagy marker LC3 II/I ( P <0.05). Treatment with sodium selenite is capable of protecting cardiac function from AgNPs toxicity through attenuating ultrastructural alterations, stabilizing mitochondrial dynamic balance and blocking mitochondrial autophagy. Conclusion We conclude that the protection of sodium selenite against silver nanoparticles-induced myocardiocyte structural alterations is associated with stabilizing mitochondrial dynamic balance and mitophagy.

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Antioxidant and hepatoprotective role of selenium against silver nanoparticles

Cited by 54 publications

References 67 publications

Effect of Silver Nanoparticle Administration on Productive Performance, Blood Parameters, Antioxidative Status, and Silver Residues in Growing Rabbits under Hot Climate

Effect of Silver Nanoparticle Administration on Productive Performance, Blood Parameters, Antioxidative Status, and Silver Residues in Growing Rabbits under Hot Climate

Biochemical alterations in diclofenac-treated rats: Effect of selenium on oxidative stress, inflammation, and hematological changes

<p>Ameliorative Effect of Sodium Selenite on Silver Nanoparticles-Induced Myocardiocyte Structural Alterations in Rats</p>

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