Antioxidant and immune-enhancing potentials of leaf extract and active constituents of Millettia aboensis

Ajaghaku, DL; Akah, P. A.; Ilodigwe, EE; Umeokoli, BO; Nworu, CS; Okoye, FB

doi:10.1055/s-0035-1565574

Cited by 4 publications

(4 citation statements)

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“…The free radical scavenging activity of the plant extracts and fractions was evaluated using the method of Ajaghaku et al (2017).…”

Section: Dpph Activity Testmentioning

confidence: 99%

Effect of phytoestrogen-rich fraction of Millettia aboensis on lipid profile, oxidative stress, and platelet count in ovariectomized rat model of menopause

Anwuchaepe Ajaghaku,

Ajaghaku,

Onyegbule

et al. 2023

ijpbp

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Milletia aboensis has long-standing ethnopharmacological indications for the treatment of symptoms and diseases related to menopause. This investigation examined the effects of its phytoestrogen-rich fraction on some predictors of cardiovascular risk in an ovariectomized rat model of menopause. In vitro, antioxidant activity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) test. Ovariectomy was used to trigger menopause by surgically removing the ovaries under anesthesia. After recovery, the animals were treated orally with the phytoestrogen-rich fraction (PERF) of M. aboensis daily for 30 days. Blood samples were obtained for the estimation of serum lipid profile, antioxidant enzyme activities, lipid peroxidation, and platelet count. The PERF showed the strongest inhibition of DPPH radical with an IC50 value of 19.65 µg/ml. At 200 and 400 mg/kg, the PERF dose-dependently showed significant increase in high-density lipoprotein (HDL) (42.86 and 43.05 mg/dl) and a significant (p < 0.05) decrease in low-density lipoprotein (LDL) levels (3.78 and 1.24 mg/dl) compared with the ovariectomized (OVX) control (31.82 and 20.32 mg/dl, respectively). Being dose-dependently, the PERF increased catalase (CAT) and superoxide dismutase (SOD) enzyme activities as well as significantly reduced malondialdehyde (MDA) levels compared to OVX control. At 200 and 400 mg/kg, the PERF restored platelet count with values (316.54 and 343.3 103/IU, respectively) close to that of sham-operated control (365.17 103/IU). The ability of M. aboensis to reverse lipid abnormalities associated with ovariectomy coupled with its reduced platelet count, and antioxidant effects make it a potential therapeutic phytoestrogen remedy for the management of cardiovascular complications associated with estrogen deficiency.

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“…The free radical scavenging activity of the plant extracts and fractions was evaluated using the method of Ajaghaku et al (2017).…”

Section: Dpph Activity Testmentioning

confidence: 99%

Effect of phytoestrogen-rich fraction of Millettia aboensis on lipid profile, oxidative stress, and platelet count in ovariectomized rat model of menopause

Anwuchaepe Ajaghaku,

Ajaghaku,

Onyegbule

et al. 2023

ijpbp

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“…Bioactivity-directed isolation led to the discovery of rutin ( Figure 12 , quercetin-3- O -rutinoside). Compared to the DMSO control group, the rutin treatment of lymphocytes increased the population of CD4+ lymphocytes and promoted the secretion of IFN-γ [ 104 ].…”

Section: Natural Products That Enhance Immunitymentioning

confidence: 99%

Development of Broad-Spectrum Antiviral Agents—Inspiration from Immunomodulatory Natural Products

Zhang

Xiong

Song

et al. 2021

Viruses

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Developing broad-spectrum antiviral drugs remains an important issue as viral infections continue to threaten public health. Host-directed therapy is a method that focuses on potential targets in host cells or the body, instead of viral proteins. Its antiviral effects are achieved by disturbing the life cycles of pathogens or modulating immunity. In this review, we focus on the development of broad-spectrum antiviral drugs that enhance the immune response. Some natural products present antiviral effects mediated by enhancing immunity, and their structures and mechanisms are summarized here. Natural products with immunomodulatory effects are also discussed, although their antiviral effects remain unknown. Given the power of immunity and the feasibility of host-directed therapy, we argue that both of these categories of natural products provide clues that may be beneficial for the discovery of broad-spectrum antiviral drugs.

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“…Furthermore, the chronic neurological damage is due to the accumulation of lipid peroxidative products leads to damage to the neurological system leads to produce the stroke symptom [93,94]. The free radical and LPO are well documented to produce neurodegeneration in stroke condition [95]. However, the tested compounds are show in the alteration of LPO products in the neurological system.…”

Section: Role Of Lpo In Strokementioning

confidence: 99%

“…Catechin isolated from A. senegalensis had effective DPPH inhibition (IC 50 0.03 mgmL −1 ) and Fe 2+ chelating activity (1.29 mgmL −1 ) when compared to ascorbic acid (0.01 mgmL −1 ) and EDTA (IC 50 0.05 mgmL −1 ) respectively[94]. The evaluation on H 2 O 2 inhibition by (−)-epicatechin isolated from A. floribunda showed effective activity with equal strength as standard ascorbic acid (IC 50 8.0 μgmL −1 )[95]. Similarly, the…”

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confidence: 99%

Lipid Peroxidation Research

Mansour¹

2020

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As a fellow, he has contributed significantly to defining some aspects of the molecular biology of tissue injury and induction of liver and renal toxicity, with particular focus on the role of antioxidants in the prevention and treatment of different toxic effects. In addition, he has contributed notably to developing a new strategy for tumors especially in the liver. His research has shown that the proteasome inhibitor plays an important role in preventing carcinogenesis of the liver by metastatic tumors. He then moved to King Saud bin Abdulaziz University for Health Science, where he continued to work on the pathogenesis of cancer and on issues concerning the cellular and molecular mechanisms of cancer biology and the metastatic process. He is now conducting studies on liver cancer using gankyrin.

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Antioxidant and immune-enhancing potentials of leaf extract and active constituents of Millettia aboensis

Cited by 4 publications

References 0 publications

Effect of phytoestrogen-rich fraction of Millettia aboensis on lipid profile, oxidative stress, and platelet count in ovariectomized rat model of menopause

Effect of phytoestrogen-rich fraction of Millettia aboensis on lipid profile, oxidative stress, and platelet count in ovariectomized rat model of menopause

Development of Broad-Spectrum Antiviral Agents—Inspiration from Immunomodulatory Natural Products

Lipid Peroxidation Research

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