Antioxidant and Immunomodulant Effect of Hepatoprotective Drugs

Fehér, János; Cornides, A.; Csomós, Géza

doi:10.1007/978-3-642-72631-6_33

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…However, after treatment with ethanolic extract of C. ferruginea and silymarin, there was a decrease in the level of total serum bilirubin in CCL4-induced rats. This agrees with the report of Feher et al (1987) who reported that silymarin can reduce the elevated level of total bilirubin caused by hepatic injury. For C. ferruginea, this could be due to its antioxidant activity (Okoro, 2020b;Ita, 2017).…”

Section: Okoro E Osupporting

confidence: 93%

Hepatoprotective Effect of Ethanolic Extract of Cnestis ferruginea Roots on Carbon tetrachloride-Induced Liver Damage in Male Rats

Okoro

2024

jasem

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Hepatoprotection or antihepatotoxicity is the ability of an agent or chemical to prevent damage to the liver. These hepatoprotective agents mitigate the liver injury caused by the hepatotoxic agents. Therefore, the objective of this paper was to investigate the hepatoprotective effect of ethanolic extract of Cnestis ferruginea roots on carbon tetrachloride (CCl4)-induced liver damage in male rats using appropriate standard methods. A single dose of CCl4 administration significantly (p<0.05) increased the levels of ALT and AST in the positive control group, compared to the negative control group. Also, a significant (p<0.05) increase in the level of ALP and TB was seen in the positive control group relative to the negative control group. While, pre-treatment with either the extract or the standard drug significantly (p<0.05) reduced the levels of hepatic enzymes of serum (ALT, AST and ALP) and TB, when compared with the positive control group. Similarly, the activity of Glutathione-s-transferase (GST), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in the liver of untreated rats (induced with CCl4)was significantly decreased (p<0.05) in comparison with the rats treated with the extracts and the standard drug. Thus, treatment of the CCl4 -induced rats with the extracts for fourteen days resulted in the reversal of the CCl4- induced liver damage in the rats with the high dose (200 mg/kg) giving the best result which was comparable with the standard drug. Therefore the ethanolic extract of C. ferruginea roots protects the liver against CCl4 -induced oxidative stress.

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Section: Okoro E Osupporting

confidence: 93%

Hepatoprotective Effect of Ethanolic Extract of Cnestis ferruginea Roots on Carbon tetrachloride-Induced Liver Damage in Male Rats

Okoro

2024

jasem

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Hepatoprotective effects of Allium cepa (onion) extracts against paracetamol-induced liver damage in rats

Ozougwu¹,

Eyo²

2014

Afr. J. Biotechnol.

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Liver damage due to paracetamol hepatotoxicity is a major health challenge worldwide. It is against this background that this study was designed to determine the hepatoprotective effects of the increasing dosage of Allium cepa methanolic extracts on paracetamol induced hepatotoxic rats. Fifty-four (54) adult male albino rats comprising of nine normal and 45 paracetamol hepatotoxic rats were used for this study. The experimental design was the three by three Latin square design. Paracetamol hepatotoxicity was induced by single administration of paracetamol at 750 mg/kg ip on the first day of the experiment. The different biochemical parameters assessed were determined before the start of the study and subsequently monthly for the duration of the study. Blood samples were collected from the rat through the eye monthly for analysis and serum was obtained by centrifugation (5000 rpm for 10 min) and stored at-20°C prior to analysis. The effects of duration and increasing dosages (200, 300 and 450 mg/kg) of A. cepa methanolic extracts produced a duration dependent significant (p < 0.05) reductions in the alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and total serum bilirubin (TSB) of paracetamol hepatotoxic rats after the duration of study when compared with those of the paracetamol, normal and silymarin control rats. A. cepa reduced alanine aminotransferase and total serum bilirubin in a dose dependent fashion whereas it reduced aspartate aminotransferase, alkaline phosphatase and lactate dehydrogenase level in a dose independent manner. A. cepa extracts studied showed potent hepatoprotective properties. It was evident that A. cepa extracts was able to reduce significantly all the elevated biochemical parameters due to paracetamol hepatotoxicity and this was collaborated by results of histopathological studies.

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Antioxidant and Immunomodulant Effect of Hepatoprotective Drugs

Cited by 2 publications

References 5 publications

Hepatoprotective Effect of Ethanolic Extract of Cnestis ferruginea Roots on Carbon tetrachloride-Induced Liver Damage in Male Rats

Hepatoprotective Effect of Ethanolic Extract of Cnestis ferruginea Roots on Carbon tetrachloride-Induced Liver Damage in Male Rats

Hepatoprotective effects of Allium cepa (onion) extracts against paracetamol-induced liver damage in rats

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