Antioxidant and Infertility

Shakir, Huda Mahmood

doi:10.5772/intechopen.95791

Cited by 3 publications

(2 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A deeper comprehension of these enzymes' roles could elucidate the pathomechanisms of various reproductive ailments and potentially pave the way for innovative therapeutic interventions. 44 Non-enzymatic antioxidants The female reproductive system consists of specialized organs and functions designed to support conception, pregnancy, and childbirth. This system can be affected by OS from environmental sources, natural bodily reactions, or metabolic waste products.…”

Section: Glutathione Peroxidase (Gpx)mentioning

confidence: 99%

Oxidative and nitrosative stress and female reproduction: Roles of oxidants and antioxidants

Dutta,

Sengupta,

Izuka

et al. 2024

JIST

View full text Add to dashboard Cite

Oxidative stress (OS), caused by an imbalance between oxidants and antioxidants in the body, is pivotal in influencing female reproductive health. This review explores the complex interactions of oxidizing agents and antioxidants on female reproductive functions, underscoring their impact on fertility, pregnancy, and reproductive outcomes. Primarily resulting from excessive reactive oxygen species (ROS), OS can detrimentally affect oocyte maturation, embryonic development, and endometrial receptivity. Although ROS naturally arise during cell metabolism, their overproduction or insufficient neutralization can damage cellular macromolecules, including lipids, proteins, and DNA. Such disruptions can lead to ovarian issues, recurrent pregnancy losses, and conditions like endometriosis and polycystic ovary syndrome (PCOS). Conversely, antioxidants combat excess ROS, promoting cellular balance and reproductive success. Emerging treatments underscore the benefits of boosting antioxidant levels to address OSrelated disorders. However, caution is essential due to potential risks of excessive antioxidant intake. The review underscores the critical association between OS and female reproduction, suggesting therapeutic strategies for improved reproductive outcomes.

show abstract

Section: Glutathione Peroxidase (Gpx)mentioning

confidence: 99%

Oxidative and nitrosative stress and female reproduction: Roles of oxidants and antioxidants

Dutta,

Sengupta,

Izuka

et al. 2024

JIST

View full text Add to dashboard Cite

show abstract

“…Many previous studies had shown that oxidative stress plays an important role in human fertility. Elevated concentrations of reactive oxygen species (ROS) may have detrimental effects on the spermatozoa, oocytes, sperm oocyte interaction and embryos both in the Fallopian tube and the peritoneal cavity leading to infertility (Mahmood et al, 2021). "Female corrective" is a poly-herbal medicine formulation that is used in the southeastern part of Nigeria for the treatment of women infertility.…”

Section: Introductionmentioning

confidence: 99%

Investigation Of Pro-fertility Actions Of “Female Corrective” Poly-herbal Medicine Formulation Using Female Wister Rat Model

Oraekei,

MBAGWU,

Anaekwe

2023

jcbr

View full text Add to dashboard Cite

Plants contain numerous phytochemical compounds that may be used to cure or prevent diseases. In this study, the pro-fertility actions of “Female corrective” poly-herbal formulation were investigated using female Wister rat model. Phytochemicals, acute toxicities, body weight changes, and antioxidant and female reproductive hormonal studies were carried out. Serum levels of glutathione, superoxide dismutase and catalase were also evaluated. Micro well experiment was used to study the impact of the poly-herbal formulation on reproductive hormones. The phytochemical compounds present in the “Female corrective” were glycosides, saponins, tannins, flavonoids, steroids and terpenoids. In the median lethal dose estimation, no mortality nor obvious signs of toxicity were recorded at the dose of 88 mg/kg body weight. At a concentration of 4.4 mg/mL the body weights of the rats were increased in a dose dependent manner; 2.06, 4.11 and 8.22 mL/kg body weight gave changes in body weights of 17.13, 20.00 and 22.44% respectively after 14 days. Antioxidant effects were recorded as increase in serum concentration of glutathione, superoxide dismutase and catalase. Also, the serum levels of follicle stimulating hormone and luteinizing hormone were increased significantly (p ˂ 0.05) and dose dependently; at the same administered doses, serum levels of follicle stimulating hormone were 3.06 ± 0.06, 4.61 ± 0.05 and 5.25 ± 0.09 mIU/mL respectively and that of luteinizing hormone were 1.02 ± 0.10, 1.71 ± 0.23 and 2.08 ± 0.20 mIU/mL respectively. The possible mechanisms of the herbal drug formulation might include antioxidant as well as pro-gonadotropin activities

show abstract

Antioxidant Strategies to Improve Female Reproduction

Hussain¹

2023

Biochemistry

View full text Add to dashboard Cite

Animals are only productive once their reproductive cycle is continuously flown. There are several causes of stresses which interrupt animal physiology and make animal less productive. All factors involved in stress could eventually generate reactive oxygen species (ROS). Limited production of these reactive species performs several functions to maintain redox homeostasis. When these reactive oxidative metabolites are overwhelmed, it may generate oxidative stress. Disruption in oxidant/antioxidant mechanism leads to cause oxidative stress. Naturally, the body system is equipped with an antioxidant defense system. Once this system is broken-down due to the overproduction of ROS, it may have a detrimental effect on lipids, proteins, DNA, and carbohydrates and eventually influence animal fertility and productivity. Antioxidants available in nature are of two types: natural and synthetic. These compounds endowed several properties in the mitigation of various animal stresses, starting from physiology to molecular level. This chapter elucidates oxidative stress, natural and synthetic antioxidants, and particular focus are emphasized that how antioxidant supplementation can help to improve animal fertility and productivity. Moreover, the mechanism by which antioxidants produce fruitful effects will also be highlighted.

show abstract

Antioxidant and Infertility

Cited by 3 publications

References 49 publications

Oxidative and nitrosative stress and female reproduction: Roles of oxidants and antioxidants

Oxidative and nitrosative stress and female reproduction: Roles of oxidants and antioxidants

Investigation Of Pro-fertility Actions Of “Female Corrective” Poly-herbal Medicine Formulation Using Female Wister Rat Model

Antioxidant Strategies to Improve Female Reproduction

Contact Info

Product

Resources

About