Antioxidant and Inhibitory Effects of Opuntia ficus-indica var. saboten (Cactus) Fruit Extract on Melanin Accumulation in B16F10 Cells

Hwang, Su-Hyeon; Kim, Gyo-Nam

doi:10.17495/easdl.2023.8.33.4.284

easdl

2023

DOI: 10.17495/easdl.2023.8.33.4.284

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Antioxidant and Inhibitory Effects of Opuntia ficus-indica var. saboten (Cactus) Fruit Extract on Melanin Accumulation in B16F10 Cells

Su-Hyeon Hwang,

Gyo-Nam Kim

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2024

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Whitening effect of extract from Engelhardia spicata Lechen ex Blume of native plant in Vietnam

Kim,

Park,

Bach

et al. 2024

JABC

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The aim of the current study was to investigate the whitening effect of extracts from 11 native plants in Vietnam for use as natural materials in cosmeceuticals. Firstly, tyrosinase inhibitory effect was evaluated to investigate the whitening effect of 11 plant extracts. As a result, Engelhardia spicata Lechen ex Blume extract (ESE) has shown the highest tyrosinase inhibitory effect. Therefore, ESE was used for subsequent experiments to clarify the whitening effect and its underlying mechanisms. ESE inhibited tyrosinase activity in a dose-dependent manner and the IC 50 value of ESE against tyrosinase was 99 μg/mL. In addition, ESE significantly inhibited tyrosinase activity and reduced melanin contents dose-dependently in 3-isobutyl-1-methylaxanthine (IBMX)stimulated B16F10 melanoma cells. ESE also downregulated the expression levels of key melanogenic proteins such as microphthalmia-associated transcription factor, tyrosinase-related protein 1, and tyrosinase in IBMX-stimulated B16F10 melanoma cells. In conclusion, these results firstly elucidate the antimelanogenesis effect of ESE in IBMX-induced melanoma cells. Taken together, our results demonstrate that ESE effectively inhibit melanogenesis, and could be applied in the fields of cosmeceuticals as a natural skin-whitening agent.

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Whitening effect of extract from Engelhardia spicata Lechen ex Blume of native plant in Vietnam

Kim,

Park,

Bach

et al. 2024

JABC

View full text Add to dashboard Cite

show abstract

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Antioxidant and Inhibitory Effects of Opuntia ficus-indica var. saboten (Cactus) Fruit Extract on Melanin Accumulation in B16F10 Cells

Cited by 1 publication

References 21 publications

Whitening effect of extract from Engelhardia spicata Lechen ex Blume of native plant in Vietnam

Whitening effect of extract from Engelhardia spicata Lechen ex Blume of native plant in Vietnam

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