1993
DOI: 10.1016/0006-2952(93)90371-3
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Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures

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Cited by 587 publications
(291 citation statements)
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“…Other studies suggest that polyphenols might inhibit free radical formation and the propagation of free radical reactions through the chelation of transition-metal ions, particularly those of iron and copper [11][12][13][14][15][16]. Many studies have demonstrated the antioxidant effects of quercetin in lipid systems in the presence of a range of pro-oxidants [9,17,18].…”
Section: Figure 1 Structural Features Of Flavones and Flavonolsmentioning
confidence: 99%
“…Other studies suggest that polyphenols might inhibit free radical formation and the propagation of free radical reactions through the chelation of transition-metal ions, particularly those of iron and copper [11][12][13][14][15][16]. Many studies have demonstrated the antioxidant effects of quercetin in lipid systems in the presence of a range of pro-oxidants [9,17,18].…”
Section: Figure 1 Structural Features Of Flavones and Flavonolsmentioning
confidence: 99%
“…Extensive in vitro studies have found most of the main dietary¯avonoids to be effective in protecting against the oxidative modi®cation of LDL (de-Whalley et al, 1990;Laughton et al, 1991;Morel et al, 1993;Rankin et al, 1993;Igarashi & Ohmuma, 1995;Fuhrman et al, 1995). The ability of quercetin, and the quercetin glycosides, to protect LDL against oxidative modi®cation has been extensively studied, in every case showing a signi®cant protective effect (de-Whalley et al, 1990;McAnlis et al, 1997).…”
Section: Introductionmentioning
confidence: 99%
“…Transition metals such as iron and copper are important pro-oxidants; some¯avo-noids can chelate divalent metal ions, hence preventing free radical formation (de-Whalley et al, 1990). Extensive in vitro studies have found most of the main dietary¯avo-noids to be effective in protecting against the oxidative modi®cation of LDL (de-Whalley et al, 1990;Laughton et al, 1991;Morel et al, 1993;Rankin et al, 1993;Igarashi & Ohmuma, 1995;Fuhrman et al, 1995). Speci®cally, the ability of tea catechins to protect LDL against oxidative modi®cation has been investigated, with (7)-epigallocatechin (EGC), ( )-catechin (C), (7)-epicatechin (EC), (7)-epicatechingallate (ECG) and (7)-epigallocatechingallate (EGCG) all having a signi®cantly protective effect (NegreSalvayre et al, 1991).…”
Section: Introductionmentioning
confidence: 99%