Antioxidant and Prooxidant Role of β-Carotene in Murine Normal and Tumor Thymocytes: Effects of Oxygen Partial Pressure

Palozza, Paola; Luberto, Chiara; Calviello, Gabriella; Ricci, Paola; Bartoli, Gianna Maria

doi:10.1016/s0891-5849(96)00498-4

Cited by 118 publications

(35 citation statements)

References 33 publications

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“…For example, carotenoids can protect cells against oxidant-induced lipid peroxidation in a pro-vitamin A-independent fashion (275). In transformed thymocytes, carotenoids act as potent antioxidants when oxygen tension is low, but turn into pro-oxidants when oxygen tension is high (324). In addition, supraphysiological concentrations of carotenoids may result in prooxidative effects (145).…”

Section: Carotenoidsmentioning

confidence: 99%

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Massaad

Klann

2011

Antioxidants & Redox Signaling

493

350

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The brain is a metabolically active organ exhibiting high oxygen consumption and robust production of reactive oxygen species (ROS). The large amounts of ROS are kept in check by an elaborate network of antioxidants, which sometimes fail and lead to neuronal oxidative stress. Thus, ROS are typically categorized as neurotoxic molecules and typically exert their detrimental effects via oxidation of essential macromolecules such as enzymes and cytoskeletal proteins. Most importantly, excessive ROS are associated with decreased performance in cognitive function. However, at physiological concentrations, ROS are involved in functional changes necessary for synaptic plasticity and hence, for normal cognitive function. The fine line of role reversal of ROS from good molecules to bad molecules is far from being fully understood. This review focuses on identifying the multiple sources of ROS in the mammalian nervous system and on presenting evidence for the critical and essential role of ROS in synaptic plasticity and memory. The review also shows that the inability to restrain either age-or pathology-related increases in ROS levels leads to opposite, detrimental effects that are involved in impairments in synaptic plasticity and memory function.

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Section: Carotenoidsmentioning

confidence: 99%

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Massaad

Klann

2011

Antioxidants & Redox Signaling

493

350

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“…Moreover, carotenoids induce dose-dependent changes in the activities of antioxidant enzymes in chicken embryo fibroblasts O'Brien 1995 and. Finally, a loss of endogenous ␣-tocopherol was observed in murine thymoma cells after ␤-carotene treatment (Palozza et al 1997b).…”

mentioning

confidence: 92%

Canthaxanthin Supplementation Alters Antioxidant Enzymes and Iron Concentration in Liver of Balb/c Mice

Palozza

Calviello

Leo

et al. 2000

The Journal of Nutrition

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The 4,4Ј-diketo-␤-carotene, canthaxanthin, alters tocopherol status when fed to Balb/c mice, suggesting an involvement of carotenoids in the modulation of oxidative stress in vivo. We investigated further the modifications induced by an oral administration of canthaxanthin on lipid peroxidation, antioxidant enzymes and iron status in liver of Balb/c mice. Female 6-wk-old Balb/c mice were randomly divided into two groups (n ϭ 10/group). The control group (C) received olive oil alone (vehicle) and the canthaxanthin-treated group (Cx) received canthaxanthin at a dose of 14 g/(g body wt⅐d). The 15-d canthaxanthin treatment resulted in carotenoid incorporation but did not modify lipid peroxidation as measured by endogenous production of malondialdehyde (MDA). However, glutathione peroxidase activity was 35% lower (P Ͻ 0.01) and catalase (59%, P Ͻ 0.005) and manganese superoxide dismutase (MnSOD) (28%, P Ͻ 0.05) activities were higher in canthaxanthin-treated mice than in controls. Moreover, carotenoid feeding caused a significant (P Ͻ 0.05) overexpression of the MnSOD gene; mRNA levels of the enzyme were greater in treated mice than in controls. Concomitantly, a 27% (P Ͻ 0.05) greater iron concentration was found in liver from canthaxanthin-treated mice compared with controls. These findings support the hypothesis that canthaxanthin alters the protective ability of tissues against oxidative stress in vivo.

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“…they become prooxidants) or they may lose some of their antioxidant efficiency. For carotenoids, it has been reported that β-carotene (β-CAR) acts as an antioxidant at low oxygen concentration, however, under high oxygen concentration, the antioxidant activity of β-CAR is reduced [36][37][38][39][40] and in some cases it acts as prooxidant [38,41]. the peroxyl radical addition to CAR to form ROO-CAR  is smaller than that for its hydrogen abstraction from CAR [42].…”

Section: +mentioning

confidence: 99%

Peroxyl radical reactions with carotenoids in microemulsions: Influence of microemulsion composition and the nature of peroxyl radical precursor

El‐Agamey

McGarvey

2016

Free Radical Biology and Medicine

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Cite this article as: Ali El-Agamey and David J. Mcgarvey, Peroxyl radical reactions with carotenoids in microemulsions: Influence of microemulsion composition and the nature of peroxyl radical precursor, Free Radical Biology and Medicine, http://dx.doi.org/10.1016/j.freeradbiomed. 2015.10.427 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractThe reactions of acetylperoxyl radicals with different carotenoids (7,7'-dihydro-β-carotene and ζ-carotene) in SDS and CTAC microemulsions of different compositions were investigated using laser flash photolysis (LFP) coupled with kinetic absorption spectroscopy. The primary objective of this study was to explore the influence of microemulsion composition and the type of surfactant used on the yields and kinetics of various transients formed from the reaction of acetylperoxyl radicals with carotenoids. Also, the influence of the site (hydrocarbon phases or aqueous phase) of generation of the peroxyl radical precursor was examined by using 4-acetyl-4-phenylpiperidine hydrochloride

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Antioxidant and Prooxidant Role of β-Carotene in Murine Normal and Tumor Thymocytes: Effects of Oxygen Partial Pressure

Cited by 118 publications

References 33 publications

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Canthaxanthin Supplementation Alters Antioxidant Enzymes and Iron Concentration in Liver of Balb/c Mice

Peroxyl radical reactions with carotenoids in microemulsions: Influence of microemulsion composition and the nature of peroxyl radical precursor

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