Antioxidant and renoprotective activities of Ficus racemosa Linn. stem bark: Bioactivity guided fractionation study

Veerapur, Veeresh P.; Thippeswamy, B.S.; Prabhakar, K; Nagakannan, P.; Shivasharan, B. D.; Bansal, Prateek; Sneha, Sonam; Mishra, Beena; Priyadarsini, K. Indira; Unnikrishnan, M.K.

doi:10.1016/j.bionut.2011.06.002

Cited by 13 publications

(5 citation statements)

References 29 publications

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“…Hence, antioxidants are the first line of defense against free radical damage and are critical for maintaining health. Due to this, antioxidant supplements and antioxidants containing diet are now being recognized as an important means of improving free radical protection [28].…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Calendula officinalis L. Flowers Against Monosodium Glutamate Induced Oxidative Stress and Excitotoxic Brain Damage in Rats

Shivasharan¹,

Nagakannan²,

Thippeswamy³

et al. 2012

Ind J Clin Biochem

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Monosodium glutamate (MSG) is a popular flavour enhancer used in food industries; however, excess MSG is neurotoxic. Oxidative stress is well documented in MSG induced neurotoxicity. The compounds having antioxidant and anti-inflammatory properties reportedly possess beneficial effects against various neurotoxic insults. Calendula officinalis Linn. flower extract (COE) is known for its potent antioxidant and anti-inflammatory activities. Hence, this present study has been designed to evaluate the neuroprotective effect of COE on MSG-induced neurotoxicity in rats. Adult Wistar rats were administered systemically for 7 days with MSG and after one h of MSG injection, rats were treated with COE (100 and 200 mg/kg) orally. At the end the treatment period, animals were assessed for locomotor activity and were sacrificed; brains were isolated for estimation of LPO, GSH, CAT, TT, GST, Nitrite and histopathological studies. MSG caused a significant alteration in animal behavior, oxidative defense (raised levels of LPO, nitrite concentration, depletion of antioxidant levels) and hippocampal neuronal histology. Treatment with COE significantly attenuated behavioral alterations, oxidative stress, and hippocampal damage in MSG-treated animals. Hence, this study demonstrates that COE protects against MSG-induced neurotoxicity in rats. The antioxidant and anti-inflammatory properties of COE may be responsible for its observed neuroprotective action.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Calendula officinalis L. Flowers Against Monosodium Glutamate Induced Oxidative Stress and Excitotoxic Brain Damage in Rats

Shivasharan¹,

Nagakannan²,

Thippeswamy³

et al. 2012

Ind J Clin Biochem

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“…Brain was removed, homogenized in cold phosphate buffered saline (10% w/v), and the suspension was centrifuged at 12 000×g (Remi Motors Ltd., Mumbai, India) for 15 min at 4°C. The supernatant was used for the following biochemical analysis (Jadiswami et al , ; Veerapura et al, ).…”

Section: Methodsmentioning

confidence: 99%

Effect of Embelin Against Lipopolysaccharide‐induced Sickness Behaviour in Mice

Shaikh

Dhadde²,

Durg

et al. 2016

Phytotherapy Research

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Sickness behaviour is a coordinated set of adaptive behavioural changes that develop in ill individuals during the course of an infection. It is relevant to understanding depression and some aspects of the suffering that in cancer. Embelin has been reported to possess antiinflammatory, neuroprotective and anxiolytic assets and has been shown to inhibit nuclear factor κB pathway and cytokine production. The present study was undertaken to investigate the effect of embelin isolated from Embelia ribes Burm in lipopolysaccharide (LPS)-induced sickness behaviour in mice. Adult male Swiss albino mice were pre-treated with embelin (10 and 20 mg/kg, p.o.) or dexamethasone (1 mg/kg, i.p.) for 3 days and then challenged with LPS (400 µg/kg, i.p.). At different time intervals of post-LPS challenge, sickness behaviour was evaluated in the animals by battery of behavioural tests (plus maze, open field, light-dark box, forced swim, social behaviour assessment, sucrose preference and food and water intake). Levels of oxidative stress makers (reduced glutathione and lipid peroxidation) in mice brain were also analysed. LPS induced behavioural alterations, anhedonia and anorexia, in mice. Pre-treatment with embelin attenuated behavioural changes induced by LPS. In addition, embelin prevented anhedonia, anorexia and ameliorated brain oxidative stress markers. The experimental outcomes of the present study demonstrated protective effect of embelin in LPS-induced sickness behaviour in mice. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Hence, antioxidants are the first line of defense against free radical injury and are critical for keeping health. Due to this, antioxidant supplements and antioxidants enclosing diet are being recognized as an important means of improving free radical protection [30].…”

Section: Discussionmentioning

confidence: 99%

Ocimum basilicum L. (Lamiaceae) leaves aqueous extract improve learning and memory in the monosodium glutamate-induced neurotoxicity model of Alzheimer's disease through attenuating brain oxidative damage in experimental mice

Badiana

Ngah

Touo'yem

et al. 2021

GSC Biol. and Pharm. Sci.

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Ethnopharmacological relevance: Ocimum basilicum L. (Lamiaceae) is a medicinal plant known in Cameroon for the treatment of many ailments like anxiolytic, antispasmodic and mental disorders. Aim of the study: The aim of this study is to evaluate the neuroprotective effects of Ocimum basilicum. Materials and methods: T-maze test and open field test and the assay of oxidative stress parameters were used for detecting its capacity to protect neurons against excitotoxicity induced by monosodium glutamate. Results: It was found that the Ocimum basilicum significantly increased the time spent in the preferred arm of the T-maze as well as the number of entries in the same arm. The first time arm choice latency decreased significantly in the animals treated by the compared to those treated with glutamate monosodium. In the open field test, it was noted an increase in the time spent in the center and the number of lines crossed. Results shows that the of Ocimum basilicum significantly reversed the oxidative damage induced by monosodium Glutamate by reducing the levels of MDA and increasing the concentration of CAT, GSH, SOD compared to the negative glutamate monosodium and distilled water treated groups respectively [F (5, 15) = 13.51; P < 0.001]; [F (5, 15) = 12.42; P < 0.001]; [F (6, 24) = 79.74; P < 0.001] and [F (5, 15) = 18.27; P < 0.001]. Conclusion: These results suggest that Ocimum basilicum possess neuroprotectives properties in mice that might involve an action on antioxidant defense system in the central nervous system

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Antioxidant and renoprotective activities of Ficus racemosa Linn. stem bark: Bioactivity guided fractionation study

Cited by 13 publications

References 29 publications

Protective Effect of Calendula officinalis L. Flowers Against Monosodium Glutamate Induced Oxidative Stress and Excitotoxic Brain Damage in Rats

Protective Effect of Calendula officinalis L. Flowers Against Monosodium Glutamate Induced Oxidative Stress and Excitotoxic Brain Damage in Rats

Effect of Embelin Against Lipopolysaccharide‐induced Sickness Behaviour in Mice

Ocimum basilicum L. (Lamiaceae) leaves aqueous extract improve learning and memory in the monosodium glutamate-induced neurotoxicity model of Alzheimer's disease through attenuating brain oxidative damage in experimental mice

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