Antioxidant and toxicological effects elicited by alpha-lipoic acid in aquatic organisms

Kütter, Mateus Tavares; Romano, Luís Alberto; Ventura‐Lima, Juliane; Tesser, Marcelo Borges; Monserrat, José M.

doi:10.1016/j.cbpc.2014.03.008

Cited by 31 publications

(23 citation statements)

References 75 publications

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“…Its levels were similar among the control and treated groups, except a slight change in the kidney tissues of the common carp at a 7 day timescale indicated a reduced activity to protect the cells against H 2 O 2 (Figure 5). It was reported that the enhanced SOD and CAT in the hepatocytes of the fish might be prompted by microcystin [27]. …”

Section: Resultsmentioning

confidence: 99%

Tracing the Bioavailability of Three-Dimensional Graphene Foam in Biological Tissues

et al. 2017

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Graphene-based materials with a three-dimensional (3D) framework have been investigated for a variety of biomedical applications because of their 3D morphology, excellent physiochemical properties, volume stability, and their controllable degradation rate. Current knowledge on the toxicological implications and bioavailability of graphene foam (GF) has major uncertainties surrounding the fate and behavior of GF in exposed environments. Bioavailability, uptake, and partitioning could have potential effects on the behavior of GF in living organisms, which has not yet been investigated. Here, we report a pilot toxicology study on 3D GF in common carps. Our results showed that GF did not show any noticeable toxicity in common carps, and the antioxidant enzymatic activities, biochemical and blood parameters persisted within the standard series. Further histological imaging revealed that GF remained within liver and kidney macrophages for 7 days without showing obvious toxicity. An in vivo study also demonstrated a direct interaction between GF and biological systems, verifying its eco-friendly nature and high biocompatibility.

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Section: Resultsmentioning

confidence: 99%

Tracing the Bioavailability of Three-Dimensional Graphene Foam in Biological Tissues

et al. 2017

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“…The decreased MDA content in GIFT tilapia fed on L300 and L600 diets is due to higher antioxidant capacity resulting from increased enzymes activities (SOD, GSH‐Px) and non‐enzymatic antioxidants concentration (GSH). The enhanced antioxidant capacity enabled fish to cope with environmental or biological stress (Kütter et al, ). In rats, a high‐fat diet (21.45%) induced dyslipidaemia (Yang, Li, Shi, & Le, ), which supports our claim that α‐LA can decrease oxidative stress by increasing free radical scavenger enzymes.…”

Section: Discussionmentioning

confidence: 99%

Effects of α‐lipoic acid on growth performance, body composition, antioxidant profile and lipid metabolism of the GIFT tilapia (Oreochromis niloticus) fed high‐fat diets

Xiao

et al. 2019

Aquacult Nutr

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The wide use of lipid as a non‐protein energy substitute has led to lipid metabolic problems in cultured tilapia. Therefore, studies that reduce the effects of high‐fat diets in genetically improved farmed tilapia (GIFT) are required. This study evaluated the optimum level and effects of dietary α‐lipoic acid (α‐LA) on growth performance, body composition, antioxidant capacity and lipid metabolism of GIFT tilapia. The basal diet (120 g/kg lipid) was supplemented with six concentrations of α‐LA at 0 (control), L300, L600, L900, L1200 and L2400 mg/kg diet to make the experimental diets, which were fed to GIFT tilapia juveniles (initial body weight: 0.48 ± 0.01 g) for 8 weeks. The weight gain of fish improved significantly in the L300 than other dietary treatments. The intraperitoneal fat index and lipid content of fish fed on the L2400 diet decreased significantly than those fed on the control diet. The activities of superoxide dismutase and glutathione peroxidase (GSH‐Px) in serum and liver were significantly higher in fish fed on the L300 diet than the control. The reduced GSH content of fish fed on the L300 in serum and liver was significantly higher than those fed on control diet. The malondialdehyde content in serum and liver was significantly lower in L300 than in the control. The adipose triglyceride lipase gene was significantly up‐regulated in fish fed on the L2400, but the diacylglycerol acyltransferase 2 gene was down‐regulated in adipose. The liver‐type fatty acid‐binding protein gene in the liver was significantly up‐regulated in fish fed on the L300 and L600 diets. Moreover, the acyl‐coenzyme A oxidase gene in liver was significantly up‐regulated in fish fed on the L300, L600, L900 and L1200 diets. Polynomial regression analysis indicated that 439–528 mg/kg α‐LA is an appropriate dosage in high‐fat diet to improve growth performance and relieve lipid oxidative damage by accelerating lipid catabolism and reducing lipid synthesis in GIFT tilapia.

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“…Oxidative stress occurs due to the imbalance between high concentrations of pro-oxidants, which include the reactive oxygen species (ROS) and relatively low concentration of antioxidants, resulting in damage to biomolecules such as proteins, lipids and DNA (Liang et al, 2016). The ROS, produced during the aerobic metabolism process, and shrimps, like any aerobic organism, are vulnerable to the action of ROS when produced in excess surpassing the organism antioxidant defence system capacity (Kütter, Romano, Ventura-Lima, Tesser, & Monserrat, 2014). Recent studies have shown that the exposure of fish and crustaceans to ammonia is capable to increase ROS production (Liang et al, 2016;Maltez et al, 2017;Pinto et al, 2016;Zhang, Li, Wang, & Qian, 2018).…”

Section: Introductionmentioning

confidence: 99%

The role of açaí ( Euterpe oleracea Mart. 1824) as a chemoprotective agent in the evaluation of antioxidant defence, oxidative damage and histology of juvenile shrimp Litopenaeus vannamei (BOONE, 1931) exposed to ammonia

et al. 2020

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This study investigated the effects of the use of the inclusion of açaí on the diet of shrimp Litopenaeus vannamei on antioxidant and histopathological responses after exposure to ammonia. The shrimps were fed two experimental diets: control and with 10% of açaí inclusion (W/W), for 35 days. Afterwards, the organisms were exposed at four concentrations of ammonia (0.01‐control; 0.26; 0.48 and 0.91 mg NH3‐N L−1) for 96 hr. The total antioxidant capacity (ACAP) of the gills decreased significantly in both diets when exposed to ammonia, whereas in the muscle, the açaí promoted an increase in ACAP. Concomitantly, lipid peroxidation levels increased in the gills and decreased in muscle. After exposure to ammonia, glutathione‐S‐transferase activity increased in hepatopancreas in shrimps fed with açaí facilitating the detoxification of lipid peroxidation by‐products, and the concentration of protein sulfhydryl groups decreased in the gills and muscle of the shrimp of the control diet, evidencing protein damage, an unobserved response in shrimps that received the açaí diet. Histopathological changes decreased in açaí‐fed shrimps about the control diet after exposure to ammonia. It is concluded that açaí mitigated ammonia‐induced histopathological changes, improved the antioxidant defence system (gills and muscle) and attenuated the lipid damage in the muscle.

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Antioxidant and toxicological effects elicited by alpha-lipoic acid in aquatic organisms

Cited by 31 publications

References 75 publications

Tracing the Bioavailability of Three-Dimensional Graphene Foam in Biological Tissues

Tracing the Bioavailability of Three-Dimensional Graphene Foam in Biological Tissues

Effects of α‐lipoic acid on growth performance, body composition, antioxidant profile and lipid metabolism of the GIFT tilapia (Oreochromis niloticus) fed high‐fat diets

The role of açaí ( Euterpe oleracea Mart. 1824) as a chemoprotective agent in the evaluation of antioxidant defence, oxidative damage and histology of juvenile shrimp Litopenaeus vannamei (BOONE, 1931) exposed to ammonia

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