Antioxidant, anti-inflammatory and analgesic activity of Mimosa acutistipula (Mart.) Benth

Bezerra, Layza Fernanda Gomes; Silva, Ana Paula Sant'Anna da; Cunha, Rebeca Xavier da; Oliveira, João Ricardhis Saturnino de; Barros, Mateus Domingues de; Silva, Vycttor Mateus de Melo Alves da; Lima, Vera Lúcia de Menezes

doi:10.1016/j.jep.2022.115964

Cited by 3 publications

(2 citation statements)

References 94 publications

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“…Phenolics and flavonoids were also considered as the main antioxidant compounds in some plant extracts, such as A. communis [17], O. pulchra [18], E. annuus flower [19] and Mimosa acutistipula (Mart.) Benth [14].…”

Section: Discussionmentioning

confidence: 99%

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Solvent effects on terpenoid compositions and antioxidant activities of Cinnamomum camphora (L.) J. Presl extracts and the main antioxidant agent evaluation through in vitro and in vivo assay

Wang,

Zhang,

et al. 2024

Chem. Biol. Technol. Agric.

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Plant secondary metabolites can protect organisms against oxidative stress caused by adverse environmental conditions. Cinnamomum camphora (L.) J. Presl contains plentiful terpenoids and is subdivided into 5 chemotypes. To develop natural antioxidants using the plant terpenoids, the terpenoid composition and antioxidant abilities of methanol, ethyl acetate, n-hexane and petroleum ether extracts from linalool and eucalyptol chemotypes were investigated, and the solvent effects on in vitro antioxidant activity of 8 main terpenoids were analyzed. Meanwhile, the in vivo effects of two strong antioxidant terpenoids were evaluated. For the two chemotypes, the 4 solvents exhibited the same extracting effects on the terpenoid types, but methanol extracts contained the highest content of terpenoids, which should contribute to their strongest scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radicals. In linalool and eucalyptol chemotype extracts, linalool, eucalyptol, ocimene, α-pinene, D-limonene, terpinene, β-pinene and longifolene were the 8 main terpenoids. Among the 4 solvents, the 8 terpenoids showed the strongest free radical-scavenging activity with methanol as the reaction medium, which might result from strong-polarity methanol easily activating C = C unsaturated bonds in these compounds. This might also contribute to the strongest scavenging activity of methanol extracts against free radicals. Among these main components, ocimene and longifolene separately showed the strongest activity in scavenging DPPH and ABTS free radical. In in vivo assay, the two compounds significantly lowered the reactive oxygen species (ROS) levels in Chlamydomonas reinhardtii, a single-celled model organism, under H2O2 stress, and the lowering effects gradually enhanced with increasing the compound concentration, resulting in the corresponding promoting effect on the algal growth. At the same concentration, longifolene showed the strongest effect on protecting the algal cells against oxidative stress. Therefore, methanol was suitable for extracting terpenoids in natural antioxidant development, and ocimene and longifolene were two strong antioxidant terpenoids without cell toxicity, with the latter having stronger in vivo antioxidant activity. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

“…[12], Bacopa monnieri (L.) Pennell [13] and Mimosa acutistipula (Mart.) Benth [14]. Meanwhile, different solvents led to various extraction effects and antioxidant abilities, e.g., methanol (MeOH) extracts had stronger antioxidant abilities for containing more secondary metabolites in contrast to water extracts [15,16].…”

Section: Introductionmentioning

confidence: 99%

Solvent effects on terpenoid compositions and antioxidant activities of Cinnamomum camphora (L.) J. Presl extracts and the main antioxidant agent evaluation through in vitro and in vivo assay

Wang,

Zhang,

et al. 2024

Chem. Biol. Technol. Agric.

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The antioxidant, anti-inflammatory and analgesic activity effect of ethyl acetate extract from the flowers of Syringa pubescens Turcz

Zhang,

Wu,

Wang

et al. 2024

Journal of Ethnopharmacology

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Segurança E Eficácia Do Uso De Fitoterápicos Utilizados Na Prática Clínica: Uma Revisão De Literatura

Karine da Costa Duarte,

Goldfarb de Oliveira

2024

RIS

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Introdução: O uso terapêutico das plantas remonta aos tempos mais remotos da história humana, e é chamado de fitoterapia. Essa prática tem sido amplamente adotada como uma opção para tratar várias doenças. Objetivo: Identificar, através da literatura, a segurança e eficácia do uso de fitoterápicos utilizados na prática clínica. Método: Trata-se de uma revisão integrativa realizada por meio da seleção de artigos científicos publicados em periódicos indexados nas bases de dados The Scientific Electronic Library Online, Medical Literature Analysis and Retrieval Sistem On-line via PubMed e Biblioteca Virtual em Saúde, tendo a busca ocorrida entre os meses de janeiro a abril de 2024. O levantamento bibliográfico fez referência às publicações de artigos científicos entre os anos de 2020 a 2024, que estivessem disponíveis na íntegra, na língua portuguesa e inglesa, estudos transversais, de intervenção, prospectivo de caso controle e relato de caso. Foram excluídos resumos de apresentações, monografias, revisões, dissertações e/ou teses acadêmicas. Após análise e seleção, doze estudos compuseram a amostra. Resultados: Podemos identificar que as plantas medicinais são eficazes em tratamentos de diversas patologias e condições, como distúrbios do sono decorrentes da menopausa, infecções urinárias, malária, câncer, hiperglicemia, hipertrigliceridemia, feridas cutâneas, doença pulmonar obstrutiva crônica, depressão, e úlceras gastrointestinais. Além de possuírem atividade antioxidante, anti-inflamatória, analgésica e antipirética Conclusão: Do tratamento de distúrbios gastrointestinais à melhoria da saúde mental, as plantas medicinais oferecem uma fonte valiosa de compostos bioativos que podem complementar ou até mesmo substituir terapias convencionais. As plantas medicinais têm o potencial de desempenhar um papel vital na promoção da saúde e no tratamento de doenças, oferecendo uma abordagem holística e natural para o cuidado do corpo e da mente. Palavras-chave: Plantas Medicinais; Fitoterapia; Eficácia.

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Antioxidant, anti-inflammatory and analgesic activity of Mimosa acutistipula (Mart.) Benth

Cited by 3 publications

References 94 publications

Solvent effects on terpenoid compositions and antioxidant activities of Cinnamomum camphora (L.) J. Presl extracts and the main antioxidant agent evaluation through in vitro and in vivo assay

Solvent effects on terpenoid compositions and antioxidant activities of Cinnamomum camphora (L.) J. Presl extracts and the main antioxidant agent evaluation through in vitro and in vivo assay

The antioxidant, anti-inflammatory and analgesic activity effect of ethyl acetate extract from the flowers of Syringa pubescens Turcz

Segurança E Eficácia Do Uso De Fitoterápicos Utilizados Na Prática Clínica: Uma Revisão De Literatura

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