Antioxidant, Anti‐Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction

Abstract

In this study, a chemical investigation on the fruits of Livistona chinensis (FLC) led to the isolation and identification of 45 polyphenols and 5 alkaloids, including two new compounds (Livischinol (1) and Livischinine A (46)), an undescribed compound (47) and 47 known compounds. FLC was predicted with novel potential antidiabetic function by collecting and analyzing the potential targets of the ingredients. Compound 32 exhibited significant α-glucosidase inhibitory activity ( I C 50 = 5.71 μM) and 1, 6, and 44 showed the PTP1B inhibitory activity with IC50 values of 9.41-22.19 μM, while that of oleanolic acid was 28.58 μM. The competitive inhibitors of PTP1B (compounds 1 and 44) formed strong binding affinity, with catalytic active sites, proved by kinetic analysis, fluorescence spectra measurements, and computational simulations, and stimulated glucose uptake in the insulin-resistant HepG2 cells at the dose of 50 μM. In addition, FLC was rich in antioxidant and anti-inflammatory bioactive compounds so that they could be developed as nutraceuticals against diabetes.

Luteolin-Rich Extract of Thespesia garckeana F. Hoffm. (Snot Apple) Contains Potential Drug-Like Candidates and Modulates Glycemic and Oxidoinflammatory Aberrations in Experimental Animals

“…The prevalence of diabetes is very high, affecting millions of people globally [ 3 ]. It is characterized by the development of insulin resistance, abnormal insulin signaling, oxidative stress [ 4 ], inflammation [ 5 ], and organ dysfunction [ 6 ], leading to decreased life quality and high mortality [ 7 ]. In the past few decades, DM, particularly type 2 DM (T2DM), has become a global health problem that threatens millions of people in both developed and developing countries [ 2 ].…”

Metabolic profiling and biological activity of twoLivistonaspecies:L. chinensisandL. australis

“…Previous reports on the antidiabetic potential of L. chinensis was evaluated by measuring the α-glucosidase inhibitory effect and protein tyrosine phosphatase 1B (PTP1B) inhibitory effect, and the results showed that the butyl alcohol fraction was the most potent as an α-glucosidase and PTP1B inhibitor. 21 The activity of the leaf extract may be attributed to the flavonoid content of the extract. Many flavonoids reported as DPP-IV inhibitors, such as quercetin, luteolin, apigenin, kaempferol, flavone, hesperetin, naringenin and genistin, in addition to glycosides as isoquercetin, kaempferol 7- O -α- l -rhamnoside, vitexin, rutin, isorhamnetin-3- O -glucoside and isorhamnetin-3- O -rutinoside, have also been reported as DPP-IV inhibitors.…”

“… 20 The fruits of L. chinensis are edible in eastern Asia, they are a component of prepared soups used in the treatment of liver cancer and chronic hepatitis. 21 The nutritional evaluation of the leaves and fruits of L. australis also showed that the fruits are a good source of calcium and potassium. 22 This work aims to identify the secondary metabolites in the leaves and fruits of L. chinensis and L. australis using UPLC coupled with high-resolution electron spray ionization mass (HRESIMS), and evaluate their anticholinesterase, DPP-IV inhibitory potential, and telomerase activation potential.…”

Flavonoids as dual-target inhibitors against α-glucosidase and α-amylase: a systematic review of in vitro studies

“…99,[158][159][160] Once again, these gathered results facilitate future efforts in investigating these interesting scaffolds. The next ten compounds (52)(53)(54)(55)(56)(57)(58)(59)(60)(61) of this subclass feature flavone glycosides, most commonly glycosylated at the R7 oxygen. Of these glycosides, luteolin-7-O-β-D-glucoside ( 56) is the most well-researched with five studies, 57,114,123,161,162 outlining a comparable activity to acarbose on α-glucosidase and a weaker inhibition on α-amylase.…”