Antioxidant, anti-inflammatory and antimicrobial activities promoted by hydroalcoholic extract of Laguncularia racemosa (l) c.f. leaves Gaert

Abstract

This study aimed to evaluate the antioxidant, anti-inflammatory, antimicrobial and toxicity potential of the hydroalcoholic extract of the leaves of L. racemosa (EHALr) a mangrove plant. The results showed that the extract was able to promote moderate antioxidant activity. In acute toxicity assays, EHA-Lr showed low toxicity, with no significant changes in animal and organ weights and in biochemical and hematological parameters. In the evaluation of anti-inflammatory activity, the 200 mg/kg dose of EHA-Lr was most effective in reducing leukocyte migration in the paw edema model and in the LPS-induced acute lung inflammation model the 50 mg/kg dose was most effective in reducing plantar volume. The antimicrobial potential of the hydroalcoholic extract was observed against Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Pseudomonas aeruginosa, Serratia marcencens, Escherichia coli and Enterococcus faecalis strains, proving to be effective. However, the extract was most active against the Micrococcus luteus strain (0.93mg/mL). The hydroalcoholic extract of L. racemosa leaves showed anti-inflammatory and antimicrobial activities, with low toxicity, which makes it a strong promise to be applied or combined in clinical therapy.