Antioxidant, anti-inflammatory and neuroprotective activities of plastoquinones from the seed fat of Pycnanthus Angolensis

Gustafson, KR; Giurleo, Daniel; Ho, CT; Dang, Wenxi; Pan, MH; Wu, Qin; Simon, JE

doi:10.1055/s-0032-1320385

Cited by 3 publications

(2 citation statements)

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“…It must be noted, that the closer an IC 50 value of an extract is to zero, the more likely it is for the extract to possess potent antioxidant capabilities (24). Thus, the crude sap of P. angolensis was a more powerful antioxidant than the ethanol extract of C. sanguinolenta, which was also a better antioxidant than the aqueous extract of C. sanguinolenta.…”

Section: Phytoconstituents Screenedmentioning

confidence: 99%

“…The total phenolic content of the extracts was assessed using a modi ed Gustafson et al (2012) (24) technique and the Folin-Ciocalteu reagent. A concentration of 5 mg/mL of pyro-gallic acid solution (which was prepared by diluting 5 mg of pyro-gallic acid powder with 100 µL of absolute ethanol and 900 µL of distilled water), which was diluted to 10 different concentrations using a two-fold dilution served as the reference standard for the analysis.…”

Section: Determination Of Total Phenol Contentmentioning

confidence: 99%

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Antimicrobial activities and total phenolic contents of the sap of Pycnanthus angolensis and root of Cryptolepis sanguinolenta

Adu-Amankwaah

Sam

Asare

et al. 2023

Preprint

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The death of many people in tropical countries can be attributed to microbial infection, probably, because synthetic antibiotics are failing in the treatment of these microbial infections, attributed to the ability of the microorganisms to mutate and adapt to harsh conditions. This study evaluated, in vitro, the antimicrobial activities, antioxidant potentials, and the total phenolic contents of aqueous and ethanol extracts of the root of Cryptolepis sanguinolenta (Lindl.) and the crude sap of Pycnanthus angolensis (Welw) using selected standard bacteria strains (S. aureus (ATCC 25923), S. saprophyticus (ATCC 15305), E. coli (ATCC 25922), S. typhi (ATCC 19430), P. aeruginosa (ATCC 27853), and P. mirabilis (ATCC 49565). The modified agar well diffusion method was used to evaluate the antimicrobial activities of the plant extracts. Chloramphenicol and tetracycline were used as positive controls. The extracts were also screened for specific phytochemicals and using the Folin Ciocalteu reagent test, their total phenolic contents were determined. The phytochemical screening revealed the presence of alkaloids, cardiac glycosides, and saponins in both Cryptolepis sanguinolenta and Pycnanthus angolensis. For the antimicrobial activities, all the test bacteria were susceptible to the crude sap of Pycnanthus angolensis except P. mirabilis. In the case of the Cryptolepis sanguinolenta, only S. aureus was susceptible to both aqueous and ethanol extracts. The total phenolic content, expressed in g/100g GAE, recorded values of 55.427 ± 4.248 for the crude sap of Pycnanthus angolensis, and 11.642 ± 4.248 and 26.888 ± 4.248 for the aqueous and ethanol extracts of Cryptolepis sanguinolenta, respectively. It was concluded that Cryptolepis sanguinolenta and Pycnanthus angolensis are excellent candidates for further development of antimicrobial agents in the fight against microbial infections given the pressing need for novel efficacious agents.

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Section: Phytoconstituents Screenedmentioning

confidence: 99%

Section: Determination Of Total Phenol Contentmentioning

confidence: 99%

Antimicrobial activities and total phenolic contents of the sap of Pycnanthus angolensis and root of Cryptolepis sanguinolenta

Adu-Amankwaah

Sam

Asare

et al. 2023

Preprint

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Phytochemical and pharmacological review of Erica Genus (L.) Ericaceae plants

Adu-Amankwaah,

Mpundu,

Nyambo

et al. 2025

Phytomedicine Plus

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Antimicrobial, antioxidant activities, and total phenolic contents of Pycnanthus angolensis Sap and Cryptolepis sanguinolenta root extracts

Adu-Amankwaah

Sam

Asare

et al. 2023

BMC Complement Med Ther

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The death of many people in tropical countries can be attributed to microbial infection, probably, because synthetic antibiotics are failing in the treatment of most microbial infections, attributed to the ability of the microorganisms to mutate and adapt to harsh conditions. This study evaluated, in vitro, the antimicrobial activities, antioxidant potentials, and the total phenolic as well as phytochemical contents of aqueous and ethanol extracts of the root of Cryptolepis sanguinolenta (Lindl.) and the crude sap of Pycnanthus angolensis (Welw) using selected standard bacteria strains (Staphylococcus aureus (ATCC 25,923), Staphylococcus saprophyticus (ATCC 15,305), Escherichia coli (ATCC 25,922), Salmonella typhi (ATCC 19,430), Pseudomonas aeruginosa (ATCC 27,853), and Proteus mirabilis (ATCC 49,565). The modified agar well diffusion method was used to evaluate the antimicrobial activities of the plant extracts. Chloramphenicol and tetracycline were used as positive controls. The extracts were screened for specific phytochemicals with total phenolic contents were determined using Folin Ciocalteu reagent test. The phytoconstituents observed were alkaloids, cardiac glycosides, and saponins in both Cryptolepis sanguinolenta and Pycnanthus angolensis. For the antimicrobial activities, all the test bacteria were susceptible to the crude sap of Pycnanthus angolensis except Proteus mirabilis. In the case of the Cryptolepis sanguinolenta, only S. aureus was susceptible to both aqueous and ethanol extracts. The total phenolic content, expressed in g/100 g GAE, recorded values of 55.427 ± 4.248 for the crude sap of Pycnanthus angolensis, and 11.642 ± 4.248 and 26.888 ± 4.248 for the aqueous and ethanol extracts of Cryptolepis sanguinolenta, respectively. It is concluded that Cryptolepis sanguinolenta and Pycnanthus angolensis are excellent candidates for further development of antimicrobial agents in the fight against microbial infections given the pressing need for novel efficacious agents.

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Antioxidant, anti-inflammatory and neuroprotective activities of plastoquinones from the seed fat of Pycnanthus Angolensis

Cited by 3 publications

References 0 publications

Antimicrobial activities and total phenolic contents of the sap of Pycnanthus angolensis and root of Cryptolepis sanguinolenta

Antimicrobial activities and total phenolic contents of the sap of Pycnanthus angolensis and root of Cryptolepis sanguinolenta

Phytochemical and pharmacological review of Erica Genus (L.) Ericaceae plants

Antimicrobial, antioxidant activities, and total phenolic contents of Pycnanthus angolensis Sap and Cryptolepis sanguinolenta root extracts

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