Antioxidant, anti-inflammatory, and wound healing effects of topical silver-doped zinc oxide and silver oxide nanocomposites

Moura, Francyelle Borges Rosa de; Ferreira, Bruno Antônio; Muniz, Elusca Helena; Justino, Allisson Benatti; Silva, Ana Gabriela; Ribeiro, Rosy Iara Maciel de Azambuja; Dantas, Noélio O.; Ribeiro, Daniele Lisboa; Araujo, Fausto G.; Espíndola, Foued Salmen; Silva, Anielle Christine Almeida; Tomiosso, Tatiana Carla

doi:10.1016/j.ijpharm.2022.121620

Cited by 16 publications

(13 citation statements)

References 65 publications

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“…Biomedical applications also include cancer therapy, wound treatment, tissue protection from oxidative stress, therapy of stomach ulcer, etc. [29][30][31]. An important application at the interface of biomedicine and ecology is the use of Ag 2 O NPs for photocatalytic destruction of pharmaceutical micro-pollutants [32].…”

Section: Introductionmentioning

confidence: 99%

Ag2O Nanoparticles as a Candidate for Antimicrobial Compounds of the New Generation

et al. 2022

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Antibiotic resistance in microorganisms is an important problem of modern medicine which can be solved by searching for antimicrobial preparations of the new generation. Nanoparticles (NPs) of metals and their oxides are the most promising candidates for the role of such preparations. In the last few years, the number of studies devoted to the antimicrobial properties of silver oxide NPs have been actively growing. Although the total number of such studies is still not very high, it is quickly increasing. Advantages of silver oxide NPs are the relative easiness of production, low cost, high antibacterial and antifungal activities and low cytotoxicity to eukaryotic cells. This review intends to provide readers with the latest information about the antimicrobial properties of silver oxide NPs: sensitive organisms, mechanisms of action on microorganisms and further prospects for improving the antimicrobial properties.

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Section: Introductionmentioning

confidence: 99%

Ag2O Nanoparticles as a Candidate for Antimicrobial Compounds of the New Generation

et al. 2022

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“…Additionally, cells were treated with AgONPs at doses ranging from 100 to 5 µg /mL. To demonstrate the biocompatibility of AgONPs, an MTT cell viability experiment 56 was carried out. The cell lines reacted to AgONPs in a concentration-dependent manner.…”

Section: Resultsmentioning

confidence: 99%

Biogenic synthesis, characterization, and in vitro biological investigation of silver oxide nanoparticles (AgONPs) using Rhynchosia capitata

Ullah,

Iqbal,

Gul

et al. 2024

Sci Rep

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The current research aimed to study the green synthesis of silver oxide nanoparticles (AgONPs) using Rhynchosia capitata (RC) aqueous extract as a potent reducing and stabilizing agent. The obtained RC-AgONPs were characterized using UV, FT-IR, XRD, DLS, SEM, and EDX to investigate the morphology, size, and elemental composition. The size of the RC-AgONPs was found to be ~ 21.66 nm and an almost uniform distribution was executed by XRD analysis. In vitro studies were performed to reveal biological potential. The AgONPs exhibited efficient DPPH free radical scavenging potential (71.3%), reducing power (63.8 ± 1.77%), and total antioxidant capacity (88.5 ± 4.8%) to estimate their antioxidative power. Antibacterial and antifungal potentials were evaluated using the disc diffusion method against various bacterial and fungal strains, and the zones of inhibition (ZOI) were determined. A brine shrimp cytotoxicity assay was conducted to measure the cytotoxicity potential (LC50: 2.26 μg/mL). In addition, biocompatibility tests were performed to evaluate the biocompatible nature of RC-AgONPs using red blood cells, HEK, and VERO cell lines (< 200 μg/mL). An alpha-amylase inhibition assay was carried out with 67.6% inhibition. Moreover, In vitro, anticancer activity was performed against Hep-2 liver cancer cell lines, and an LC50 value of 45.94 μg/mL was achieved. Overall, the present study has demonstrated that the utilization of R. capitata extract for the biosynthesis of AgONPs offers a cost-effective, eco-friendly, and forthright alternative to traditional approaches for silver nanoparticle synthesis. The RC-AgONPs obtained exhibited significant bioactive properties, positioning them as promising candidates for diverse applications in the spheres of medicine and beyond.

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“…Moura et al 186 demonstrated that the 1D/3D Ag-ZnO nanocomposite with NR/nanoplatelet morphologies could heal the wounds (in the dorsal region of BALB/c mice) with This journal is © The Royal Society of Chemistry 2024 non-cytotoxicity, especially on keratinocytes and collagen deposition, and increase metalloproteinase activities. It was explained that the Ag-ZnO based healing material healed the wound by reducing the inflammatory process, protecting tissues from damage caused by free radicals, and increasing collagen deposition in the extracellular matrix.…”

Section: Applications In Wound Healing Activitymentioning

confidence: 99%

ZnO based 0–3D diverse nano-architectures, films and coatings for biomedical applications

Krishna,

Jakmunee,

Mishra

et al. 2024

J. Mater. Chem. B

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Antioxidant, anti-inflammatory, and wound healing effects of topical silver-doped zinc oxide and silver oxide nanocomposites

Cited by 16 publications

References 65 publications

Ag2O Nanoparticles as a Candidate for Antimicrobial Compounds of the New Generation

Ag2O Nanoparticles as a Candidate for Antimicrobial Compounds of the New Generation

Biogenic synthesis, characterization, and in vitro biological investigation of silver oxide nanoparticles (AgONPs) using Rhynchosia capitata

ZnO based 0–3D diverse nano-architectures, films and coatings for biomedical applications

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