ANTIOXIDANT, ANTIBACTERIAL POTENTIAL AND HPLC ANALYSIS OF Dioscorea alata BULB

Anisuzzman, Md.; Zilani, Md. Nazmul Hasan; Khushi, Sharmin Sultana; Asaduzzman, Md.; Hossain, Md. Golam

doi:10.14499/indonesianjpharm27iss1pp9

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…The extract of D. alata bulb exhibited antibacterial activity based on significant zone of inhibition against all experimental bacterial strains used except for Staphylococcus epidermidis. However, further study is needed to confirm the contribution of myricetin and other phenolic compound actions on this antibacterial activity (Anisuzzman et al, 2016).…”

Section: Antimicrobial Activitymentioning

confidence: 96%

“…Methyl-3,4-dihydroxybenzoate, one of the phenolic compounds isolated for the first time from D. alata tuber has higher antioxidant activity (IC50: 9,41 ppm) than the positive control ascorbic acid and the other compounds found in plant, 9,10-dihydrophenanthrene-2,4,7-triol (Aminah et al, 2017). Myricetin, a flavonoid was proposed to contribute to the antioxidant and reducing power activity possessed by D. alata bulb (Anisuzzman et al, 2016). The extract showed stronger antioxidant properties (IC50=14.68 µg/mL) than to the standard antioxidant ascorbic acid (IC50=24.95 µg/mL) in DPPH assay and comparable reducing power with maximum absorption of 1.317 compared to standard BHT of 1.472 at 1 mg/mL.…”

Section: B Pharmacological Activities 1 Antioxidant Activitymentioning

confidence: 99%

“…This species is also virtually unknown in the wild ASM Science Journal, Volume 18, 2023 2 except for occasional records. In Southeast Asia where it was first cultivated, it serves as a source of carbohydrate (Anisuzzman et al, 2016;Jumari et al, 2019). It usually appears as a single tuber varying in size and shape and has succulent caudiciform with an underground tuberous root.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological Activities of Dioscorea spp.: A Narrative Review

Jamaludin,

Md Saad,

Md Jamil

et al. 2023

ASMScJ

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Pharmacological research has become essential for the development of nature-based drugs to support the claimed therapeutic properties of medicinal plants. Dioscorea species are medicinal plants found to have an impressive pharmacological profile. This review aims to compile the pharmacological properties of three Dioscorea species, D. hispida, D. alata and D. bulbifera and their derived compounds through scientific findings, mainly focusing on the biological activities. Relevant clinical and preclinical studies on the pharmacological properties of these plants were identified, screened, and analysed. A systematic search using predetermined keywords on electronic databases (Scopus, Springer and ScienceDirect) was conducted. This review found these Dioscorea species to possess various pharmacological activities such as anti-inflammatory, antimicrobial, anticancer, antioxidant, anti-diabetic, antihypertensive and estrogenic effects. The plant tubers contain active compounds such as diosgenin that is responsible for anti-inflammatory and anti-diabetic activities in D. alata and D. bulbifera, respectively. Other compounds like dioscorine, phenolic, flavonoid and terpenoid elucidated from the yam tubers were found to be antimicrobial and showed prominent free radical scavenging effects. The plants demonstrated various pharmacological activities although data on their mechanisms of action is very limited. Therefore, further research is needed to explore the full potential of these plants as future therapeutic medicines.

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Section: Antimicrobial Activitymentioning

confidence: 96%

Section: B Pharmacological Activities 1 Antioxidant Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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