Antioxidant, antidiabetic and anticancer studies of nickel complex of Vanillin-4-Methyl-4-Phenyl-3-Thiosemicarbazone

Weakly antiferromagnetic vanillin and acetate bridged dinuclear Ni(ii) compound exhibiting catecholase-like activity and biological properties

“…However, an IC50 value of 54.3 AE 1.7 mg mL À1 was observed against HeLa cervical cell lines by a complex of nickel with Schiff base vanillin-4-methyl-4-phenyl-3-thiosemicarbazone. 91 In contrast, IC50 of 4.3 mM and 10 mM were observed for an azido-bridged dinuclear copper(II) thiosemicarbazide complex against AGS and A549 cancer cells, respectively. 90 Although compound 1 has a high IC50 value, it is apparent that the complex can inhibit the proliferation of HepG2 cells in a dosedependent manner, indicating that this complex can be used as an effective agent for antitumor activity.…”

“…Similar morphological alterations in the HeLa cervical cell line (spherical and granular changes in shape) have been reported recently in the presence of nickel with the Schiff base vanillin-4-methyl-4-phenyl-3thiosemicarbazone complex. 91 It was observed that cis-platin showed an IC50 value of 2.23 AE 0.02 mg mL À1 (2.95 mM mL À1 ) which is eleven times more effective than 1, i.e. 22.82 AE 0.09 mg mL À1 (30.26 mM mL À1 ), on HepG2 cancerous cells.…”

CT-DNA/BSA Binding Studies of Thiosemicarbazone-Derivated Zn(II) Complex

“…The diffraction peak at 2Ɵ=24.06 may have been caused by the bond of Zn-S (33,34). Observing the sharp crystalline peaks arise the crystalline behavior of the samples (35).…”

A Review: Depolymerization of Lignin to Generate High-Value Bio-Products: Opportunities, Challenges, and Prospects

“…Most of these studies indicate that vanillin is a pharmacological candidate to alleviate mutagenicity-associated diseases, especially cancers. The development of vanillin derivatives coupled with metals (e.g., Ni and Co.) as cancer therapeutics is one of the growing research interests (Kumar et al, 2017a;Kumar et al, 2021;Bahron et al, 2019).…”