Potentilla discolor Bunge is commonly found in the North Temperate Zone and has a long history of clinical application in Chinese medicine. Potentilla discolor Bunge could effectively treat diarrhea, malaria, hemoptysis, hematemesis, ringworm, and many other diseases (Zhang et al., 2010). Recently, it was found that the whole herb of Potentilla discolor Bunge has antioxidant and anti-inflammatory activities, besides it can lower blood glucose and protect pancreatic β-cells against type 2 diabetes (Tomczyk & Latte, 2009). The main bioactive compounds in Potentilla discolor Bunge include flavonoids, triterpenoids, alkaloids, polysaccharides, oil, etc., especially polysaccharide active compounds (Cheng et al., 2020;Wang et al., 2019;Zhang et al., 2018). However, the mechanism of its bioactivities has not been fully understood so far. Thus, it is of great importance to reveal the bioactive ingredients in Potentilla discolor Bunge.Polysaccharides are macromolecular compounds extracted from plants, animals, and microorganisms, which are formed by polymerization of multiple monosaccharides or their derivatives (Xie et al., 2016). Recently, the excellent bioactivities of plant polysaccharides have attracted increasing attention, such as antioxidant activity, hypoglycemic activity (Chen et al., 2018), hepatoprotective