Antioxidant, antifungal, water binding, and mechanical properties of poly(vinyl alcohol) film incorporated with essential oil as a potential wound dressing material

Kavoosi, Gholamreza; Nateghpoor, Behroz; Dadfar, Seyed Mohammad Mahdi; Dadfar, Seyed Mohammad Ali

doi:10.1002/app.40937

Cited by 43 publications

(31 citation statements)

References 48 publications

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“…Table reports the antioxidant activities of the PVA, gelatin, and PVA–gelatin dispersions incorporated with 10% w/w ZO against ABTS and DPPH radicals. The pure gelatin dispersion had a slight antioxidant activity, whereas the pure PVA did not have any inherent antioxidant activity . PVA, gelatin, and their blends, which were mixed with ZO, had potent antioxidant activities.…”

Section: Resultsmentioning

confidence: 96%

Preparation and characterization of a novel gelatin–poly(vinyl alcohol) hydrogel film loaded with Zataria multiflora essential oil for antibacterial–antioxidant wound‐dressing applications

Kavoosi

Bordbar

Dadfar

et al. 2017

J of Applied Polymer Sci

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This study was performed to evaluate the properties of poly(vinyl alcohol) (PVA), gelatin, and PVA-gelatin dispersions and films enriched with Zataria multiflora essential oil (ZO). The results reveal that the f potential, particle size, and viscosity values and the antioxidant and antibacterial activities of the dispersions changed significantly with the addition of ZO to the polymer matrix. Changes in the properties of the dispersions suggested the presence of interactions between PVA or gelatin and ZO. Such interactions could affect the mechanical and water-barrier properties of the films. ZO induced remarkable decreases in the tensile strength, elastic modulus, and swelling and increases in the elongation at break, solubility, and water-vapor permeability of the films. Scanning electron microscopy analyses proved the impact of ZO on the film morphology, which affected the film properties, including the mechanical and water-barrier properties. The addition of ZO to the polymer led to a coarse film microstructure because of the hydrophobic ZO aggregates, which produced discontinuities in the film matrix. ZO considerably increased the antioxidant and antibacterial activities of the dispersions. Pseudomonas aeruginosa was the most resistant bacteria. The improved antioxidant and antimicrobial activities of the PVA-ZO and gelatin-ZO indicated that such products could effectively be used as wound dressings.

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Section: Resultsmentioning

confidence: 96%

Preparation and characterization of a novel gelatin–poly(vinyl alcohol) hydrogel film loaded with Zataria multiflora essential oil for antibacterial–antioxidant wound‐dressing applications

Kavoosi

Bordbar

Dadfar

et al. 2017

J of Applied Polymer Sci

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“…Kavossi et al [200] prepared PVA films incorporated with Zataria multiflora essential oil by casting. The resulting films showed antifungal activity against Paecilomyces variotii , Trichoderma harizanum , Aspergillus oryzae , and Aspergillus niger .…”

Section: Combination Of Nanostructured Dressings With Essential Oilsmentioning

confidence: 99%

Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

et al. 2015

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A fast and effective wound healing process would substantially decrease medical costs, wound care supplies, and hospitalization significantly improving the patients’ quality of life. The search for effective therapeutic approaches seems to be imperative in order to avoid the aggravation of chronic wounds. In spite of all the efforts that have been made during the recent years towards the development of artificial wound dressings, none of the currently available options combine all the requirements necessary for quick and optimal cutaneous regeneration. Therefore, technological advances in the area of temporary and permanent smart dressings for wound care are required. The development of nanoscience and nanotechnology can improve the materials and designs used in topical wound care in order to efficiently release antimicrobial, anti-inflammatory and regenerative compounds speeding up the endogenous healing process. Nanostructured dressings can overcome the limitations of the current coverings and, separately, natural origin components can also overcome the drawbacks of current antibiotics and antiseptics (mainly cytotoxicity, antibiotic resistance, and allergies). The combination of natural origin components with demonstrated antibiotic, regenerative, or anti-inflammatory properties together with nanostructured materials is a promising approach to fulfil all the requirements needed for the next generation of bioactive wound dressings. Microbially compromised wounds have been treated with different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring antimicrobial, anti-inflammatory, and regenerative components but the available evidence is limited and insufficient to be able to draw reliable conclusions and to extrapolate those findings to the clinical practice. The evidence and some promising preliminary results indicate that future comparative studies are justified but instead of talking about the beneficial or inert effects of those natural origin occurring materials, the scientific community leads towards the identification of the main active components involved and their mechanism of action during the corresponding healing, antimicrobial, or regenerative processes and in carrying out systematic and comparative controlled tests. Once those natural origin components have been identified and their efficacy validated through solid clinical trials, their combination within nanostructured dressings can open up new avenues in the fabrication of bioactive dressings with outstanding characteristics for wound care. The motivation of this work is to analyze the state of the art in the use of different essential oils, honey, cationic peptides, aloe vera, plant extracts, and other natural origin occurring materials as antimicrobial, anti-inflammatory and regenerative components with the aim of clarifying their potential clinical use in bioactive dressings. We conclude that, for those natural occurring materials, more clinical trials are needed to reach a sufficient level ...

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“…Besides its content in carbohydrates (31 % glucose and 38 % fructose) honey includes components from the plants and some from the bees. Its pronounced antimicrobial effect is due to its acidity (pH 3.2-4.5), to its high sugar content (draws water from bacterial cells through osmosis), to some phenols, methylglyoxal and peptides it contains, and even to the hydrogen peroxide resulting when the glucose oxidase introduced by the bees catalyzes the oxidation of glucose [ 28 ]. Honey compositions vary depending on the fl oral source.…”

Section: Carbohydrates and Polysaccharides From Honey And Seaweed Inmentioning

confidence: 99%

Bionanomaterials from Plant Sources

Leonida

Kumar

2016

SpringerBriefs in Bioengineering

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At the present an unprecedented interest in herbal healing is appearing everywhere. The Western world started to compare allopathic remedies (with many side effects) to the traditional ones and to acknowledge the latter as safer alternatives. In spite of their advantages, applications are slow to materialize, with poor solubility and low bioavailability being the main reasons. Natural products such as curcumin, hop extracts, essential oils are example of species with demonstrated biological activity but few applications due to unsatisfactory bioavailability correlated with low water solubility. Natural products with strong antioxidant effect, like polyphenols in teas, for example, are not widely used because of their sensitivity to oxidation (during processing and storage).Nanotechnology offers a huge promise for these compounds. The disadvantages mentioned disappear upon encapsulating them in nanosized carriers with appropriate chemistry. An added bonus thereof is the possibility of controlled delivery. Phenolic Compounds from Plant Sources Delivered as NanoparticlesPolyphenols are chemical structures in which there is at least one aromatic ring with a reactive hydroxyl group and they are classifi ed according to the number and the structural elements linking these rings. They can be found in several plants (mostly in leaves and fruits) and came to public attention when their capacity to fi ght reactive oxygen species (ROS) was discovered. Phenolics (including fl avonoids, anthocyanins, lignins) are secondary metabolites in plants and are important for disease resistance, tolerance to abiotic stress, and for fi ghting bacteria. Tolerance of bacteria for polyphenols depends on the type of bacterium and the structure of the polyphenol.

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Antioxidant, antifungal, water binding, and mechanical properties of poly(vinyl alcohol) film incorporated with essential oil as a potential wound dressing material

Cited by 43 publications

References 48 publications

Preparation and characterization of a novel gelatin–poly(vinyl alcohol) hydrogel film loaded with Zataria multiflora essential oil for antibacterial–antioxidant wound‐dressing applications

Preparation and characterization of a novel gelatin–poly(vinyl alcohol) hydrogel film loaded with Zataria multiflora essential oil for antibacterial–antioxidant wound‐dressing applications

Smart Dressings Based on Nanostructured Fibers Containing Natural Origin Antimicrobial, Anti-Inflammatory, and Regenerative Compounds

Bionanomaterials from Plant Sources

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